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Review of Bacillus anthracis Dose Response Data for Human Health Risk Assessment
Hines, S. Review of Bacillus anthracis Dose Response Data for Human Health Risk Assessment. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-16/147, 2016.
The report is designed to support the development of a site-specific human health risk assessment (HHRA) for Bacillus anthracis using available open source data and analysis approaches. The content reflects the output of an agent-specific planning activity for B. anthracis to identify and evaluate published dose-response data, identify data gaps and process gaps for microbial dose-response analysis of the agent, and identify science policy gaps that may need to be filled to conduct a site-specific HHRA for the agent.
Interest in low-dose dose-response relationships for Bacillus anthracis exposure can be traced to data gaps made apparent during the civilian response to the 2001 anthrax letter event. This report conducts a systematic review of Bacillus anthracis dose-response data that can be used to inform development of a dose-response relationship or to support the use of Bacillus anthracis dose-response data in a human health risk assessment.
URLs/Downloads:REVIEW OF BACILLUS ANTHRACIS DOSE RESPONSE DATA FOR HUMAN HEALTH RISK ASSESSMENT (PDF,249 pp, 2552 KB, about PDF)
Record Details:Record Type: DOCUMENT (PUBLISHED REPORT/REPORT)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HOMELAND SECURITY RESEARCH CENTER
THREAT AND CONSEQUENCE ASSESSMENT DIVISION