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Examples of How Data from in vitro Developmental Neurotoxicity Assays Are Being Used to Make Decisions About Chemicals
Citation:
Shafer, T. Examples of How Data from in vitro Developmental Neurotoxicity Assays Are Being Used to Make Decisions About Chemicals. 11th World Congress on Alternatives and Animal Use in the Life Sciences, Virtual, Maastricht, NETHERLANDS, August 23 - September 02, 2021. https://doi.org/10.23645/epacomptox.16645420
Impact/Purpose:
Presentation to the 11th World Congress on Alternatives and Animal Use in the Life Sciences (WC11) Aug 2021. Development of alternative assays for developmental neurotoxicity hazard is a high priority for evaluation of chemicals under TSCA and FIFRA. This abstract addresses the use of those assays and how those potential uses can inform scientists who are developing those assays.
Description:
Over the past decade, a concerted effort has been made to develop in vitro and alternative assays that detect compounds with the potential to cause developmental neurotoxicity. As a result, a battery of assays has been developed that is believed to be useful for decision-making regarding DNT hazard associated with chemicals. However, case-studies that apply data from these assays to environmental decision-making have yet to be developed, in part due to only a limited amount of data on particular chemical(s) or chemical classes. This presentation will present a series of hypothetical scenarios of how data from in vitro and alternative DNT assays could be used to inform decision-making regarding chemicals. These scenarios will range from simple prioritization of large numbers of compounds to more complex scenarios where both in vitro and in vivo data exist, and where exposure is also considered. Considering these theoretical scenarios is useful for two purposes. First, it can illustrate to decision-makers how data from these assays can be of utility to them. Second, and importantly for scientists in this field, it illustrates the guidance that the developers of these assays will need to provide to decision makers to facilitate their use of the data from in vitro and alternative DNT assays. (This abstract does not reflect EPA policy).
URLs/Downloads:
DOI: Examples of How Data from in vitro Developmental Neurotoxicity Assays Are Being Used to Make Decisions About Chemicals
SHAFER_WORLD CONGRESS 2021V3.PDF (PDF, NA pp, 3936.44 KB, about PDF)