Related Topics: Health Research

Health Research Products in the Science Inventory

Records 1 to 25 of 2191

PUBLIC COMMENT ON THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2018 FEDERAL PHYSICAL ACITIVTY GUIDELINES (PRESENTATION)
Title: Public Comment on Department of Health and Human Services (DHHS) 2018 Physical Activity Guidelines Author: Wayne E. Cascio, Director, Environmental Public Health Division, US EPA Abstract: In the 2008 Physical Activity Guidelines, the effects of air pollution and advers...
Measuring the Bioenergetic Effects of 1,2-Naphthoquinone Exposure on Human Lung Macrophages Using Seahorse Extracellular Flux Analyses (PRESENTATION)
Exposure to ambient particulate matter (PM) is one of the leading causes of morbidity and mortality in humans. Quinones are organic PM components that induce inflammatory responses through redox cycling and electrophilic attack. 1,2-naphthoquinone (1,2-NQ) has previously been sho...
THE INFLUENCE OF SOURCE AND CHEMISTRY ON THE TOXICITY OF AMBIENT PARTICULATE MATTER (PRESENTATION)
Air pollution has long been associated with detrimental health risks in susceptible populations. Experimental evidence in rodents indicates that inhaled or instilled particles from heavy industry, diesel exhaust particles, woodsmoke or collected from different locations can caus...
Studies on the Deposition, Clearance and Toxicity of Combustion Emissions (PRESENTATION)
Seminar on the health impacts of diesel exhaust and biomass combustion emissions
Hospital visits for gastrointestinal Illness after a major water main break in 2010 (PRESENTATION)
Background/Aim Water main breaks can occur due to the stresses of an aging infrastructure and changing climate. Water main breaks are a public health concern because they can cause pressure transients (specifically, abrupt decreases in water pressure/flow in the pipeline), which ...
To Each Their Own: Molecular Mechanisms of Inter-Individual Variability in Toxic Exposure Effects (PRESENTATION)
Traditional approaches to identifying susceptible populations have relied on factors such as age, genotype, and disease status to explain variability in exposure outcomes; however, these are neither sufficient to faithfully identify differentially responsive individuals nor are t...
Adrenergic and steroid hormone modulation of ozone-induced pulmonary injury and inflammation (PRESENTATION)
Rationale: We have shown that acute ozone inhalation promotes activation of the sympathetic and hypothalamic-pituitary-adrenal (HPA) axis leading to release of cortisol and epinephrine from the adrenals. Adrenalectomy (ADREX) inhibits ozone-induced pulmonary vascular leakage and ...
Sex Differences in Placental Mitochondrial Function Associated with Ozone-Induced Fetal Growth Restriction (PRESENTATION)
Fetal growth restriction is a major underlying cause of infant mortality worldwide. Despite knowledge of risk factors for adverse pregnancy outcomes, the mechanisms that drive compromised growth during pregnancy have not been well established. Placental maladaptation, particularl...
Prediction of Skin Sensitization Potency Using Machine Learning Approaches (PRESENTATION)
Replacing animal tests currently used for regulatory hazard classification of skin sensitizers is one of ICCVAM’s top priorities. Accordingly, U.S. federal agency scientists are developing and evaluating computational approaches to classify substances as sensitizers or nons...
Use of large electronic health record databases for environmental epidemiology studies. (PRESENTATION)
Background: Electronic health records (EHRs) are a ubiquitous component of the United States healthcare system and capture nearly all data collected in a clinic or hospital setting. EHR databases are attractive for secondary data analysis as they may contain detailed clinical rec...
Smoke Sense – a crowd sourced study of health impacts of wildland fire smoke exposures## (PRESENTATION)
Exposure to particles and gasses found in wildfire smoke are linked to a range of health outcomes, affecting wellbeing and productivity in the affected communities. The impacts of the most severe outcomes are well documented in scientific literature; but less is known about the h...
Basal gene expression predicts ozone-induced pro-inflammatory response in GSTM1-null individuals (PRESENTATION)
Air pollution exposure causes increased cardiopulmonary morbidity and mortality and has been linked to the deaths of 7 million people every year by the World Health Organization. Approximately 40% of the population lack expression of the antioxidant enzyme glutathione S-transfer...
Wildfire smoke exposure and cardiopulmonary hospitalizations among those over age 65 in the United States (PRESENTATION)
Background: The health implications of excess PM2.5 due to wildland fire smoke are not well understood. Very few studies have assessed the effect of wildland fire smoke from multiple fires across the US. Methods: We estimated daily concentrations of PM2.5 due to wildland fire smo...
Smoke Sense – a crowd sourced study of health impacts of wildland fire smoke exposures (PRESENTATION)
Exposure to particles and gasses found in wildfire smoke are linked to a range of health outcomes, affecting wellbeing and productivity in the affected communities. The impacts of the most severe outcomes are well documented in scientific literature; but less is known about the h...
Environmental quality modifies the relationship between county-level leisure-time physical inactivity and obesity in the U.S. (PRESENTATION)
Background/Aim More than one-third of U.S. adults are obese, making them vulnerable to multiple poor outcomes including diabetes, heart disease, cancer, and death. Physical inactivity is a well-established mechanism contributing to obesity that can be promoted or hindered by nume...
Dietary Intervention to Mitigate the Health Effects of PM Exposure in Humans (PRESENTATION)
Exposure to ambient air pollution is a major cause of global morbidity and mortality. This presentation will highlight previously published, ongoing and planned studies conducted at the Human Studies Facility that have examined the efficacy of nutritional supplementation in modul...
Redox Toxicology of Ambient Air Pollution (PRESENTATION)
Ambient air pollution is a leading global cause of morbidity and mortality. Millions of Americans live in areas in which levels of tropospheric ozone exceed air quality standards, while exposure to particulate matter (PM2.5) alone results in 3.2 million excess deaths annually wor...
Association between environmental quality and lung cancer survival in the United States, 2000-2005. (PRESENTATION)
Background/Aims Lung cancer remains one of the most prevalent and lethal cancers in the United States. Individual environmental exposures have been associated with lung cancer incidence. However, the impact of cumulative environmental exposures on survival is not well understood ...
A conditional Poisson analysis of fine particulate matter and U.S. Medicare hospitalization, 1999-2010, by individual-level chronic health conditions. (PRESENTATION)
Background/Aim: A previous analysis suggested that U.S. counties with higher county-level prevalence of chronic conditions had stronger associations of mortality with fine particulate matter (PM2.5). This study assesses the modification of the effect of PM2.5 on daily hospitaliz...
Environmental Public Health Research at the U.S. Environmental Protection Agency – Addressing Community Exposures and Outcomes from One Researcher’s Perspective (PRESENTATION)
The U.S. Environmental Protection Agency’s (U.S. EPA) mission is to protect human health and the environment. Those not familiar with U.S. EPA’s mission often do not realize that U.S. EPA is a public health agency. In this presentation, Dr. Danelle Lobdell will provid...
Population (BOOK CHAPTER)
Population growth influences many stressors on Narragansett Bay and its Watershed, including all landscape and chemical stressors discussed in other chapters of this report. In numerous ways, population growth affects the condition of the Bay ecosystem, Watershed ecosystem, and h...
SVOC emissions from diesel trucks operating of biodiesel fuels (PRESENTATION)
The U.S. currently produces roughly 5 billion liters of biodiesel per year. Use of biodiesel is projected to increase based on its potential economic, energy, and environmental benefits. Despite these benefits, there is public health concern about the possible direct and indirect...
A Cellular Game of Telephone: Trans Tissue Reprogramming of Responses to Toxic Stimuli (PRESENTATION)
Exposure to air pollution is a leading cause of cardiopulmonary morbidity and mortality; however, while these effects outside the lung have been associated with aberrant oxidative stress and inflammation, the underlying molecular mechanisms are poorly understood. We hypothesized ...
Rubbertown NGEM Demonstration Project - Community Meeting 3 (PRESENTATION)
Rubbertown Next Generation Emission Measurement Demonstration: Background: ...
Dollars and Deadlines: Rule Reforms in Short Time Frames (JOURNAL)
ABSTRACT: In "At Last! Aye, and there's the Rub" (i.e., the target article for this commentary), Capron describes challenges related to the timing for development, adoption, and revision of the Common Rule. Specifically, what the National Commission thought would be a...