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Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) version 4.0 user guide
Citation:
Lalone, C., D. Blatz, AND C. Finnegan. Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) version 4.0 user guide. U.S. EPA Office of Research and Development, Washington, DC, EPA/600/R-19/156, 2019.
Impact/Purpose:
The SeqAPASS v4.0 User Guide is a step by step manual, complete with text and visual instructions, to guide the user through all of the functionality of the publically accessible online SeqAPASS tool. The SeqAPASS tool allows users to compare protein similarity across species. This is important because chemicals act on protein targets. Therefore, by understanding how similar proteins are across species, the SeqAPASS tool can produce chemical susceptibility predictions across hundreds of species rapidly.
Description:
User Guide to describe the complete functionality of the Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) Version 4.0 online tool. The US Environmental Protection Agency Sequence Alignment to Predict Across Species Susceptibility tool (SeqAPASS; https://seqapass.epa.gov/seqapass/) was developed to comparatively evaluate protein sequence and structural similarity across species as a means to extrapolate toxicity data/knowledge. SeqAPASS output provides a prediction of chemical susceptibility based on principles of evolutionary biology in understanding species relatedness at the molecular level.