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US EPA’s ExpoCast program: New approach methodologies for exposure
Citation:
Ring, C., J. Wambaugh, AND K. Isaacs. US EPA’s ExpoCast program: New approach methodologies for exposure. Toxicology Forum Summer 2021 Virtual Meeting, Virtual, NC, July 29, 2021. https://doi.org/10.23645/epacomptox.16754728
Impact/Purpose:
Presentation to the Toxicology Forum Summer 2021 Virtual Meeting July 2021. Human exposures to individual chemicals and their mixtures that may have an adverse effect on health are multifactorial and complex. Exposure science characterizes the intensity and duration of human contact with exogenous agents and their fate in the environment and human body. Recent advances in the analytical and computational methods to conduct targeted and untargeted exposure assessment of chemicals and complex exposures have created new opportunities in both fundamental and applied/regulatory science to improve risk assessment and human health protection. This session aims to highlight recent advances in environmental exposomics, and the use of novel exposure data streams in human population studies of potential adverse health effects of chemicals. We will discuss the integration of exposure estimates, measured or predicted, with biomarkers and other data streams for linkage to health outcomes, and how the totality of this knowledge may improve decision-making in risk assessment.
Description:
There is a need to rapidly prioritize large numbers of chemicals according to potential risk. Risk is a function of both hazard and exposure, so we need to rapidly predict potential exposures. The US EPA ExpoCast project develops exposure NAMs (new approach methodologies) that 1) inform chemical use & release, fate & transport, media occurrence, pathways & routes of exposure, human receptor population, toxicokinetics, and internal dose, 2) can be applied rapidly, to large numbers of chemicals, 3) leverage existing information to make predictions for data-poor chemicals, 4) quantify uncertainty, and 5) can be used to prioritize chemicals by potential risk (in combination with NAMs for hazard/toxicity). This presentation will show examples of ExpoCast NAMs that inform consumer exposures, human aggregate exposures by various pathways, exposure model evaluation, and risk-based chemical prioritization.
URLs/Downloads:
DOI: US EPA’s ExpoCast program: New approach methodologies for exposure
RING_TOXFORUM_SUMMER2021_V6.PDF (PDF, NA pp, 4077.086 KB, about PDF)