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Advancing New Approach Methodologies (NAMs) for Tobacco Harm Reduction: Synopsis from the 2021 CORESTA SSPT – NAMs symposium
Citation:
Lee, K., R. Corley, A. Jarabek, N. Kleinstreuer, A. Paini, A. Stucki, AND S. Bell. Advancing New Approach Methodologies (NAMs) for Tobacco Harm Reduction: Synopsis from the 2021 CORESTA SSPT – NAMs symposium. Toxics. MDPI, Basel, Switzerland, , 25, (2022). https://doi.org/10.3390/toxics10120760
Impact/Purpose:
This paper provides a summary of a session convened by the Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA) at its 2021 Smoke Science and Product Technology (SSPT) conference. The session entitled “Advancing New Alternative Methods for Tobacco Harm Reduction”, was devoted to defining and explaining the state of the science for novel approach methodologies (NAMs). Case studies were used to illustrate challenges and opportunities for their application to the assessment of the application of novel approach methodologies (NAMs) for evaluation of various rapidly emerging tobacco products.
Description:
" New Approach Methodologies (NAMs) are emerging chemical safety assessment tools consisting of in vitro and in silico (computational) methodologies, intended to reduce, refine, or replace (3R) various in vivo animal testing methods traditionally used for risk assessment. Significant progress has been made toward the adoption of NAMs for human health and environmental toxicity assessment. However, additional efforts are needed to expand their development and their use in regulatory decision making.
URLs/Downloads:
DOI: Advancing New Approach Methodologies (NAMs) for Tobacco Harm Reduction: Synopsis from the 2021 CORESTA SSPT – NAMs symposium