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Updates on EPA-ORD-CCTE Thyroid Screening Activities and HT-H295R Steroidogenesis Model
Citation:
Paul-Friedman, K. Updates on EPA-ORD-CCTE Thyroid Screening Activities and HT-H295R Steroidogenesis Model. Organization for Economic Co-operation and Development (OECD) Endocrine Disrupters Testing and Assessment (EDTA) Advisory Group Meeting, Paris, Virtual, FRANCE, October 26 - 27, 2021. https://doi.org/10.23645/epacomptox.17108438
Impact/Purpose:
Presentation to the Organization for Economic Co-operation and Development (OECD) Endocrine Disrupters Testing and Assessment (EDTA) Advisory Group Meeting Oct 2021. To update on research activities and participate in OECD EDTA conversations related to OECD-led efforts to validate SOPs for thyroid screening assays and OECD-led conversations on the utility of steroid biosynthesis data.
Description:
Thyroid screening has been guided by the thyroid adverse outcome pathway network (as described in Noyes et al. 2019). Now, a lot of thyroid-related screening data are available from a number of high-throughput screening assays that evaluate thyroid-relevant molecular initiating events. To understand the potential utility of these data, ongoing research aims to develop and apply higher tier, confirmatory models that evaluate tissue-level effects (e.g., effects on glandular thyroid hormone synthesis or clearance of thyroid hormones from the liver). Additional research on models that connect exposure (toxicokinetics) and/or thyroid hormone kinetics may also be important for building the connections between bioactivity at the molecular initiating event level to key events that may be indicative of adversity.
URLs/Downloads:
DOI: Updates on EPA-ORD-CCTE Thyroid Screening Activities and HT-H295R Steroidogenesis Model
OECD_EDTA_THYROID_HTH295RMODEL_SESSIONS_OCT2021_KPF.PDF (PDF, NA pp, 2272.071 KB, about PDF)