Science Inventory

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The US EPA has developed a set of annual North American anthropogenic and fire emissions data for criteria air pollutants across 18 broad source catagories for 2002 through 2017.  The sixteen new annual emissions inventories were developed using consistent input data and met...

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Brain health is a major individual and community issue with impacts on quality of life for the individual and economic wellbeing of the nation. The need to assess and protect the nervous system demands enhancement of biomarker development and the application of precision medicine...

Background and Purpose: Per- and polyfluoroalkyl substances (PFAS) are widely used in non-stick coatings, firefighting foams and other products. Their fluorinated state contributes to their unique uses and stability, but also may result in long half-lives in the environment and h...

Per- and polyfluoroalkyl substances (PFAS) are widely used, and their fluorinated state contributes to unique uses and stability but also long half-lives in the environment and humans. PFAS have been shown to be toxic, leading to immunosuppression, cancer, and other adverse healt...

Background/Purpose The US EPA has developed a tiered testing strategy, including high-throughput transcriptomics (HTTr) testing, to identify molecular targets of thousands of environmental chemicals. These findings can be linked to adverse outcomes and can be used in Integrated A...

Seagrass beds provide key benefits, including playing a critical role in climate mitigation. We tested the effects of different eelgrass densities on greenhouse gas (GHG) fluxes at the water-atmosphere interface by creating six treatments (4 reps ea) with different shoot densitie...

Background and Purpose: T cell receptor (TCR)-dependent activation of T cells dictates immune specificity and establishes immunological memory, key features of adaptive immunity. Canonical activation of T cells occurs through engagement of TCRs by interaction with the major histo...

Assaying for thyroid interference is of increasing importance in standardized developmental and reproductive toxicity studies. While serum T4 quantification is an endpoint assessed in developing rats, it is unclear how this measure may correlate to adverse neurodevelopmental outc...

To identify U.S. lead exposure risk hotspots, we expanded upon geospatial statistical methods from a published Michigan case study. Evaluation of identified hotspots using six lead indices, based on housing age and sociodemographic data, showed moderate-to-substantial agreement w...

Global shifts in climatic conditions and anthropogenic disturbances are dramatically modifying the Earth’s ecosystem. Ensuring water security, availability, and quality within this context largely depends on how accurately we can map Global Surface Water Extents (GWSE). Map...

Background and Purpose Biosolids are treated sewage sludge produced as a byproduct of the wastewater treatment process, often applied to land or disposed of in landfills. Under the Clean Water Act, the US EPA Office of Water (OW) has the responsibility to protect human health and...

Background: The Toxic Substances Control Act (TSCA) requires the US Environmental Protection Agency (EPA) to evaluate the hazard and exposure to new and existing chemicals. New chemical notifications are typically data poor and EPA?s Office of Pollution Prevention and Toxics (OPP...

South Florida is a subtropical environment with diverse ecological and human communities that rely on a complex water system undergoing the costliest restoration in U.S. history. Pesticide and metal input to the aquatic systems of South Florida can impact the capabilities of main...

Read-across is a data-gap filling technique utilised to predict the toxicity of a target chemical using data from similar source analogues. Read-across acceptance remains an issue, mainly due to the difficulties of addressing residual uncertainties and because read-across is stil...

Background: Observational epidemiologic studies provide critical data for the evaluation of the potential effects of environmental, occupational and behavioural exposures on human health. Systematic reviews of these studies play a key role in informing policy and practice. System...

High-throughput transcriptomics (HTTr) is increasingly being used to identify molecular targets of chemicals that can be linked to adverse outcomes. Cell proliferation is an important key event in chemical carcinogenesis. Here, we describe the construction and characterization of...

Coastal areas are important places to live, work, play, and more. They are areas with high social and economic value, but also with considerable commercial and private uses which lead to conflicts, disproportionately affected communities, and complex environmental decision making...

Over the last 10 years the EPA has been conducting research to better quantify the magnitude of greenhouse gas emissions from US reservoirs.   In 2021 reservoirs were included in the Inventory of US Greenhouse Gas Emissions and Sinks for the first time and currently estimate...

Background and Purpose: Adrenergic receptors (AR) are the most extensive therapeutically manipulated drug receptors in the treatment of respiratory diseases, such as asthma and chronic obstructive pulmonary disease. The airways are densely innervated by AR, which are cellular rec...

Several related research efforts are in-progress in the US EPA to inform a large(r) hazard and dose-response landscape for per- and polyfluoroalkyl substances (PFAS); such data may be critical to informing data-poor mixture PFAS. The expressed objective is to identify dose-respon...

While SWMM has arguably played a pivotal role in pollution control in collection systems since its introduction, traditional applications using the model have been relatively static. They typically involve calibrating and validating SWMM models with data collected and curated for...

This is a presentation abstract for proposed session, ID 141, Advances in New Approach Methods for Thyroid Toxicity Testing, for the SOT 2024 Annual Meeting.  Abstract: There is significant regulatory need to evaluate chemicals that may disrupt the thyroid endocrine system. ...

Chemical safety assessment begins with defining the lowest level of chemical that alters one or more measured endpoints. This critical effect level, along with factors to account for uncertainty, is used to derive limits for human exposure. In the absence of data regarding the sp...

This is a broad overview presentation covering CEMM's ambient and near-source air measurement research for an international audience. The presentation includes content related to Federal Reference Methods (FRMs) and Federal Equivalent Methods (FEMs) for the NAAQS, air sensor tech...