Science Inventory

Using Zebrafish to Assess Developmental Neurotoxicity (Book Chapter)

Citation:

Padilla, S., B. Hill, J. Legradi, AND N. Klüver. Using Zebrafish to Assess Developmental Neurotoxicity (Book Chapter). Edition Third, Chapter 13, Ramesh Gupta (ed.), Reproductive and Developmental Toxicology. Academic Press Incorporated, Orlando, FL, , 239-251, (2022). https://doi.org/10.1016/B978-0-323-89773-0.00013-8

Impact/Purpose:

This chapter was written as an introduction to the use of zebrafish in developmental neurotoxicology, and to encourage the use of this model either for screening or mechanistic purposes. We have endeavored to make the reader aware of significant research findings, and to offer a balanced view of the advantages and limitations in using zebrafish as a model for investigating developmental neurotoxicity.

Description:

It is widely accepted that the developing nervous system is especially vulnerable to a variety of chemicals, including drugs and environmental contaminants; however our understanding of the risks from chemical exposures during development is rudimentary. Zebrafish have become a popular test species in toxicology, pharmacology, and biomedical research. This chapter was written as an introduction to the use of zebrafish in developmental neurotoxicology, and to encourage the use of this model either for human or ecological risk characterizations. We have endeavored to make the reader aware of significant research findings, and to offer a balanced view of the advantages and limitations in using zebrafish as a model for investigating developmental neurotoxicity.

Record Details:

Record Type: DOCUMENT ( BOOK CHAPTER)
Product Published Date: 06/06/2022
Record Last Revised: 05/13/2022
OMB Category: Other
Record ID: 354757