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Simulating Human Variability in Toxicokinetics with R Package “httk”
Citation:
Wambaugh, J., M. Breen, S. Davidson-Fritz, AND C. Ring. Simulating Human Variability in Toxicokinetics with R Package “httk”. Human In, Human Out: Using Primary and Population Data for PBPK Analyses, Virtual, NC, November 10, 2022. https://doi.org/10.23645/epacomptox.21526299
Impact/Purpose:
This is a presentation to the Human In, Human Out: Using Primary and Population Data for PBPK Analyses virtual meeting Summit scheduled for November 10. The presentation is entitled: “Simulating Human Variability in Toxicokinetics with R Package “httk””. https://us06web.zoom.us/webinar/register/WN_ZqZgN1cWQLq8giwRMEHJAQ
Description:
Learning objectives: 1) What is HTTK? 2) For what can I use HTTK? 3) How does HTTK simulate human variability? 4) On what information is HTTK human variability simulator based? HTTK allows dosimetric adjustment of high-throughput screening (HTS) data. Chemical-specific HTTK data or predictions are available for thousands of chemicals, HTTK is open source, free, and evaluated software. HTTK accounts for human population diversity using biometrics from the CDC NHANES to predict toxicokinetic model parameters. Variability is simulated using a Monte Carlo approach. Breen et al. (2022) updated R package “httk” to the most recent three NHANES cohorts and adds children under the age of 6. Toxicodynamic variability is not included. HTTK in vitro parameters are generated from pooled adult tissues.
URLs/Downloads:
DOI: Simulating Human Variability in Toxicokinetics with R Package “httk”
HUMANINHUMANOUT-HTTK-111022-DRAFT2.PDF (PDF, NA pp, 1964.653 KB, about PDF)