Related Topics: Health Research

Health Research Products in the Science Inventory

Records 1 to 25 of 4215

Overview of the Inhalation Carcinogenicity of Ethylene Oxide (EtO) (PRESENTATION)
The presentation will cover the following topics as they relate to the ethylene oxide IRIS assessment: ...
20170313 - CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity (SOT) (PRESENTATION)
In order to protect human health from chemicals that can mimic natural hormones, the U. S. Congress mandated the U.S. EPA to screen chemicals for their potential to be endocrine disruptors through the Endocrine Disruptor Screening Program (EDSP). However, the number of chemicals ...
20170312 - Modeling Zebrafish Developmental Toxicity using a Concurrent In vitro Assay Battery (SOT) (PRESENTATION)
We describe the development of computational models that predict activity in a repeat-dose zebrafish embryo developmental toxicity assay using a combination of physico-chemical parameters and in vitro (human) assay measurements. The data set covered 986 chemicals including pestic...
Human health effects and remotely sensed cyanobacteria (PRESENTATION)
Cyanobacteria blooms (HAB) pose a potential health risk to beachgoers, including HAB-associated gastrointestinal, respiratory and dermal illness. We conducted a prospective study of beachgoers at a Great Lakes beach during July – September, 2003. We recorded each participan...
Background Contamination by Coplanar Polychlorinated Biphenyls (PCBS) in Trace Level High Resolution Gas Chromatography/High Resolution Mass Spectrometry (HRGC/HRMS) Analytical Procedures (JOURNAL)
The addition of the "dioxin-like" polychlorinated biphenyl (PCB) congeners to the assessment of risk associated with the 2,3,7,8-chlorine substituted dioxins and furans has dramatically increased the number of laboratories worldwide that are developing analytical procedures for t...
Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages (JOURNAL)
Predicting age-specific metabolism is important for evaluating age-related drug and chemical sensitivity. Multiple cytochrome P450s and carboxylesterase enzymes are responsible for human pyrethroid metabolism. Complete ontogeny data for each enzyme are needed to support in vitro ...
Ecdysone receptor agonism leading to lethal molting disruption in arthropods: Review and adverse outcome pathway development (JOURNAL)
Molting is a key biological process in growth, development, reproduction and survival in arthropods. Complex neuroendocrine pathways are involved in the regulation of molting and may potentially become targets of environmental endocrine disrupting compounds (EDCs). For example, s...
Evaluation of the scientific underpinnings for identifying estrogenic chemicals in non-mammalian taxa using mammalian test systems (JOURNAL)
A major challenge in chemical risk assessment is extrapolation of toxicity data from tested to untested species. Successful cross-species extrapolation involves understanding similarities and differences in toxicokinetic and toxicodynamic processes among species. Herein we consi...
Organohalogen Pollutants and Human Health (BOOK CHAPTER)
During the past century, a vast number of organic chemicals have been manufactured and used in industrial, agricultural, public health, consumer products and other applications. Widespread use of organohalogens, including chlorinated, brominated and fluorinated compounds, lead to...
EPA's evaluation of the carcinogenic potential of glyphosate (ASSESSMENT DOCUMENT)
Recently, several international agencies have evaluated the carcinogenic potential of glyphosate. In March 2015, the International Agency for Research on Cancer (IARC), a subdivision of the World Health Organization (WHO), determined that glyphosate was a probable carcinogen (gro...
Exhaled breath aerosol (EBA): the simplest non-invasive medium for public health and occupational exposure biomonitoring (JOURNAL)
Blood, breath and urine represent the three primary diagnostic fluids for assessing environmental exposures and human health state. Although there is overlap in biological media choice for many applications, each have their individual strategic and analytical advantages: Blood is...
Provisional Peer-Reviewed Toxicity Values for Dichlorodiphenyldichloroethane, P,p'- (2007 final Report) (ASSESSMENT DOCUMENT)
This is the final Provisional Peer-Review Toxicity Value report generated for EPA's Superfund Program.
Titanium Dioxide-Based Antibacterial Surfaces for Water Treatment (JOURNAL)
The field of water disinfection is gaining much interest since waterborne diseases caused by pathogenic microorganisms directly endanger human health. Antibacterial surfaces offer a new, ecofriendly technique to reduce the harmful disinfection byproducts that form in medical and ...
Proposed key characteristics of male reproductive toxicants as a method for organizing and screening mechanistic evidence for non-cancer outcomes. (PRESENTATION)
The adoption of systematic review practices for risk assessment includes integration of evidence obtained from experimental, epidemiological, and mechanistic studies. Although mechanistic evidence plays an important role in mode of action analysis, the process of sorting and anal...
Chapter 8. Ecotoxicological effects and risk assessment of pollutants (BOOK CHAPTER)
Until somewhat recently there was limited awareness about the impact of soils on human health, ecosystems, and economy. Only in the second half of the twenty century the world awaked for the poor condition of soils, and to its several threats (e.g. soil contamination), as well as...
Evaluating the Similarity of Complex Drinking-Water Disinfection By-Product Mixtures: Overview of the Issues (PRESENTATION)
The Presentation describes the advantages and challenges of working with Whole Mixtures, discusses an exploratory approach for evaluating sufficient similarity, and challenges of applying such approaches to other environmental mixtures.
An analysis of cumulative risks based on biomonitoring data for six phthalates using the Maximum Cumulative Ratio (JOURNAL)
The Maximum Cumulative Ratio (MCR) quantifies the degree to which a single chemical drives the cumulative risk of an individual exposed to multiple chemicals. Phthalates are a class of chemicals with ubiquitous exposures in the general population that have the potential to cause ...
The Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) frameworks facilitate the integration of human health and ecological endpoints for Cumulative Risk Assessment (CRA) (JOURNAL)
Cumulative risk assessment (CRA) methods promote the use of a conceptual site model (CSM) to apportion exposures and integrate risk from multiple stressors. While CSMs may encompass multiple species, evaluating end points across taxa can be challenging due to data availability an...
The PPARα-dependent rodent liver tumor response is not relevant to humans: Addressing misconceptions (JOURNAL)
A number of industrial chemicals and therapeutic agents cause liver tumors in rats and mice by activating the nuclear receptor peroxisome proliferator-activated receptor α (PPARα). The molecular and cellular events by which PPARα activators induce rodent hepatoc...
Eco-Health Linkages: Assessing the Role of Ecosystem Goods and Services on Human Health Using Causal Criteria Analysis (JOURNAL)
Objectives In the last decade, we saw an upsurge of studies evaluating the role of ecosystem goods and services (EGS) on human health (Eco-Health). Most of this work consists of observational research of intermediate processes and few address the full pathways from ecosystem to E...
Examining the Effects of Mosaic Land Cover on Extreme Events in Historical Downscaled WRF Simulations (PRESENTATION)
The representation of land use and land cover (hereby referred to as “LU”) is a challenging aspect of dynamically downscaled simulations, as a mesoscale model that is utilized as a regional climate model (RCM) may be limited in its ability to represent LU over multi-d...
An Isotopic view of water and nitrogen transport through the vadose zone. (PRESENTATION)
Groundwater nitrate contamination affects thousands of households in Oregon’s southern Willamette Valley and many more across the Pacific Northwest. The southern Willamette Valley Groundwater Management Area (SWV GWMA) was established in 2004 due to nitrate levels in the g...
ExpoCast Framework for Rapid Exposure Forecasts (ISES ExpoDat symposium presentation) (PRESENTATION)
The U.S. E.P.A. ExpoCast project uses high throughput exposure models (simulation) and any easily-obtained exposure heuristics to generate forward predictions of potential exposures from chemical properties. By comparison with exposures inferred via reverse pharmacokinetic modeli...
IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (RDX) (External Review Draft) (IRIS ASSESSMENT)
The IRIS Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) was released for external peer review in September 2016. The EPA’s Science Advisory Board’s (SAB) Chemical Assessment Advisory Committee (CAAC) will conduct a peer review of the scientific basis suppor...
A framework for an alternatives assessment dashboard for evaluating chemical alternatives applied to flame retardants for electronic applications (JOURNAL)
The goal of alternatives assessment (AA) is to facilitate a comparison of alternatives to a chemical of concern, resulting in the identification of safer alternatives. A two-stage methodology for comparing chemical alternatives was developed. In the first stage, alternatives are ...