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New Approach Methodologies (NAMs) and Chemical Risk Assessment
Citation:
Gwinn, M. New Approach Methodologies (NAMs) and Chemical Risk Assessment. Presentation given to the Georgetown Univ Environmental Health Risk Assessment Class, RTP, NC, April 24, 2020. https://doi.org/10.23645/epacomptox.12837488
Impact/Purpose:
Presentation given to the Georgetown University Deptartment of Chemistry/Environmental Metrology and Policy Program class: Introduction to Environmental Health Risk Assessment and Management in April 2020 by Dr. Maureen Gwinn, Division Director of the US EPA Center for Computational Toxicology and Exposure, Biomolecular and Computational Toxicology Division.
Description:
The US EPA has made great advances in the development of new approach methodologies (NAMs) for filling information gaps for decision-making and integrating those tools and data streams into chemical risk assessment. NAMs are commonly defined to include in silico approaches, in chemico and in vitro assays, as well as the inclusion of information from the exposure of chemicals in the context of hazard assessment. They may also include a variety of new testing tools, such as 'high-throughput screening' and 'high-content methods' e.g. genomics, proteomics, metabolomics; as well as some 'conventional' methods that aim to improve understanding of toxic effects, either through improving toxicokinetic or toxicodynamic knowledge for substances. The EPA has worked with other stakeholders to leverage resources and develop NAMs that can support different regulatory contexts. Building confidence in the use of NAMs for regulatory decision-making is key to the increased implementation of these methods. The views expressed are those of the author and do not necessarily reflect the views of the US EPA.
URLs/Downloads:
DOI: New Approach Methodologies (NAMs) and Chemical Risk Assessment
GW - GWINN 042420V2.PDF (PDF, NA pp, 3912.374 KB, about PDF)