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US EPA’s ExpoCast program: New approach methodologies for exposure (ACTRA)
Citation:
Ring, C., K. Phillips, J. Wambaugh, AND K. Isaacs. US EPA’s ExpoCast program: New approach methodologies for exposure (ACTRA). Australasian College of Toxicology & Risk Assessment, Melbourne, N/A, AUSTRALIA, August 24 - 25, 2022. https://doi.org/10.23645/epacomptox.20432043
Impact/Purpose:
N/A
Description:
Thousands of chemicals used in commerce require screening and prioritization for potential human and ecological health risks. Chemical prioritization requires information about both hazard and exposure. To fill data gaps for exposure, US EPA’s ExpoCast program is developing a wide-ranging suite of new approach methodologies (NAMs). This presentation will provide an overview of ExpoCast exposure NAMs, which include: • Informatics approaches for organizing exposure-relevant chemical descriptors, including chemical use and occurrence • Non-targeted analysis: Analytical chemistry to rapidly identify chemicals in media • High-throughput (HT) computational models of exposure • HT consensus models of exposure that quantitatively integrate exposure information from many sources and quantify uncertainty in model predictions • HT toxicokinetics models to relate internal and external exposures • Machine-learning models to fill data gaps • Chemical prioritization workflows that integrate exposure and other NAMs
URLs/Downloads:
DOI: US EPA’s ExpoCast program: New approach methodologies for exposure (ACTRA)
RING_EXPOCAST_ACTRA_TEMPLATE_V3.PDF (PDF, NA pp, 5333.458 KB, about PDF)