Science Inventory

Experiments with the LECO Pegasus® Gas Chromatograph/Time-of-Flight Mass Spectrometer Phase 2: 2D Fast GC Separations

Citation:

Campisano, R. Experiments with the LECO Pegasus® Gas Chromatograph/Time-of-Flight Mass Spectrometer Phase 2: 2D Fast GC Separations. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-16/124, 2016.

Impact/Purpose:

The analytes studied in this report were sulfur mustard (HD), sarin (GB), soman (GD), cyclosarin (GF), and O-ethylS-[2-(diisopropylamino)ethyl] methylphosphonothioate (VX). 2D GC/TOF-MS was shown to provide fast separations and produce lower instrument detection limits by approximately a factor of 1020, compared to the speed of analysis and instrument detection limits obtained by a quadrupole GC/MS.

Description:

Gas chromatography/mass spectrometry (GC/MS) is the method of choice for the analysis of volatile and semivolatile organic compounds in environmental samples. In this study, the LECO Pegasus® 4D GC/TOF-MS was used in the 2D mode to detect chemical warfare agents (CWAs) and to compare this instrument’s performance, with regards to speed of analysis, instrument detection limits, and various matrices to conventional quadrupole-based GC/MS.

URLs/Downloads:

EXPERIMENTS WITH THE LECO PEGASUS® GAS CHROMATOGRAPH/TIME-OF-FLIGHT MASS SPECTROMETER PHASE 2: 2D FAST GC SEPARATIONS   (PDF,42 pp, 1898 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (PUBLISHED REPORT/REPORT)
Product Published Date: 06/01/2016
Record Last Revised: 09/11/2019
OMB Category: Other
Record ID: 346588

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HOMELAND SECURITY RESEARCH CENTER

THREAT AND CONSEQUENCE ASSESSMENT DIVISION