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THE ROLE OF ARSENIC (+3 OXIDATION STATE) METHYLTRANSFERASE IN ARSENIC METABOLISM
Citation:
DROBNA, Z., S. B. WATERS, V. DEVESA I PEREZ, W. XING, A. W. HARMON, D. J. THOMAS, AND M. STYBLO. THE ROLE OF ARSENIC (+3 OXIDATION STATE) METHYLTRANSFERASE IN ARSENIC METABOLISM. Presented at Central & Eastern European Conference on Health & the Environment, Bratislava, SLOVAKIA, October 22 - 25, 2006.
Description:
Arsenic (As) is widely distributed in the environment. Epidemiological studies have linked chronic exposures to inorganic As (iAs) to adverse health effects such as skin lesions, peripheral neuropathy, cardiovascular, hepatic and renal disorders, diabetes mellitus, skin cancer, and cancer of internal organs. In many mammalian species, iAs is metabolized to methylarsenic (MAs), dimethylarsenic (DMAs), and in some species trimethylarsenic (TMAs) metabolites that contain As in +3 (AsIII) or +5 (AsV) oxidation state.