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Abstract: We recently identified the herbicide oxyfluorfen as an inhibitor of iodide uptake by the sodium iodide symporter, a key step in thyroid hormone synthesis, using in vitro assays. We also observed a suppression of serum T4 and T3 in juvenile rats exposed orally to oxyfluo...

Climate change has increased forest fire extent in temperate and boreal North America. Here, we quantified the contribution of anthropogenic climate change to human mortality and economic burden from exposure to wildfire particulate matter at the county and state level across the...

In the US, outdoor air pollution is associated with 100,000 to 200,000 premature deaths annually. Modest increases in particulate matter (PM) are associated with increased all-cause mortality, including increased cardiovascular disease and pulmonary disease mortality, including C...

Background and Aim Ambient particulate matter (PM2.5) increases morbidity and mortality, particularly for those with underlying chronic disease. Examining disease risk factors such as blood lipids can reveal the early stages of the pathophysiologic processes triggered by PM2.5. M...

BACKGROUND AND AIM: Climate change endangers human health and well-being in numerous ways, including increases in temperature and the number of heatwaves. Increased air temperature is associated with increased age-related morbidity and mortality, but the mechanisms are ...

Background/Aim: Older individuals often have increased health risks from environmental exposures, but this has been rarely investigated using molecular measures which reflect biological age. DNA methylation is a common means to measure biological age and difference between biolog...

Background and Aim:  Prescribed burns are used for land management, but their environmental health risks have been infrequently studied.  We contrasted the health effects of prescribed burns and smoke exposure on heart failure (HF) patients in North Carolina.   Met...

BACKGROUND AND AIM: Fine particulate air pollution (PM2.5) exposure is associated with increased risk of hospital readmissions. This study aims to determine if this association differs according to the attributable source of the PM2.5. METHODS: We used zero-inflated poisson mix...

Background: As the global population ages, decreased lung function and lung disease will continue to be significant contributors to morbidity and mortality. Molecular changes associated with age have been implicated in the pathogenesis of lung disease and decreased lung function....

Background: Environmental exposures (both social and chemical) are some of the most important determinants of health and wellness. Despite decades of air quality improvements, air pollution exposure remains one of the most significant contributors to morbidity and mortality in th...

Background Heart failure (HF) is a severe form of cardiovascular disease which is increasing in prevalence. While the mortality risks from elevlated ambient fine particulate matter (PM2.5) exposure are well characaterized for HF patients, few studies have examined morbidity risks...

HiveScience is a citizen science project designed for beekeepers. This project is designed to promote EPA-public engagement around a subject regarded as profoundly important at the local, national and international levels. Following the award announcement, the project team develo...

Pollinators have been in the spotlight of ecotoxicology risk assessment since the mid-2000s with concerns for globally declining honey bee (Apis mellifera L.) populations. The current risk assessment for pollinators has utilized the honey bee as the model organism for addressing ...

This presentation, "Wildfire Advancing Science Partnerships for Indoor Reduction of Smoke Exposures (ASPIRE) Study," provides an overview of the methods, results and significance of the Wildfire ASPIRE Study components, including the 2019 web summit on clean air spaces;...

The changing intensity, and scale of wildfire is a symptom of climate change with significant smoke-related impacts on public health and downwind ecosystems.  On-going climate change will continue altering these patterns while at the same time affecting the variables that de...

As of 2015 2.1 billion people lacked access to safe drinking water and 4.5 billion lacked access to safely managed sanitation worldwide.2 An estimated 1.8 million deaths resulted from diseases related to water pollution in 2015, disproportionately affecting children under 5 years...

More than 100 metrics are developed consistently across featured communities; examples include number of residents within 300m of major roadways, percent of residents greater than 500m walking distance from a park entrance, and number of schools and day¿care centers with l...

Interventions on green space in urban settings can help address several public health issues related to obesity, cardiovascular effects, mental health and well-being. However, knowledge on the effectiveness of the interventions in relation to health, well-being and equity is part...

This report summarizes the available evidence of beneficial effects of urban green spaces, such as improved mental health, reduced cardiovascular morbidity and mortality, reduced obesity and risk of type 2 diabetes and improved pregnancy outcomes. Mechanisms leading to health ben...

Summary: Up-to-date patient resources about air pollution are now available at EPA’s AirNow.gov and Healthy Hearts websites for health care professionals. EPA’s public health resources are intended to decrease the burden of air pollution on the population and decrease...

Household air pollution is a leading risk factor for morbidity and premature mortality. Numerous cookstoves have been developed to reduce household air pollution, but it is unclear whether such cookstoves meaningfully improve health. In a controlled exposure study with a crossove...

Wildfires and the changing landscape of air pollution related health burden  Wildfires are a major sources of air pollution. Understanding emerging patterns of wildfire-related health burden, including identification of the most affected populations, is key to formulating an...

Background and Purpose:  Our goal was to evaluate ToxCastTM unique asay gene targets for biological relevancy to neurotoxicity/developmental neurotoxicity, and to compare the results to putative mechanisms of action of previously identified neurotoxicants. Methods:  A p...

SOT 2025 Conference abstract: Proteome profiling of emamectin-treated primary rat cortical cells following up to twelve days in vitro exposure W.M. Winnik, W. Padgett, D. Freeborn,  D.W. Herr, P.R.S. Kodavanti Background and Purpose: In vitro new approach methods (NAMs) have...

Inhalation is one of the three primary modes of chemical exposure, but it is particularly challenging to screen inhalable substances with in vitro methods. Air-liquid interface (ALI) exposure systems allow direct cell-toxicant interactions and can be applied for a broader variety...