Science Inventory

Dose-Response Modeling for Determining Transcriptomic Reference Values

Citation:

Everett, L. Dose-Response Modeling for Determining Transcriptomic Reference Values. OpenTox Summer School, Virtual, NC, July 24 - 31, 2023. https://doi.org/10.23645/epacomptox.23786334

Impact/Purpose:

Presentation to OpenTox Summer School July 2023

Description:

There is increasing interest in the application of dose-response modeling approaches to broad/non-targeted profiling data, such as transcriptomics, in order to derive mechanism-agnostic reference values for potentially hazardous chemicals. In this session, I will present an overview of existing approaches to dose-response modeling of transcriptomic and other high-dimensional data sources as well as possible regulatory use cases, including the recently proposed EPA Transcriptomics Assessment Product (ETAP, see https://www.epa.gov/bosc/epa-transcriptomic-assessment-products-etap-panel). A demonstration will then be presented with the widely used open-source platform BMDExpress. For those interested in getting a jump start, BMDExpress v2.3 can be downloaded here: https://github.com/auerbachs/BMDExpress-2/releases. This abstract does not necessarily reflect US EPA policy. Company or product names do not constitute endorsement by US EPA.