Citation:

DiGiani, F., M. Maeker, T. Champlin, AND M. Frey. TOXICITY REDUCTION EVALUATION: CASE HISTORIES AT HIGH POINT AND FAYETTEVILLE, NORTH CAROLINA. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/R-92/184 (NTIS PB92222231).

Description:

This research focused on investigation of two important elements of the toxicity reduction evaluation (TRE) protocol proposed by EPA: 1) toxicity identification evaluation (TIE) and (2) toxicity source evaluation (TSE). he specific objectives were to: hallenge the TIE protocol with target compounds to determine whether the toxicity could be properly classified; apply the TIE and TSE protocols to two case studies (High Point, NC and Fayetteville, NC) where pass-through toxicity was highly variable; and investigate the potential for return activated sludge to desorb components that may cause acute toxicity. lution of the C18 column with methanol/water fraction (TIE Phase II) showed that a single toxic compound may appear in several different elution fractions. ost of the toxicity was found in the 80% to 85% methanol fractions, indicating that the toxic compounds were relatively nonpolar. assage of toxic samples through a C18 SPE column removed acute toxicity completely in each instance. he refractory toxicity assessment (RTA) protocol was modified to identify chronic toxicity as the end-point rather than acute toxicity. esults indicated that the TIE Phase I protocol can provide proper direction for further narrowing of potential toxicants but more data are needed on mixtures of target compounds to show reliability.

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