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IRIS Assessment Plan and Protocol for Assessing Cancer Risk from Inhalation Exposure to Cobalt and Cobalt Compounds (Scoping and Problem Formulation Materials)

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Notice:

EPA announced the availability of the IRIS Assessment Plan and Protocol for Assessing Cancer Risk from Inhalation Exposure to Cobalt and Cobalt Compounds (Scoping and Problem Formulation Materials) for a 30-day public comment period as announced in the Federal Register. The deadline for comments is Dec 14, 2022. [FR Notice: Nov 14, 2022]

Citation:

U.S. EPA. IRIS Assessment Plan and Protocol for Assessing Cancer Risk from Inhalation Exposure to Cobalt and Cobalt Compounds (Scoping and Problem Formulation Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-22/248, 2022.

Impact/Purpose:

This document presents a draft IRIS Assessment Plan (IAP) and Systematic Review Protocol for Inhalation Exposure to Cobalt and Compounds (Cancer) that will be the subject of an SAB/Chemical Assessment Advisory Committee meeting in 2023 and that will define the scope and approach of the IRIS assessment for cobalt (inhalation).

Description:

In November 2022, EPA released the Draft IRIS Assessment Plan (IAP) and Protocol for Assessing Cancer Risk from Inhalation Exposure to Cobalt and Cobalt Compounds for public review and comment. An IRIS Assessment Plan (IAP) communicates to the public the plan for assessing each individual chemical and includes summary information on the IRIS Program’s scoping and initial problem formulation; objectives and specific aims for the assessment; the PECO (Populations, Exposures, Comparators, and Outcomes) criteria that outlines the evidence considered most pertinent to the assessment; and identification of key areas of scientific complexity. The PECO provides the framework for developing literature search strategies and inclusion/exclusion criteria, particularly with respect to evidence stream (i.e., human, animal, mechanistic), exposure and outcome measures. EPA also released the IRIS assessment protocol for cobalt, which describes the methodology for how the assessment will be conducted, including dose-response methods.

Record Details:

Record Type:DOCUMENT( ASSESSMENT DOCUMENT)
Product Published Date:11/10/2022
Record Last Revised:11/14/2022
OMB Category:Other
Record ID: 356084