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Probabilistic Reference and 10% Effect Concentrations for Characterizing Inhalation Non-cancer and Developmental/Reproductive Effects for 2,160 Substances
Citation:
Aurisano, N., P. Fantke, W. Chiu, R. Judson, S. Jang, A. Unnikrishnan, AND O. Jolliet. Probabilistic Reference and 10% Effect Concentrations for Characterizing Inhalation Non-cancer and Developmental/Reproductive Effects for 2,160 Substances. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 58(19):8278-8288, (2024). https://doi.org/10.1021/acs.est.4c00207
Impact/Purpose:
This study provides surrogate inhalation PODs and their corresponding probabilistic RfCs and human population effect concentrations (I = 10%) for more than two thousand chemicals, which drastically increases the chemical coverage for inhalation exposure as compared to previous studies. These results, combined with effect results for oral exposure, deliver an initial approach for consistently screening toxicity effects and impacts of chemical exposures for thousands of chemicals in various chemical assessment and management frameworks, including LCIA, chemical alternatives assessment, and high-throughput risk screening for chemical substitution and prioritization. The approach enables to prioritize potential Chemicals of Concern that deserve further scrutiny.
Description:
Chemicals assessment and management frameworks rely on regulatory toxicity values, which are based on points of departure (POD) identified following rigorous dose–response assessments. Yet, regulatory PODs and toxicity values for inhalation exposure (i.e., reference concentrations [RfCs]) are available for only ∼200 chemicals. To address this gap, we applied a workflow to determine surrogate inhalation route PODs and corresponding toxicity values, where regulatory assessments are lacking. We curated and selected inhalation in vivo data from the U.S. EPA’s ToxValDB and adjusted reported effect values to chronic human equivalent benchmark concentrations (BMCh) following the WHO/IPCS framework. With this work, we have expanded the number of chemicals with toxicity values available, thereby enabling a much broader coverage for inhalation risk and impact assessment.
URLs/Downloads:
DOI: Probabilistic Reference and 10% Effect Concentrations for Characterizing Inhalation Non-cancer and Developmental/Reproductive Effects for 2,160 Substances
https://pubmed.ncbi.nlm.nih.gov/38697947/