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ESTIMATES OF AGE-SPECIFIC URINARY EXCRETION RATES FOR CREATININE AMONG CHILDREN
Citation:
EGEGHY, P. P. AND K. W. THOMAS. ESTIMATES OF AGE-SPECIFIC URINARY EXCRETION RATES FOR CREATININE AMONG CHILDREN. Presented at ISEA/ISEE 2006, Paris, FRANCE, September 02 - 06, 2006.
Impact/Purpose:
The objectives for this task are to
Compile results and important findings from NERL-sponsored children's exposure studies;
Determine which pathways produce the greatest contribution to aggregate exposure among children for specific classes of pesticides;
Identify and quantify the factors that influence pesticide exposures among children;
Develop input parameters (e.g. multimedia pesticide distributions, exposure factor data) for exposure and dose models for assessing aggregate exposures and cumulative risks;
Evaluate exposure and dose models, including algorithms for estimating route-specific exposures, against real world data; and
Identify additional data gaps for modeling aggregate exposure and dose.
Description:
The results of this study suggest that naïve adjustment by creatinine concentration, without consideration of the age-dependence of the physiological mechanisms controlling its excretion, may introduce sizeable error and is inappropriate when comparing metabolite concentrations among different age groups.