Science Inventory

Updates on EPA-ORD-CCTE Thyroid Screening Activities and HT-H295R Steroidogenesis Model

Citation:

Paul-Friedman, K. Updates on EPA-ORD-CCTE Thyroid Screening Activities and HT-H295R Steroidogenesis Model. Organization for Economic Co-operation and Development (OECD) Endocrine Disrupters Testing and Assessment (EDTA) Advisory Group Meeting, Paris, Virtual, FRANCE, October 26 - 27, 2021. https://doi.org/10.23645/epacomptox.17108438

Impact/Purpose:

Presentation to the Organization for Economic Co-operation and Development (OECD) Endocrine Disrupters Testing and Assessment (EDTA) Advisory Group Meeting Oct 2021. To update on research activities and participate in OECD EDTA conversations related to OECD-led efforts to validate SOPs for thyroid screening assays and OECD-led conversations on the utility of steroid biosynthesis data.

Description:

Thyroid screening has been guided by the thyroid adverse outcome pathway network (as described in Noyes et al. 2019). Now, a lot of thyroid-related screening data are available from a number of high-throughput screening assays that evaluate thyroid-relevant molecular initiating events. To understand the potential utility of these data, ongoing research aims to develop and apply higher tier, confirmatory models that evaluate tissue-level effects (e.g., effects on glandular thyroid hormone synthesis or clearance of thyroid hormones from the liver). Additional research on models that connect exposure (toxicokinetics) and/or thyroid hormone kinetics may also be important for building the connections between bioactivity at the molecular initiating event level to key events that may be indicative of adversity. 

Record Details:

Record Type:DOCUMENT( PRESENTATION/ SLIDE)
Product Published Date:10/27/2021
Record Last Revised:12/01/2021
OMB Category:Other
Record ID: 353484