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A RANDMONIZED, CONTROLLED TRIAL OF IN-HOME DRINKING WATER INTERVENTION FOR THE REDUCTION OF GASTROINTESTINAL ILLNESS.
Colford, J. M., T. J. Wade, S. Sandhu, S. Lee, S. Shaw, K R. Fox*, S. Burns, A. Benker, A. Brookhart, M. van der Laan, AND D. Levy. A RANDMONIZED, CONTROLLED TRIAL OF IN-HOME DRINKING WATER INTERVENTION FOR THE REDUCTION OF GASTROINTESTINAL ILLNESS. AMERICAN JOURNAL OF EPIDEMIOLOGY. Johns Hopkins Bloomberg School of Public Health, 161(5):472-482, (2005).
Trials have provided conflicting estimates of the risk of gastrointestinal illness attributable to tap water. To estimate this risk in an Iowa community with a well-run water utility with microbiologically challenged source water, the authors of this 2000-2002 study randomly assigned blinded volunteers to use externally identical devices (active device: 227 households with 646 persons; sham device: 229 households with 650 persons) for 6 months (cycle A). Each group then switched to the opposite device for 6 months (cycle B). The active device contained a 1-microm absolute ceramic filter and used ultraviolet light. Episodes of "highly credible gastrointestinal illness," a published measure of diarrhea, nausea, vomiting, and abdominal cramps, were recorded. Water usage was recorded with personal diaries and an electronic totalizer. The numbers of episodes in cycle A among the active and sham device groups were 707 and 672, respectively; in cycle B, the numbers of episodes were 516 and 476, respectively. In a log-linear generalized estimating equations model using intention-to-treat analysis, the relative rate of highly credible gastrointestinal illness (sham vs. active) for the entire trial was 0.98 (95% confidence interval: 0.86, 1.10). No reduction in gastrointestinal illness was detected after in-home use of a device designed to be highly effective in removing microorganisms from water.
To better estimate the risk of gastrointestinal illness attributable to tap water.
Record Details:Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB
HUMAN STUDIES DIVISION
EPIDEMIOLOGY AND BIOMARKERS BRANCH