Science Inventory

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New approach methodologies (NAMs) are being evaluated for their utility to inform developmental neurotoxicity (DNT) hazard instead of using animals. This work compares predictive models for DNT using DNT NAMs data. The dataset comprised 200 chemicals screened in 17 DNT assays wit...

As the risks of climate change impacts become more apparent and more severe, communities need ways to plan, adapt, and transform in order to increase resilience. Disasters cause widely disparate impacts on communities and populations with differential vulnerability, making necess...

This poster, &ldquo;Building Factors Influencing Indoor Air Quality During Wildfire Smoke Events,&rdquo; provides an overview of the results and significance of a field study conducted in Missoula County, MT examining indoor air quality in public and commercial buildings during a...

Communities across the world are experiencing a myriad of impacts from intensifying extreme heat, flood, drought, and wildfire events due to climate change. Further impacts can be experienced due to nearby contaminated sites and waste management facilities that are either activel...

Read-across is a data-gap filling technique utilised to predict the toxicity of a target chemical using data from similar analogues. Read-across is predominantly performed as part of an expert-driven assessment which can impeded broad acceptance. Data-driven approaches such as Ge...

Background and Purpose: Health effects of inhaled smoke from military burn pits include increased incidences of cardiopulmonary diseases, sinonasal disease, and cancers of the nervous system. Burn pit smoke is a complex mixture of particulate matter (PM), volatile organic compoun...

Journal article submitted to EcoHealth - (Abstract) - Lyme disease (LD) is the most common vector-borne disease in the United States (U.S.). This paper assesses how climate change may influence LD incidence in the eastern and upper midwestern U.S., and the associated economic bur...

Permafrost soils store &sim;50% of terrestrial C, with Yedoma permafrost containing &sim;25% of the total C. Permafrost is undergoing degradation due to thawing, with potentially hazardous effects on landscape stability and water resources. Complicating ongoing efforts to project...

Career Day at East Cary Magnet Middle School

Brief overview of Earth Observation science and water quality for middle to high school age children.

Concern over exposure to and potential health effects of per- and polyfluoroalkyl substances (PFAS) continues to increase as more is learned about their environmental persistence and human bioaccumulative potential. With PFAS estimates ranging to over 10,000, the limited exposure...

Climate change presents cascading and compounding threats to low-income and underrepresented communities, increasing the need for equitable resilience planning. However, many local governments face challenges incorporating community voices with resilience and vulnerability data i...

Before the era of fossil fuel use, water provided power for industrial processes in the USA through a ubiquitous network of dams and mills. This infrastructure was constructed concurrently with widespread deforestation and sedimentation during the 18th through 20th centuries caus...

The increasing trend in the frequency and intensity of extreme precipitation events and associate flooding has been well documented within the Southeastern U.S. using the historical climate records. Studies also describe dramatic ecosystem responses to extreme events with a plaus...

Adverse outcome pathways (AOPs) are a framework for organizing scientific information concerning the linkage between biological perturbations measured at low levels of biological organization (e.g., molecular, biochemical, cellular) and adverse effects of concern for risk assessm...

This book chapter addresses the topic of chemical toxicokinetics in fish. Introductory sections provide an overview of chemical absorption, distribution, and excretion, and highlight how adaptations of fish to their aquatic environment shape these processes. An extended section o...

Enhanced Aquifer Recharge (EAR) is the process of enhancing the natural conveyance of water into the subsurface to augment water supplies. Karst geology offers a natural mechanism for recharge and covers 20% of the U.S. land surface. The potential impacts to groundwater flow foll...

Neurite outgrowth is an important precursor to synapse formation and assays for neurite outgrowth are part of an in vitro battery (IVB) of assays for developmental neurotoxicity screening (DNT). This battery of assays evaluates chemical effects on key neurodevelopmental processes...

Neurite outgrowth is an important precursor to synapse formation and assays for neurite outgrowth are part of an in vitro battery (IVB) of assays for developmental neurotoxicity screening (DNT). This battery of assays evaluates chemical effects on key neurodevelopmental processes...

Background:&nbsp; Xenobiotic metabolites are widely present in human urine and can indicate recent exposure to environmental chemicals. Proper inference of which chemicals contribute to these metabolites can inform human exposure and risk. Furthermore, longitudinal biomonitoring...

Presentation for the AWMA Science of PFAS Conference on characterizing PFAS thermal treatment using online mass spectrometry. In this presentation previously published results from EPA's Rainbow furnace will be discussed to provide context on formation of products of incomplete c...

Aqueous film-forming foams (AFFFs) are used in firefighting applications, and often contain per- and polyfluoroalkyl substances (PFAS), which can detrimentally impact environmental and biological health. Incineration is a potential disposal method for AFFFs, which may produce sec...

In urban systems, a wide variety of processes, including increasing impervious surface cover, road salt application, sewage leaks, and weathering of the built environment, contribute to novel chemical cocktails that are comprised of metals, salts, nutrients, and organic matter. D...

In urban systems, a wide variety of processes, including increasing impervious surface cover, road salt application, sewage leaks, and weathering of the built environment, contribute to novel chemical cocktails that are made up of metals, salts, nutrients, and organic matter. Due...

This invited keynote presentation provides compressive definitions regarding sustainable development, sustainability assessment and design, life cycle analysis, and their application in manufacturing more environmentally friendly chemicals with less occupational exposure. Similar...