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DIOXINS, MALE PUBERTAL DEVELOPMENT AND TESTIS FUNCTION (R829437)
The objectives of this project are to investigate the relationships between dioxins and male reproductive tract malformations, male pubertal development and alterations in testis function. We hypothesize that dioxins, measured in adolescence prior to the onset of puberty, are associated with disturbances in physical growth, sexual maturation (age of onset and tempo), and testis function as an adult, specifically alterations in reproductive hormones and semen quality. We also hypothesize that in utero levels of dioxins are associated with alterations in physical growth and sexual maturation in boys. In utero dioxin levels will be estimated using the childs' current serum dioxin level, as well as historical reproductive (e.g., breast feeding) and residential information. In addition, the study will investigate whether in utero levels of dioxins are associated with reproductive tract abnormalities, specifically hypospadias and cryptorchidism.
Record Details:Record Type: PROJECT (ABSTRACT)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL CENTER FOR ENVIRONMENTAL RESEARCH
ENVIRONMENTAL ENGINEERING RESEARCH DIVISION