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Untangling the Web of Chemicals Exposures and Public Health Risk
Citation:
Wambaugh, J. Untangling the Web of Chemicals Exposures and Public Health Risk. Presented at ECU Department of Public Health Seminar, Greenville, North Carolina, April 16, 2019. https://doi.org/10.23645/epacomptox.8014622
Impact/Purpose:
This is a graduate student seminar for the East Carolina University Department of Public Health.
Description:
We would like to know more about the risk posed by thousands of chemicals in the environment – which ones should we start with? High throughput screening (HTS) provides one path forward for identifying potential hazard, but the real world is complicated by toxicokinetics, mixtures, variability (and more). Using in vitro methods developed for pharmaceuticals, we can make useful predictions of TK for large numbers of chemicals. Exposure predictions and data are key to risk-based prioritization. Although exposure is a complex system, certain patterns emerge – in particular, near field (in the home) sources of exposure are important. Consensus modeling provides one path forward, but only as good as available data (at best). Exposure-based priority setting allows the identification of the chemicals most likely to be relevant to the public health.
URLs/Downloads:
DOI: Untangling the Web of Chemicals Exposures and Public Health Risk
ECU-WAMBAUGH-041619.PDF (PDF, NA pp, 9439.324 KB, about PDF)