Related Topics: Health Research

Health Research Products in the Science Inventory

Records 1 to 25 of 4201

The Cyanobacteria Assessment Network - Recent Success in Harmful Algal Bloom Detection (NEWSLETTER ARTICLE)
Cyanobacteria blooms, which can become harmful algal blooms (HABs), are a huge environmental problem across the United States. They are capable of producing dangerous toxins that threaten the health of humans and animals, quality of drinking water supplies, and the ecosystem in w...
Suspect Screening and Non-Targeted Analysis of Drinking Water Using Point-Of-Use Filters (JOURNAL)
Monitored contaminants in drinking water represent a small portion of the total compounds present, many of which may be relevant to human health. To understand the totality of human exposure to compounds in drinking water, broader monitoring methods are imperative. In an effort t...
Incorporating a Socio-Ecological-Technological Systems (SETS) perspective into the adaptive management framework (PRESENTATION)
Incorporating a social-ecological-technological systems (SETS) perspective to the adaptive management process requires that stakeholders and managers conceptualize restoration projects as part of coupled human and natural systems and assess underlying social drivers and accrued b...
Computational embryology as an integrative platform for predictive DART (45th Conf of Europ Teratology Society) (PRESENTATION)
Chemical regulation is challenged by the large number of chemicals requiring assessment for potential human health and environmental impacts. For example, the USEPA lists more than 85,000 chemicals on its inventory of substances that fall under the Toxic Substances Control Act (T...
EPA and EFSA approaches for Benchmark Dose modeling (PRESENTATION)
Benchmark dose (BMD) modeling has become the preferred approach in the analysis of toxicological dose-response data for the purpose of deriving human health toxicity values. The software packages most often used are Benchmark Dose Software (BMDS, developed by EPA) and PROAST (de...
Acute pulmonary and innate immunity health effects in mice inhaling cookstove emissions (PRESENTATION)
Background: Burning of solid-fuels in rudimentary stoves generates harmful emissions that contribute to poor indoor air quality and have detrimental impacts on human health. Acute health effects include respiratory and eye irritation, cough, acute lower respiratory infection and ...
Toxicity Testing in the 21st Century EPA’s CompTox Approach (TAMU CVM lecture)EPA’s CompTox Approach (TAMU CVM) (PRESENTATION)
Lecture presentation at the Texas A&M U CVM session on Practice of Evaluating Human Health Risks of Chemicals
Wading through Perceptions: Understanding Human Perceptions of Water Quality in Coastal Waters (PRESENTATION)
Water quality perceptions influence people’s preferences for visiting coastal areas and willingness to participate in activities on or near the water. They also influence people’s social values for a waterbody, sense of place, support for protection of a waterbody, an...
Identification of Hotspots of Genetic Risk for Type 2 Diabetes Using GIS Methods (PRESENTATION)
BACKGROUND: Having the ability to scan the entire country for potential "hotspots" with increased risk of developing chronic diseases due to various environmental, demographic, and genetic susceptibility factors may inform risk management decisions and enable better env...
Systematic Review: Concept and Tool Development with Application in the Integrated Risk Information System (IRIS) Assessment Process (PRESENTATION)
Systematic Review: Concept and tool development with application to the National Toxicology Program (NTP) and the Integrated Risk Information System (IRIS) Assessment Processes. There is growing interest within the environmental health community to incorporate systematic review m...
Effects of chlorpyrifos and trichloropyridinol on HEK 293 human embryonic kidney cells (JOURNAL)
Chlorpyrifos (CPF) [O, O-diethyl -O-3, 5, 6-trichloro-2-pyridyl phosphorothioate] is an organophosphate insecticide widely used for agricultural and urban pest control. Trichloropyridinol (TCP; 3,5,6-trichloro-2-pyridinol), the primary metabolite of CPF, is often used as a generi...
Integrating Evidence Within and Across Evidence Streams Using Qualitative Methods (PRESENTATION)
There is high demand in environmental health for adoption of a structured process that evaluates and integrates evidence while making decisions transparent. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework holds promise to address this deman...
EPA leadership on Science, Innovation, and Decision Support Tools for Addressing Current and Future Challenges (JOURNAL)
When the U.S. Environmental Protection Agency (EPA) was established nearly 50 years ago, the nation faced serious threats to its air, land, and water, which in turn impacted human health. These threats were effectively addressed by the creation of EPA (in 1970) and many subsequen...
Systematic Review for Chemical Assessments: Core Elements and Considerations for Rapid Response (PRESENTATION)
Presentation at EPA CompTox Community of Practice on systematic review (Nov 16, 2017)
Chemical Mixtures Health Risk Assessment of Environmental Contaminants: Concepts, Methods, Applications: Handbook (PRESENTATION)
This problems-based, half-day, introductory workshop focuses on methods to assess health risks posed by exposures to chemical mixtures in the environment. Chemical mixtures health risk assessment methods continue to be developed and evolve to address concerns over health risks f...
Characterizing Risks of Exposures to Combined Stressors: An Overview (PRESENTATION)
Cumulative risk assessment (CRA) addresses the impacts of multiple chemical and nonchemical stressors on communities, resulting from complex exposures for populations with a variety of vulnerabilities. These efforts focus on real world exposure scenarios and applications that ra...
Chemical Mixtures Health Risk Assessment: Overview of Exposure Assessment, Whole Mixtures Assessments; Basic Concepts (PRESENTATION)
This problems-based, half-day, introductory workshop focuses on methods to assess health risks posed by exposures to chemical mixtures in the environment. Chemical mixtures health risk assessment methods continue to be developed and evolve to address concerns over health risks f...
EPA's Benchmark Dose Modeling Software (PRESENTATION)
The EPA developed the Benchmark Dose Software (BMDS) as a tool to help Agency risk assessors facilitate applying benchmark dose (BMD) method’s to EPA’s human health risk assessment (HHRA) documents. The application of BMD methods overcomes many well know limitations ...
Applying ecological function in environmental decision making (PRESENTATION)
The Final ecosystem goods and services (FEGS) concept has become increasingly valuable for identifying and evaluating important trade-offs in estuarine management, yet the translation of FEGS science into policy is limited by a need for meaningful reference points. A research pr...
TITLE: Twenty-five years after “Wingspread” – Environmental endocrine disruptors (EDCs) and human health: EDSP, HTS, AOPs, and TSCA (PRESENTATION)
The aim of this paper is to provide the reader with a view of the Endocrine Disruptor Chemical (EDC) research field and its relevance to human health. My perspective is from working on the effects of EDCs that act via the androgen (A) or estrogen (E) signaling pathways in a regul...
Quantification of the uncertainties in extrapolating from in vitro androgen receptor (AR) antagonism to key events in in vivo screening assays and adverse reproductive outcomes in F1 male rats (PRESENTATION)
There are multiple molecular initiating events (MIEs) that can disrupt male sexual differentiation including AR antagonism and inhibition of synthesis, and metabolism of fetal testosterone. Disruption of this event by pesticides like vinclozolin that act as AR antagonists and ph...
Twenty-five years after "Wingspread"- Environmental endocrine disruptors (EDCs) and human health (JOURNAL)
The development of life-stage and tissue-specific AOPs for EDCs can reduce the uncertainty in extrapolating of the effects of EDCs from in vitro and in vivo studies in laboratory animals to humans. When the key events (KEs) and molecular initiating event (MIEs) in a pathway are...
The health impacts and economic value of wildland fire episodes in the U.S.: 2008-2012 (JOURNAL)
Introduction: Wildland fires degrade regional air quality and adversely affect human health. A growing body of epidemiology literature report increased rates of emergency department, hospital admission and premature deaths from wildfire smoke exposure. Objective: Our research a...
PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling (JOURNAL)
Perfluoroalkyl acids (PFAAs) are ubiquitous and persistent environmental contaminants. Compounds such as perfluoroocanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonate (PFHxS) are readily found in the tissues of humans...
In vitro screening of silver nanoparticles and ionic silver using neural networks yields differential effects on spontaneous activity and pharmacological responses. (JOURNAL)
Silver nanoparticles (AgNPs) are used in a wide range of consumer and medical products because of their antimicrobial and antifungal properties. Numerous studies have demonstrated that silver can translocate to distal organs following exposure to AgNPs. Therefore, it is essential...