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SeqAPASS Version 6.0 – Integrating Ecotoxicology Data into sequence-based predictions of chemical susceptibility
Citation:
LaLone, C. SeqAPASS Version 6.0 – Integrating Ecotoxicology Data into sequence-based predictions of chemical susceptibility. CompTox Communities of Practice Webinar, RTP, NC, October 28, 2021. https://doi.org/10.23645/epacomptox.17113868
Impact/Purpose:
Presentation to the CompTox Communities of Practice Webinar October 2021. The US Environmental Protection Agency Sequence Alignment to Predict Across Species Susceptibility tool (SeqAPASS; https://seqapass.epa.gov/seqapass/) was developed to comparatively evaluate protein sequence and structural similarity across species as a means to extrapolate toxicity data/knowledge. SeqAPASS output provides a prediction of chemical susceptibility based on principles of evolutionary biology in understanding species relatedness at the molecular level. New to SeqAPASS Version 6 include the following: • A widget has been developed to rapidly connect SeqAPASS sequence-based predictions of chemical susceptibility to existing curated empirical toxicity data for terrestrial and aquatic species. The ECOTOXicology Knowledgebase (https://cfpub.epa.gov/ecotox/) is a publicly available resource for single chemical environmental toxicity data on aquatic life, terrestrial plants and wildlife. Therefore, an ECOTOX Widget is now available within SeqAPASS for users to readily select species from SeqAPASS output on the Level 1 results page and chemical(s) of interest to pass to the ECOTOX Knowledgebase Explore feature and identify relevant toxicity data.
Description:
Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS), is a fast, online screening tool that allows researchers and regulators to extrapolate toxicity information across species. For some species, such as humans, mice, rats, and zebrafish, the EPA has a large amount of data regarding their toxicological susceptibility to various chemicals. However, the toxicity data for numerous other plants and animals is very limited. SeqAPASS extrapolates from these data rich model organisms to thousands of other non-target species to evaluate their specific potential chemical susceptibility. Version 6.0 adds interoperability with the ECOTOXicology Knowledgebase, a comprehensive, publicly available Knowledgebase providing single chemical environmental toxicity data on aquatic life, terrestrial plants and wildlife. This update allows users to connect computational predictions of chemical susceptibility to the wealth of knowledge available in ECOTOX. This abstract does not necessarily reflect U.S. EPA policy.
URLs/Downloads:
DOI: SeqAPASS Version 6.0 – Integrating Ecotoxicology Data into sequence-based predictions of chemical susceptibility
SEQAPASSV6.PDF (PDF, NA pp, 6426.184 KB, about PDF)