Related Topics: Health Research

Health Research Products in the Science Inventory

Records 1 to 25 of 3146

Epigenetic Mechanism Mediating the Regulation of the Estrogen Exposure Biomarker Vitellogenin in Zebrafish (PRESENTATION)
An increasing number of pharmaceuticals and industrial chemicals are being classified as endocrine disrupting compounds (EDCs). These chemicals can interfere with hormonal homeostasis and lead to developmental disorders, cancer and other pathologies. One such EDC is 17α-et...
A Review of Non-Chemical Stressors and Their Importance in Cumulative Risk Assessment (PRESENTATION)
Cumulative exposure/risk assessments need to include non-chemical stressors as well as human activities and chemical data. Multiple stressor research can offer information on the interactions between chemical and non-chemical stressors needed for cumulative risk assessment resea...
Modeling the Environmental Fate of Graphene Oxide and Its Phototransformation Products in Brier Creek Watershed Using the Water Quality Analysis Simulation Program 8 (WASP8) (PRESENTATION)
The production of graphene-family nanoparticles (GFNs) appreciably increased in recent years. Among GFNs, graphene oxide (GO) is one of the most highly studied members due to its inexpensive synthesis cost compared to graphene, its stability in aqueous media and its broad applica...
Integrated Science Assessment (ISA) for Sulfur Oxides – Health Criteria (Final) (PUBLISHED REPORT)
The final report of the <em>Integrated Science Assessment for Sulfur Oxides– Health Criteria</em> is now available. This report provides EPA’s evaluation and synthesis of the most policy-relevant science related to the health effects of sulfur oxides and provides a critical part ...
IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Preliminary Assessment Materials) (IRIS ASSESSMENT)
In August 2013, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for RDX to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in c...
The value of nature: Economic, intrinsic, or both? (JOURNAL)
There has been a long standing argument that ecosystems have intrinsic value and therefore there is no need to put a price tag on Mother Nature. The concept of intrinsic value reflects the perspective that nature has value in its own right, independent of human uses. Intrinsic va...
IRIS Toxicological Review of Tert-Butyl Alcohol (Tert-Butanol) (Preliminary Assessment Materials) (IRIS ASSESSMENT)
In August 2013, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for TBA to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in c...
IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE) (Interagency Science Consultation Draft) (IRIS ASSESSMENT)
In September 2016, EPA released the draft IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE) for public comment and discussion. The draft assessment was reviewed internally by EPA and by other federal agencies and White House Offices before public release. Consistent ...
Comparisons of Spatial Predictions of Conductivity on a Stream Network in an Appalachian Watershed (PRESENTATION)
We made spatial predictions of specific conductance based on spatial stream network (SSN) modeling to compare conductivity measurements of components of the network, such as headwaters, tributaries, and mainstem, which have different spatial extents in a study Appalachian watersh...
New applications in EPA’s ECOTOX Knowledge System: Assimilating relative potencies of metals across chemical and biological species from literature-based toxicity effects data. (PRESENTATION)
Toxicity of metals in field settings can vary widely among ionic chemical species and across biological receptors. Thus, a challenge often found in developing TRVs for the risk assessment of metals is identifying the most appropriate metal and biological species combinations for...
Using bioavailability to assess contaminated sediment risk: Passive sampling and Pore Water Remedial Guidelines (PWRGs) (PRESENTATION)
Hosted by the Contaminated Sediment Forum, this half-day course will introduce the RPM to the use of passive samplers to assess bioavailability and in ecological risk assessment. Passive sampling devices (PSD) are a technology with growing acceptance for measuring porewater conce...
Finding Toxicological Tipping Points from High-Content Imaging Data (WC10) (PRESENTATION)
A key challenge to using in vitro data in risk assessment is differentiating between chemical-induced adaptive versus adverse cellular responses. To further investigate this issue, we studied the effects of hundreds of chemicals in HepG2 cells using high-content imaging (HCI). HC...
EPA and EFSA approaches for Benchmark Dose modeling (PRESENTATION)
Benchmark dose (BMD) modeling has become the preferred approach in the analysis of toxicological dose-response data for the purpose of deriving human health toxicity values. The software packages most often used are Benchmark Dose Software (BMDS, developed by EPA) and PROAST (de...
Identification of Hotspots of Genetic Risk for Type 2 Diabetes Using GIS Methods (PRESENTATION)
BACKGROUND: Having the ability to scan the entire country for potential &quot;hotspots&quot; with increased risk of developing chronic diseases due to various environmental, demographic, and genetic susceptibility factors may inform risk management decisions and enable better env...
Systematic Review: Concept and Tool Development with Application in the Integrated Risk Information System (IRIS) Assessment Process (PRESENTATION)
Systematic Review: Concept and tool development with application to the National Toxicology Program (NTP) and the Integrated Risk Information System (IRIS) Assessment Processes. There is growing interest within the environmental health community to incorporate systematic review m...
Effects of chlorpyrifos and trichloropyridinol on HEK 293 human embryonic kidney cells (JOURNAL)
Chlorpyrifos (CPF) [O, O-diethyl -O-3, 5, 6-trichloro-2-pyridyl phosphorothioate] is an organophosphate insecticide widely used for agricultural and urban pest control. Trichloropyridinol (TCP; 3,5,6-trichloro-2-pyridinol), the primary metabolite of CPF, is often used as a generi...
Integrating Evidence Within and Across Evidence Streams Using Qualitative Methods (PRESENTATION)
There is high demand in environmental health for adoption of a structured process that evaluates and integrates evidence while making decisions transparent. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework holds promise to address this deman...
Systematic Review for Chemical Assessments: Core Elements and Considerations for Rapid Response (PRESENTATION)
Presentation at EPA CompTox Community of Practice on systematic review (Nov 16, 2017)
Chemical Mixtures Health Risk Assessment of Environmental Contaminants: Concepts, Methods, Applications: Handbook (PRESENTATION)
This problems-based, half-day, introductory workshop focuses on methods to assess health risks posed by exposures to chemical mixtures in the environment. Chemical mixtures health risk assessment methods continue to be developed and evolve to address concerns over health risks f...
Characterizing Risks of Exposures to Combined Stressors: An Overview (PRESENTATION)
Cumulative risk assessment (CRA) addresses the impacts of multiple chemical and nonchemical stressors on communities, resulting from complex exposures for populations with a variety of vulnerabilities. These efforts focus on real world exposure scenarios and applications that ra...
Advances in Chemical Mixtures Risk Methods (PRESENTATION)
This presentation is an overview of emerging issues for dose addition in chemical mixtures risk assessment. It is intended to give the participants a perspective of recent developments in methods for dose addition. The workshop abstract is as follows:This problems-based, half-day...
Chemical Mixtures Health Risk Assessment: Overview of Exposure Assessment, Whole Mixtures Assessments; Basic Concepts (PRESENTATION)
This problems-based, half-day, introductory workshop focuses on methods to assess health risks posed by exposures to chemical mixtures in the environment. Chemical mixtures health risk assessment methods continue to be developed and evolve to address concerns over health risks f...
EPA's Benchmark Dose Modeling Software (PRESENTATION)
The EPA developed the Benchmark Dose Software (BMDS) as a tool to help Agency risk assessors facilitate applying benchmark dose (BMD) method&rsquo;s to EPA&rsquo;s human health risk assessment (HHRA) documents. The application of BMD methods overcomes many well know limitations ...
EPA Region 10 Climate Change and TMDL Pilot – South Fork Nooksack River, Washington (PUBLISHED REPORT)
This final report provides an overarching summary of the pilot research project, including the methods used in and the findings of the quantitative and qualitative assessments. It is written to appeal to a wide audience of policy makers, managers, agency staff and the general pub...
TITLE: Twenty-five years after “Wingspread” – Environmental endocrine disruptors (EDCs) and human health: EDSP, HTS, AOPs, and TSCA (PRESENTATION)
The aim of this paper is to provide the reader with a view of the Endocrine Disruptor Chemical (EDC) research field and its relevance to human health. My perspective is from working on the effects of EDCs that act via the androgen (A) or estrogen (E) signaling pathways in a regul...