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Records 1 to 25 of 7281

Peripubertal exposure to oxyfluorfen, a diphenyl herbicide, delays pubertal development in the male rat by antagonizing androgen receptor activity.
(JOURNAL) [Published : Feb 01, 2025]
Abstract: We recently identified the herbicide oxyfluorfen as an inhibitor of iodide uptake by the sodium iodide symporter, a key step in thyroid hormone synthesis, using in vitro assays. We also observed a suppression of serum T4 and T3 in juvenile rats exposed orally to oxyfluo...
Anthropogenic climate change contributes to wildfire particulate matter and related mortality in the United States
(JOURNAL) [Published : May 02, 2025]
Climate change has increased forest fire extent in temperate and boreal North America. Here, we quantified the contribution of anthropogenic climate change to human mortality and economic burden from exposure to wildfire particulate matter at the county and state level across the...
Nutrition as a modifying factor against cardiopulmonary effects of air pollution and air toxic exposure in socially advantaged and disadvantaged neighborhoods – proposed panel study
(PRESENTATION) [Presented : Mar 23, 2023]
In the US, outdoor air pollution is associated with 100,000 to 200,000 premature deaths annually. Modest increases in particulate matter (PM) are associated with increased all-cause mortality, including increased cardiovascular disease and pulmonary disease mortality, including C...
Associations between short and long-term PM2.5 exposure and blood lipid concentrations in myocardial infarction survivors
(PRESENTATION) [Presented : Sep 25, 2022]
Background and Aim Ambient particulate matter (PM2.5) increases morbidity and mortality, particularly for those with underlying chronic disease. Examining disease risk factors such as blood lipids can reveal the early stages of the pathophysiologic processes triggered by PM2.5. M...
Shortened leucocyte telomere length is associated with increased daily air temperature: KORA F3 and KORA F4
(PRESENTATION) [Presented : Sep 25, 2022]
BACKGROUND AND AIM: Climate change endangers human health and well-being in numerous ways, including increases in temperature and the number of heatwaves. Increased air temperature is associated with increased age-related morbidity and mortality, but the mechanisms are ...
Accelerated aging modifies impact of ozone on QT interval and markers of inflammation in healthy humans
(PRESENTATION) [Presented : Sep 25, 2022]
Background/Aim: Older individuals often have increased health risks from environmental exposures, but this has been rarely investigated using molecular measures which reflect biological age. DNA methylation is a common means to measure biological age and difference between biolog...
Associations between prescribed fire and smoke exposure on hospital visits and readmissions of heart failure patients
(PRESENTATION) [Presented : Sep 25, 2022]
Background and Aim:  Prescribed burns are used for land management, but their environmental health risks have been infrequently studied.  We contrasted the health effects of prescribed burns and smoke exposure on heart failure (HF) patients in North Carolina.   Met...
Source-Apportioned Particulate Air Pollution and 30-day Readmissions Among Heart Failure Patients
(PRESENTATION) [Presented : Sep 21, 2022]
BACKGROUND AND AIM: Fine particulate air pollution (PM2.5) exposure is associated with increased risk of hospital readmissions. This study aims to determine if this association differs according to the attributable source of the PM2.5. METHODS: We used zero-inflated poisson mix...
Accelerated Epigenetic Aging as a Risk Factor for Chronic Obstructive Pulmonary Disease and Decreased Lung Function in a Prospective Cohort Study
(PRESENTATION) [Presented : May 09, 2019]
Background: As the global population ages, decreased lung function and lung disease will continue to be significant contributors to morbidity and mortality. Molecular changes associated with age have been implicated in the pathogenesis of lung disease and decreased lung function....
The impacts of environmental exposures on public health outcomes
(PRESENTATION) [Presented : May 07, 2019]
Background: Environmental exposures (both social and chemical) are some of the most important determinants of health and wellness. Despite decades of air quality improvements, air pollution exposure remains one of the most significant contributors to morbidity and mortality in th...
Associations between residential exposure to fine particulate matter and days spent in hospital for heart failure patients
(PRESENTATION) [Presented : Aug 28, 2019]
Background Heart failure (HF) is a severe form of cardiovascular disease which is increasing in prevalence. While the mortality risks from elevlated ambient fine particulate matter (PM2.5) exposure are well characaterized for HF patients, few studies have examined morbidity risks...
EPA's HiveScience; A Citizen Science Project for Beekeepers
(DATA/SOFTWARE) [Published : Mar 21, 2017]
HiveScience is a citizen science project designed for beekeepers. This project is designed to promote EPA-public engagement around a subject regarded as profoundly important at the local, national and international levels. Following the award announcement, the project team develo...
Expanding Beyond the Honey Bee: Novel Approaches for Advancing Risk Assessment for Non-Apis Bees
(PAPER IN NON-EPA PROCEEDINGS) [Published : Sep 01, 2019]
Pollinators have been in the spotlight of ecotoxicology risk assessment since the mid-2000s with concerns for globally declining honey bee (Apis mellifera L.) populations. The current risk assessment for pollinators has utilized the honey bee as the model organism for addressing ...
Wildfire Advancing Science Partnerships for Indoor Reduction of Smoke Exposures (ASPIRE) Study Webinar
(PRESENTATION) [Presented : May 21, 2025]
This presentation, "Wildfire Advancing Science Partnerships for Indoor Reduction of Smoke Exposures (ASPIRE) Study," provides an overview of the methods, results and significance of the Wildfire ASPIRE Study components, including the 2019 web summit on clean air spaces;...
Changing Climate and the Toxicity of Wildfire-derived Brown Carbon Particles: A Literature Synthesis and Science Assessment for Evaluating Potential Human Health Impacts
(PRESENTATION) [Presented : Oct 02, 2023]
The changing intensity, and scale of wildfire is a symptom of climate change with significant smoke-related impacts on public health and downwind ecosystems.  On-going climate change will continue altering these patterns while at the same time affecting the variables that de...
Water Pollution
(BOOK CHAPTER) [Published : Jan 01, 2021]
As of 2015 2.1 billion people lacked access to safe drinking water and 4.5 billion lacked access to safely managed sanitation worldwide.2 An estimated 1.8 million deaths resulted from diseases related to water pollution in 2015, disproportionately affecting children under 5 years...
Indicators for all EnviroAtlas communities with a minimum of 6 communities delivered per year-Template
(DATA/SOFTWARE) [Published : Sep 30, 2016]
More than 100 metrics are developed consistently across featured communities; examples include number of residents within 300m of major roadways, percent of residents greater than 500m walking distance from a park entrance, and number of schools and day¿care centers with l...
Urban Green Space Interventions and Health: a Review of Impacts and Effectiveness
(PUBLISHED REPORT) [Published : Oct 01, 2017]
Interventions on green space in urban settings can help address several public health issues related to obesity, cardiovascular effects, mental health and well-being. However, knowledge on the effectiveness of the interventions in relation to health, well-being and equity is part...
Urban Green Spaces and Health
(PUBLISHED REPORT) [Published : Oct 01, 2016]
This report summarizes the available evidence of beneficial effects of urban green spaces, such as improved mental health, reduced cardiovascular morbidity and mortality, reduced obesity and risk of type 2 diabetes and improved pregnancy outcomes. Mechanisms leading to health ben...
Healthier Environments Make Healthier Hearts
(NEWSLETTER ARTICLE) [Published : Mar 28, 2017]
Summary: Up-to-date patient resources about air pollution are now available at EPA’s AirNow.gov and Healthy Hearts websites for health care professionals. EPA’s public health resources are intended to decrease the burden of air pollution on the population and decrease...
Acute Differences in Blood Lipids and Inflammatory Biomarkers Following Controlled Exposures to Cookstove Air Pollution in the STOVES Study
(JOURNAL) [Published : Jul 02, 2020]
Household air pollution is a leading risk factor for morbidity and premature mortality. Numerous cookstoves have been developed to reduce household air pollution, but it is unclear whether such cookstoves meaningfully improve health. In a controlled exposure study with a crossove...
Public Health Impact of Fine Particulate Matter (PM2.5) from Prescribed and Wildland Fires in California
(PRESENTATION) [Presented : Mar 23, 2025]
Wildfires and the changing landscape of air pollution related health burden  Wildfires are a major sources of air pollution. Understanding emerging patterns of wildfire-related health burden, including identification of the most affected populations, is key to formulating an...
Identification of Toxcast Intended Gene Targets Relevant to Neurotoxicity/Developmental Neurotoxicity and Putative Mechanisms of Neurotoxicity.
(PRESENTATION) [Presented : Mar 17, 2025]
Background and Purpose:  Our goal was to evaluate ToxCastTM unique asay gene targets for biological relevancy to neurotoxicity/developmental neurotoxicity, and to compare the results to putative mechanisms of action of previously identified neurotoxicants. Methods:  A p...
Proteome profiling of emamectin-treated primary rat cortical cells following up to twelve days in vitro exposure
(PRESENTATION) [Presented : Mar 18, 2025]
SOT 2025 Conference abstract: Proteome profiling of emamectin-treated primary rat cortical cells following up to twelve days in vitro exposure W.M. Winnik, W. Padgett, D. Freeborn,  D.W. Herr, P.R.S. Kodavanti Background and Purpose: In vitro new approach methods (NAMs) have...
Advancing In Vitro Dosimetry Methods and Reporting Standards for Air-Liquid Interface Exposures
(PRESENTATION) [Presented : Mar 18, 2025]
Inhalation is one of the three primary modes of chemical exposure, but it is particularly challenging to screen inhalable substances with in vitro methods. Air-liquid interface (ALI) exposure systems allow direct cell-toxicant interactions and can be applied for a broader variety...