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Abstract: Despite the number of in vitro assays that have been recently developed to identify chemicals that interfere with the hypothalamic-pituitary-thyroid axis (HPT), the translation of those in vitro results into in vivo responses (in vitro to in vivo extrapolation, IVIVE) ...

The 2007 NAS report on Toxicity Testing for the 21st Century was a watershed moment for toxicology. Since then, the discussion is no longer whether to change but how and how fast? With knowledge in the life sciences doubling every seven years, we now have four times more understa...

We describe the development and implementation of a Physiological and Anatomical Visual Analytics tool (PAVA), a web browser-based application, used to visualize experimental/simulated chemical time-course data (dosimetry), epidemiological data and Physiologically-Annotated Data ...

Subsurface contamination can migrate upward into overlying buildings, exposing the buildings’ inhabitants to contaminants that can cause detrimental health effects. This phenomenon is known as vapor intrusion (VI). When evaluating a building for VI, understand that seasonal...

The EPA flooded homes website is intended to help homeowners, renters, and volunteers safely muck out, clean up, and fix up homes that have been affected by flooding. This presentation describes the research used to develop the website as a risk communication tool. The research p...

Manual provides guidance on the selection, design, and operation of membrane filtration to comply with the treatment requirements of the Long Term 2 Enhanced Surface Water Treatment Rule (LT2 ESWTR).

Antimicrobial (AMR) research at the EPA has resulted in the publication of  3 new journal articles since Sept. 2024 when this dynamic graphic summary that was last updated.  Major points from these papers include: 1. Microplastic surfaces encourage biofilm formation, enriching a...

Wastewater-based testing (WBT) and surveillance research at a fine-spatial scale holds significant potential for monitoring and epidemiology, sewer fate and transport studies, antimicrobial resistance research, and benefiting wastewater utilities (e.g., identifying illicit discha...

 Background and Purpose Disinfection byproducts (DBPs) are chemical compounds that form when disinfectants like chlorine, chloramine, or ozone react with organic and inorganic materials present in water. While disinfection is critical for protecting public health by eliminat...

The ECOTOXicology Knowledgebase (ECOTOX) is a comprehensive, publicly available resource providing single chemical environmental toxicity data on aquatic life, terrestrial plants and wildlife.The database is updated quarterly, and to identify relevant references and extract perti...

Regulatory decisions surrounding chemical safety are based primarily, although not exclusively, on human and environmental protection. Historically, there has been a reliance on animal toxicity testing to inform hazard and risk assessment. Typically, mammalian data drive human he...

Identifying chemical stressors present in various environments is necessary to evaluate potential exposures and their subsequent health risks. Targeted analysis has been the traditional method for chemical monitoring; however, emergent chemicals and their transformation products ...

Each year, as the sheer amount of chemicals readily available to the market increases, so does the need for short-term and cost effective high-throughput assays that can be used to evaluate chemical potency and infer potential hazards to human health and/or ecosystems. Over the p...

6PPD-quinone (N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone), a transformation product of the antiozonant 6PPD (N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine) is a likely causative agent of coho salmon (Oncorhynchus kisutch) pre-spawn mortality. Stormwater runof...

Presentation to the US EPA OHHRRAF Webinar, May 2025

Wetlands provide many ecosystem services, such as mitigating pollution, attenuating flooding and drought extremes, and providing habitat for many species. However, studies quantifying potential wetland sequestration of heavy metals as an ecosystem service, particularly across lar...

The Great Lakes Water Quality Agreement (GLWQA) identifies degradation of aesthetics as one of the beneficial uses of the ecosystem that should be restored. Degraded aesthetics, such as odors and debris, can leave a negative impact on the local community through decreased recreat...

COVID-19 is a zoonotic disease caused by infection of the coronavirus SARS-CoV-2. SARS-CoV-2 has been demonstrated to pass from animals to humans and from humans to animals; infections have been detected in animals in North America including minks, ferrets, white-tailed deer, big...

Cesium-137 (Cs-137) is a persistent contaminant that poses a significant risk to human health and the environment. Understanding the fate and transport of Cs-137 following a contamination incident is necessary for effective containment and remediation. In this study, we performed...

Risk assessment plays a unique role in serving the needs of various regulatory programs through incorporating, integrating, and coordinating the use of scientific information as a foundation for regulatory decision-making. The Risk Assessment Training and Experience (RATE) Progra...

Wasted food is a major global environmental, social, and economic challenge. Recognizing the critical importance of reducing food loss and waste, in September 2015, the EPA and U.S. Department of Agriculture (USDA) announced the U.S. 2030 Food Loss and Waste Reduction Goal, which...

Risk assessment plays a unique role in serving the needs of various regulatory programs through incorporating, integrating, and coordinating the use of scientific information as a foundation for regulatory decision-making. The Risk Assessment Training and Experience (RATE) Progra...

This chapter describes the development of a decision support tool, the Priority Response Environmental Screening Tool (PRESTO), designed to assist the U.S. Environmental Protection Agency (EPA), in partnership with state and local decision-makers, in prioritizing locations for in...

Emphasis has widely been placed on utilizing New Approach Methods (NAMs) and predictive approaches in chemical toxicity evaluations to conserve resources, generate data faster, and reduce the use of animals. Advancements in bioinformatics have led to the development of in silico ...

Wetlands are known to provide a myriad of vital ecosystem functions and services, which may be under threat from a changing climate. However, climate change effects may not be homogenous across ecosystem functions, wetland types, or ecoregions. Therefore, it may not be appropriat...