This problems-based, half-day, introductory workshop focuses on methods to assess health risks posed by exposures to chemical mixtures in the environment. Chemical mixtures health risk assessment methods continue to be developed and evolve to address concerns over health risks f...

Cumulative risk assessment (CRA) addresses the impacts of multiple chemical and nonchemical stressors on communities, resulting from complex exposures for populations with a variety of vulnerabilities. These efforts focus on real world exposure scenarios and applications that ra...

The coupled WRF-CMAQ modeling system is a combined meteorology-chemistry model designed to simulate the emission, transport and chemistry of atmospheric pollutants, while also allowing for direct aerosol radiative feedback between the meteorological model (WRF) and the chemical t...

The drinking water and wastewater cycles are integrally linked. Chemicals that are present in household wastewater may be sufficiently mobile and recalcitrant to pass through on-site or municipal wastewater treatment and survive natural environmental removal processes. Such per...

In order to reduce reliance on resource-intensive animal toxicity testing that supports human and ecological health risk assessment, public health agencies are relying more on alternative test methods and strategies to assess risks of injury to health that arise from exposures to...

Non-invasive or minimally invasive near surface geophysics can yield three-dimensional maps of subsurface physical properties and aid high resolution site characterization. This presentation will demonstrate the application of geophysical methods for various site objectives such...

Smart new strategies to design, produce, and use safer chemicals to minimize risks and prevent pollution are a priority for the U.S. Environmental Protection Agency (EPA). EPA is developing a comprehensive approach to enhance the Agency’s management of existing chemicals and emer...

Scientists and managers from government, academia, NGOs and the private sector came together in June 2014 to review the science and management related to reactive nitrogen and co-pollutants (e.g., phosphorus, sulfur) across the U.S. Department of Agriculture (USDA), U.S. Geologic...

Prioritizing the potential risk posed to human health by the thousands of chemicals that occur in commerce and the environment requires tools that can estimate exposure from limited information. High-throughput exposure (HTE) models exist to predict exposure via specific pathways...

International concern about contaminated sediments is increasing as sustainable practices are needed to maintain water resources and waterways as important economic, commercial, recreational, and community resources. Sediments often serve as long-term sinks for legacy pollutants,...

This presentation gives an overview of how high-throughput toxicology can be used to develop tools that can have regulatory use. First, ToxCast, the toxcast data pipeline, and uncertainties are reviewed. Then, recent successes in building fit-for-purpose tools for Endocrine Disru...

Surface water bodies adjacent to sites with contaminated groundwater may receive impacts that impair otherwise functional ecosystems and create new exposure pathways, increasing human health risks. Optimizing site characterization protocols to improve the remedy design effort is...

Atmospheric models that accurately describe the fate and transport of trace species for the right reasons aid in the development of effective air-quality management strategies that safeguard human health. Controllable emissions facilitate the formation of biogenic secondary organ...

We assessed the annual probability of infection resulting from non-potable exposures to distributed greywater and domestic wastewater treated by an aerobic membrane bioreactor (MBR) followed by chlorination. A probabilistic quantitative microbial risk assessment was conducted for...

Most human biomonitoring efforts to date have been limited to bioaccumulative chemicals with known or likely human health impacts. High throughput exposure models currently rely upon these data alone for evaluation. The evolution of high resolution mass spectrometry affords the o...

Human health risk assessment associated with environmental chemical exposure is limited by the tens of thousands of chemicals with little or no experimental in vivo toxicity data. Data gap filling techniques, such as quantitative structure activity relationship (QSAR) models base...

The 2017 report by the National Academy of Sciences “Using 21st Century Science to Improve Risk-Related Evaluations” found that a major obstacle to estimating any risks posed to human health by chemicals was uncertainty in source information, including consumer product compositio...

The EPA has begun to identify and define methodologies for developing maps and mapping tools that allow for an assessment of the health impacts of extreme heat on vulnerable populations. Maps can serve as powerful tools for analysis and communication. They reveal complex spatial ...

EPA has finalized the Integrated Risk Information System (IRIS) assessment of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX). This assessment addresses the potential cancer and noncancer human health effects from exposure to RDX. Now final, this assessment updates the toxicologica...

EPA is developing an Integrated Risk Information System (IRIS) assessment of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and has released the draft assessment for public comment. When final, the assessment will appear on the IRIS database.

On March 10, 2016, the public comment draft Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine and the draft charge to external peer reviewers were released for public review and comment. The Toxicological Review and charge were reviewed internally by EPA and by othe...

In August 2013, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for RDX to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in c...

Report—Exposure estimates were performed to rank the various livestock carcass management options relative to one another for a hypothetical site and mortality scenario from a potential biological incident. Assessment included an ordinal scale ranking (ranking of individual condi...

An alternatives assessment facilitates a comparison of potential alternatives to a chemical of concern. Alternatives assessment should include life-cycle considerations to account for releases and exposures that occur during the extraction, manufacturing, use, and disposal phases...

The webinar Power Point slides will introduce the goals of the new EPA STAR RFA, provide basic and general information about the research areas and questions, application eligibility information, submission information, and review information. It will also provide the EPA NCER co...