Related Topics: Health Research

Health Research Products in the Science Inventory

Records 1 to 25 of 4505

MEtabolomics standaRds Initiative in Toxicology (MERIT) (PRESENTATION)
The MEtabolomics standaRds Initiative in Toxicology (MERIT) is a European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) supported project to provide guidance on best practice, quality standards and the reporting of analytical and computational metabolomics methods...
Human Health Toxicity Values for Perfluorobutane Sulfonic Acid (CASRN 375-73-5) and Related Compound Potassium Perfluorobutane Sulfonate (CASRN 29420-49-3) (ASSESSMENT DOCUMENT)
The human health toxicity assessment document for PFBS/K+PFBS identifies and characterizes the health hazards of these chemicals and includes information to address the first two steps of the risk assessment process: hazard identification and dose-response.
Application of a density dependent logistic matrix model to investigate the effects of chemical stress and resource limitation on fish populations (PRESENTATION)
Matrix population models are useful tools for ecological risk assessment because they integrate effects across the life cycle, link endpoints observed in the individual and ecological risk to the population, and project outcomes for many generations in the future. The Atlantic ki...
20180531 - Risk Assessment Careers at the US EPA (SOT Postdoc Talk) (PRESENTATION)
This presentation gives an overview of what a career in risk assessment at the US EPA entails. Topics covered included 'what do risk assessors do', skills required for the job, responding to community emergencies, accelerating the pace of chemical evaluation, and how toxocology i...
20180203 - Concentration-Response Screening of Environmental Chemicals for In Vitro Point-of-Departure Determination using a Targeted RNA-Seq Whole Transcriptome Assay (SLAS) (PRESENTATION)
Current initiatives in environmental toxicology include integrating toxicity testing data from in vitro and alternative methods into risk assessment practices. Previously, in vitro point-of-departure (PODs) estimates suitable for use in screening-level risk assessments have been ...
20180531 - A Career in Risk Assessment: Working as a Regulatory Scientist (SOT Postdoc Talk) (PRESENTATION)
The National Research Council (1983) identified chemical risk as a function of both inherent hazard and exposure. To address thousands of chemicals, we need to use “high throughput methods” to prioritize chemicals for additional study. High throughput risk prioritizat...
20180416 - Applying a Tiered Risk-based Approach to Prioritizing Thousands of Chemicals for Further Evaluation: A Comparison of Current High Throughput Computational Approaches (SETAC Durham) (PRESENTATION)
There is a need to prioritize thousands of environmental chemicals for further testing with the help of current computational technologies. Here we present a case study on applying a risk-based approach to chemical prioritization based on an initial triage by ranking the ratios b...
Application of Quantitative Dose-Response Data in Risk Assessment and the Incorporation of High-Throughput Data (BOOK CHAPTER)
Book Chapter—This invited contribution is the concluding chapter of this important reference book. It brings together concepts discussed in preceding chapters so that the reader understands how to quantify and apply reliable findings in health risk assessment decisions.
Integrated Science Assessment (ISA) for Oxides of Nitrogen, Oxides of Sulfur and Particulate Matter Ecological Criteria (Second External Review Draft) (ASSESSMENT DOCUMENT)
This draft Integrated Science Assessment (ISA) represents a concise synthesis and evaluation of the most policy-relevant science and will ultimately provide the scientific bases for EPA’s decision on retaining or revising the current secondary standards for NO<sub>2</sub>, SO<sub...
Accelerating the Pace of Chemical Risk Assessment (PRESENTATION)
This follow up to a 2016 international workshop continues to bring together international regulators to discuss progress and barriers in applying new approach methods (NAMs) to prioritization, screening, and quantitative risk assessment. Updates to ongoing collaborative case stud...
Retrofitting an Estrogen Receptor Transactivation Assay with Metabolic Competence Using Alginate Immobilization of Metabolic Enzymes (AIME) (PRESENTATION)
The ToxCast program has faced scrutiny as the majority of the HTS assays are deficient for xenobiotic metabolism. The challenge is to develop a method that is capable of retrofitting existing cell-free and cell-based high-throughput screening assays with metabolic competence. Ris...
Examining the Utility of In Vitro Bioactivity as a Conservative Point of Departure: A Case Study (PRESENTATION)
This gives an overview of an international case study on advancing the pace of chemical risk assessment (APCRA) that asks if in vitro bioactivity can be used to derive a conservative point-of-departure (POD) for prioritization and screening level risk assessment. When combined wi...
Development of a Human Thyroid Microtissue Model for Evaluation of Thyroid Hormone Synthesis (PRESENTATION)
Risk assessment is a four step process that integrates hazard, dose-response, and exposure. Risk management incorporates additional factors related to risk characterization to set appropriate response. The EPA's National Center for Computational Toxicology utilizes a strategy for...
Accelerating the Pace of Chemical Risk Assessment Workshop: Advancing Progress in the Use of New Alternative Methods for Regulatory Support (PRESENTATION)
The tides of acceptance of new alternative methods (NAMs) are changing. Numerous scientific papers have been published recently that explore the boundaries of data applicability and propose approaches that bridge new and conventional methods. The modernization of the Toxic Substa...
The EPA CompTox Chemistry Dashboard: A Web-Based Data Integration Hub for Environmental Chemistry and Toxicology Data (PRESENTATION)
The U.S. Environmental Protection Agency (EPA) Computational Toxicology Program integrates advances in biology, chemistry, and computer science to help prioritize chemicals for further research based on potential human health risks. This work involves computational and data drive...
Moving Towards an Integrated Alternative Testing Paradigm to Identify Carcinogenic Hazards (PRESENTATION)
The prediction of cancer hazard is confounded by limited data in relevant species. Using rodent cancer bioassay data as a benchmark is confounded by significant cross-species differences, temporal dependence, and limited reproducibility. Mechanistic approaches that use machine le...
RED Project: High Throughput Toxicokinetics (HTTK) and Systematic Empirical Evaluation of Exposure (SEEM) (PRESENTATION)
This presentation provided an overview of high throughput toxicokinetics (HTTK) and systematic empirical evaluation of models (SEEM) for high throughput exposure forecasting.
The EPA CompTox Chemistry Dashboard: A Web-Based Data Integration Hub (PRESENTATION)
The U.S. Environmental Protection Agency (EPA) Computational Toxicology Program integrates advances in biology, chemistry, and computer science to help prioritize chemicals for further research based on potential human health risks. This work involves computational and data drive...
The EPA CompTox Chemistry Dashboard: A Web-Based Data Integration Hub (PRESENTATION)
The U.S. Environmental Protection Agency (EPA) Computational Toxicology Program integrates advances in biology, chemistry, and computer science to help prioritize chemicals for further research based on potential human health risks. This work involves computational and data drive...
Quantitative Structure Activity Relationships: An overview (PRESENTATION)
Chemical risk assessment of the toxic effects posed by xenobiotics is often limited by the lack of experimental toxicology data on a large number of diverse chemicals. In the absence of experimental data, data gap filling techniques such as quantitative structure activity relatio...
Incorporating High-Throughput In Vitro Bioactivity and Toxicokinetics with Predicted Exposure to Advance Screening-Level Human Health Risk Assessment (PRESENTATION)
Tens of thousands of chemicals are currently in commerce, and hundreds more are introduced every year, but only a small fraction of chemicals have been adequately evaluated for potential human health effects due to resource-intensive methods. Use of high-throughput, in vitro bio...
Chemical Priority Setting in the 21st Century (PRESENTATION)
We would like to know more about the risk posed by thousands of chemicals in the environment – which ones should we start with? High throughput screening (HTS) provides a path forward for identifying potential hazard. Exposure and dosimetry provide real world context to hazards i...
Development of QSAR Models to Predict Systemic Toxicity Points of Departure (PRESENTATION)
Human health risk assessment associated with environmental chemical exposure is limited by the tens of thousands of chemicals little or no experimental in vivo toxicity data. Data gap filling techniques, such as quantitative structure activity relationship (QSAR) models based on ...
EPA and EFSA Benchmark Dose Guidance (PRESENTATION)
Benchmark dose (BMD) modeling has become the preferred approach in the analysis of toxicological dose-response data for the purpose of deriving human health toxicity values. The software packages most often used are Benchmark Dose Software (BMDS, developed by EPA) and PROAST (de...
IRIS Assessment Plan for Naphthalene (Scoping and Problem Formulation Materials) (IRIS ASSESSMENT)
In July 2018, EPA released the <i>IRIS Assessment Plan (IAP) for Naphthalene</i> for public review and comment. An IRIS Assessment Plan (IAP) communicates to the public the plan for assessing each individual chemical and includes summary information on the IRIS Program’s scoping...