Related Topics: Health Research

Health Research Products in the Science Inventory

Records 1 to 25 of 2228

IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (Preliminary Assessment Materials) (IRIS ASSESSMENT)
In August 2013, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for RDX to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in c...
IRIS Toxicological Review of Tert-Butyl Alcohol (Tert-Butanol) (Preliminary Assessment Materials) (IRIS ASSESSMENT)
In August 2013, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for TBA to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in c...
IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE) (Interagency Science Consultation Draft) (IRIS ASSESSMENT)
In September 2016, EPA released the draft IRIS Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE) for public comment and discussion. The draft assessment was reviewed internally by EPA and by other federal agencies and White House Offices before public release. Consistent ...
Climate, Clams, and a Changing Watershed: A time series analysis to quantify the impact of management and climate on water quality in the Potomac Estuary (PRESENTATION)
The Potomac River is the largest tributary of the Chesapeake Bay and has been a key study site in water quality research, beginning with work to address public health concerns such as safe drinking water and waterborne disease during periods of population growth and urbanization ...
Remediation Options for Porous Materials Contaminated with Persistent Chemical Warfare Agents VX and HD (PUBLISHED REPORT)
Report
The Cyanobacteria Assessment Network - Recent Success in Harmful Algal Bloom Detection (NEWSLETTER ARTICLE)
Cyanobacteria blooms, which can become harmful algal blooms (HABs), are a huge environmental problem across the United States. They are capable of producing dangerous toxins that threaten the health of humans and animals, quality of drinking water supplies, and the ecosystem in w...
Suspect Screening and Non-Targeted Analysis of Drinking Water Using Point-Of-Use Filters (JOURNAL)
Monitored contaminants in drinking water represent a small portion of the total compounds present, many of which may be relevant to human health. To understand the totality of human exposure to compounds in drinking water, broader monitoring methods are imperative. In an effort t...
Evaluating a Space-Based Indicator of Surface Ozone-NOx-VOC Sensitivity Over Midlatitude Source Regions and Application to Decadal Trends (JOURNAL)
Determining effective strategies for mitigating surface ozone (O3) pollution requires knowledge of the relative ambient concentrations of its precursors, NOx, and VOCs. The space-based tropospheric column ratio of formaldehyde to NO2 (FNR) has been used as an indicator to identif...
Acute pulmonary and innate immunity health effects in mice inhaling cookstove emissions (PRESENTATION)
Background: Burning of solid-fuels in rudimentary stoves generates harmful emissions that contribute to poor indoor air quality and have detrimental impacts on human health. Acute health effects include respiratory and eye irritation, cough, acute lower respiratory infection and ...
Differential Lung Toxicity of Biomass Smoke from Smoldering and Flaming Phases Following Acute Inhalation Exposure (PRESENTATION)
We previously demonstrated that, on a mass basis, lung toxicity associated with particulate matter (PM) from flaming smoke aspirated into mouse lungs is greater than smoldering PM. This finding however has to be validated in inhalation studies to better predict real-world exposu...
Influences of serum from ozone-exposed pregnant rats in an in vitro model of implantation (PRESENTATION)
In our previous studies, ozone (O3) exposure during implantation [gestational day (GD) 5 and 6)] in rats resulted in intrauterine growth restriction (IUGR), suggesting impairment of implantation with exposure. The aim of this study was to (1) determine if serum collected from pre...
Identification of Hotspots of Genetic Risk for Type 2 Diabetes Using GIS Methods (PRESENTATION)
BACKGROUND: Having the ability to scan the entire country for potential "hotspots" with increased risk of developing chronic diseases due to various environmental, demographic, and genetic susceptibility factors may inform risk management decisions and enable better env...
Systematic Review: Land Cover, Meteorological, and Socioeconomic Determinants of Aedes Mosquito Habitat for Risk Mapping (JOURNAL)
Asian tiger and yellow fever mosquitoes (Aedes albopictus and Ae. aegypti) are global nuisances and are competent vectors for viruses such as Chikungunya (CHIKV), Dengue (DV), and Zika (ZIKV). This review aims to analyze available spatiotemporal distribution models of Aedes mosqu...
Integrating Evidence Within and Across Evidence Streams Using Qualitative Methods (PRESENTATION)
There is high demand in environmental health for adoption of a structured process that evaluates and integrates evidence while making decisions transparent. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework holds promise to address this deman...
EPA leadership on Science, Innovation, and Decision Support Tools for Addressing Current and Future Challenges (JOURNAL)
When the U.S. Environmental Protection Agency (EPA) was established nearly 50 years ago, the nation faced serious threats to its air, land, and water, which in turn impacted human health. These threats were effectively addressed by the creation of EPA (in 1970) and many subsequen...
Human Stem Cell-Derived Cardiomyocytes: An Alternative Model to Evaluate Environmental Chemical Cardiac Safety and Development of Predictive Adverse Outcome Pathways (PRESENTATION)
Biomonitoring over the last 14 years has shown human exposure to environmental chemicals has increased ~10-fold (1). In addition, mortality and morbidity related cardiovascular disease continues to be the leading national and global public health issue (2, 3). The association bet...
Validity of Self-Reported Concentration and Memory Problems: Relationship with Neuropsychological Assessment and Depression (JOURNAL)
Background: This study investigated the validity of self-reported concentration and memory problems (CMP) in residents environmentally exposed to manganese (Mn). Method: Self-report of CMP from a health questionnaire (HQ) and the Symptoms Checklist-90-Revised (SCL-90-R) was com...
The health impacts and economic value of wildland fire episodes in the U.S.: 2008-2012 (JOURNAL)
Introduction: Wildland fires degrade regional air quality and adversely affect human health. A growing body of epidemiology literature report increased rates of emergency department, hospital admission and premature deaths from wildfire smoke exposure. Objective: Our research a...
Associations of Short-Term Particle and Noise Exposures with Markers of Cardiovascular and Respiratory Health among Highway Maintenance Workers (JOURNAL)
Background: Highway maintenance workers are constantly and simultaneously exposed to traffic-related particle and noise emissions, and both have been linked to increased cardiovascular morbidity and mortality in population-based epidemiology studies. Objectives: We aimed to in...
SRC-mediated EGF Receptor Activation Regulates Ozone-induced Interleukin 8 Expression in Human Bronchial Epithelial Cells (JOURNAL)
BACKGROUND: Human exposure to ozone (03) results in pulmonary function decrements and airway inflammation. The mechanisms underlying these adverse effects remain unclear. Epidermal growth factor receptor (EGFR) plays an important role in the pathogenesis of lung inflammation. ...
Association of land use and its change with beach closure in the United States, 2004-2013 (JOURNAL)
Land use and its change have great influences on water quality. However, their impacts on microbial contamination of beach water have been rarely investigated and their relationship with beach closure is still unknown. Here, we analyzed beach closure data obtained from 2004 to 20...
Climate change impacts on projections of excess mortality at 2030 using spatially varying ozone-temperature (JOURNAL)
We project the change in ozone-related mortality burden attributable to changes in climate between a historical (1995-2005) and near-future (2025-2035) time period while incorporating a non-linear and synergistic effect of ozone and temperature on mortality. We simulate air quali...
Development and Utilization of an Ex Vivo Bromodeoxyuridine Local Lymph Node Assay (LLNA) Protocol for Assessing Potential Chemical Sensitizers (JOURNAL)
The murine local lymph node assay (LLNA) is widely used to identify chemicals that may cause allergic contact dermatitis. Exposure to a dermal sensitizer results in proliferation of local lymph node T cells, which has traditionally been measured by in vivo incorporation of [3H]m...
Lung Function Changes in Mice Sensitized to Ammonium Hexachloroplatinate (JOURNAL)
Occupational exposure to halogenated platinum salts can trigger the development of asthma. The risk to the general population that may result from the use of platinum in catalytic converters and its emerging use as a diesel fuel additive is unclear. To investigate pulmonary respo...
A Genome-wide Trans-ethnic Interaction Study Links the PIGR-FCAMR Locus to Coronary Atherosclerosis Via Interactions Between Genetic Variants and Residential Exposure to Traffic (JOURNAL)
Air pollution is a worldwide contributor to cardiovascular disease mortality and morbidity. Traffic air pollution is a ubiquitous source of air pollution in developed nations, and is associated with multiple cardiovascular outcomes such as: coronary atherosclerosis, peripheral ar...