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Development and application of an LC-MS/MS method for the detection of the vinyl chloride-induced DNA adduct N2,3-ethenoguanine in tissues of adult and weanling rats following the exposure to [13C2]-VC
Citation:
Mutlul, E., L. B. Collins, M. D. Stout, P. B. Upton, D. W. WINSETT, G. E. HATCH, P. A. EVANSKY, AND J. A. Swenberg. Development and application of an LC-MS/MS method for the detection of the vinyl chloride-induced DNA adduct N2,3-ethenoguanine in tissues of adult and weanling rats following the exposure to [13C2]-VC. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 23(9):1485-1491, (2010).
Impact/Purpose:
to develop an application of an LC-MS/MS method
Description:
In the 1970s exposure to vinyl chloride (VC) was shown to cause liver angiosarcoma in VC workers. We have developed a new LC-MS/MS method for analyzing the promutagenic DNA adduct N2,3-ethenoguanine and have applied this to DNA from tissues of both adult and weanling rats exposed to 1110 ppm [13C2]-VC for 5 days or 1100 ppm VC for 1 day.
