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IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Consultation Draft)
Citation:
U.S. EPA. IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Consultation Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/003C, 2011.
Impact/Purpose:
The Toxicological Review of 1,4-dioxane provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to 1,4-dioxane.
Description:
On September 9, 2011, the Toxicological Review of 1,4-Dioxane (with inhalation update) (External Review Draft) was posted for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments with EPA's response and the interagency science consultation draft of the IRIS Toxicological Review of 1,4-dioxane and the charge to external peer reviewers are posted on this site.
URLs/Downloads:
IRIS Toxicological Review of 1,4-Dioxane (Interagency Science Consultation Draft) (PDF, 401 pp, 4786 KB, about PDF)draft Charge to External Peer Reviewers (Interagency Science Consultation draft) (PDF, 3 pp, 57 KB, about PDF)
EPA's Response and Comments from the Interagency Science Consultation (PDF, 31 pp, 173 KB, about PDF)
1. CDC ATSDR 1,4-dioxane IASC Comments (PDF, 2 pp, 54 KB, about PDF)
2. DoD 1,4-dioxane IASC Comments (PDF, 16 pp, 213 KB, about PDF)
3. NASA 1,4-dioxane IASC Comments (PDF, 2 pp, 29 KB, about PDF)
4. NIEHS NTP 1,4-dioxane IASC Comments (PDF, 1 pp, 13 KB, about PDF)
5. OMB 1,4-dioxane IASC Comments (PDF, 3 pp, 27 KB, about PDF)