You are here:
EFFECTS OF SUBCHRONIC EXPOSURES TO CONCENTRATED AMBIENT PARTICLES: VII. DEGENERATION OF DOPAMINERGIC NEURONS IN APO E-/- MICE.
Veronesi, B, O. Makwana, M. Pooler, AND L. C. Chen. EFFECTS OF SUBCHRONIC EXPOSURES TO CONCENTRATED AMBIENT PARTICLES: VII. DEGENERATION OF DOPAMINERGIC NEURONS IN APO E-/- MICE. INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, 17:235-241, (2005).
This research describes the neuropathological consequences of subchronic exposure to particulate matter. A genetically modified animal strain (Apo E-/-) which expresses high levels of oxidative stress was exposed to ambient NYC air for 4-6 months. The brains of these animals were processed histologically and revealed neuropathic damage to the same type of neurons that degenerate in parkinsons disease. This demonstration underscores the serious interaction between the health condition of oxidative stress and exposure to chemicals that in themselves convey oxidative stress
Record Details:Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB
CELLULAR AND MOLECULAR TOXICOLOGY BRANCH