Related Topics: Health Research

Health Research Products in the Science Inventory

Records 1 to 25 of 1345

Understanding the Impact of Exposure Patterns on Risks from Combined Exposures to Multiple Chemicals (PRESENTATION)
The talk was invited so there is no formal abstract. However, the focus of the talk is on the use of exposure information in the evaluation of risks from combined exposures to chemicals. The talk presents a bit of history and several case studies. All empirical data presented hav...
Computational Modeling of Male Reproductive Tract Development for Use in Predictive Toxicology (ASCCT meeting) (PRESENTATION)
Adverse trends in male reproductive health have been reported for increased rates of testicular germ cell tumor, low semen quality, cryptorchidism, and hypospadias. An association with prenatal environmental exposure has been inferred from human and animal studies underlying male...
Predicting Exposure to Consumer-Products Using Agent-Based Models Embedded with Needs-Based Artificial Intelligence and Empirically -Based Scheduling Models (PRESENTATION)
Information on human behavior and consumer product use is important for characterizing exposures to chemicals in consumer products and in indoor environments. Traditionally, exposure-assessors have relied on time-use surveys to obtain information on exposure-related behavior. In ...
Strengthening Resiliency in Coastal Watersheds: An Ecosystem Services and Ecological Integrity Decision Support System. (PRESENTATION)
To promote and strengthen the resiliency of coastal watersheds in the face of climate change and development, ecological outcomes as well as economic, social, and environmental justice issues need to be considered. An integrated assessment framework is being developed to help wat...
20161116 - Towards Building an AOP-based Prenatal Developmental Toxicity Ontology (CEFIC LRI Workshop - Brussels) (PRESENTATION)
Ontologies are a way to formalize domain-specific scientific knowledge. A developmental ontology would help researchers describe the pathways and processes critical to embryonic development and provide a way to link their chemical disruption to adverse outcomes. Designing one for...
20161116 - Virtual Embryo: Cell-Agent Based Modeling of Developmental Processes and Toxicities (CSS BOSC) (PRESENTATION)
Spatial regulation of cellular dynamics is fundamental to morphological development. As such, chemical disruption of spatial dynamics is a determinant of developmental toxicity. Incorporating spatial dynamics into AOPs for developmental toxicity is desired but constrained by the ...
Contaminants of Emerging Concern During De Facto Water Reuse (PRESENTATION)
Our drinking water and wastewater cycles are integrally linked. Chemicals that are present in household wastewater may be sufficiently mobile and persistent to survive both on-site or municipal wastewater treatment and post-discharge environmental processes. Thus, such contamin...
Developing a rich definition of the person/residence to support person-oriented models of consumer product usage (PRESENTATION)
Person Oriented Models (POMs) provide a basis for simulating aggregate chemical exposures in a population over time (Price and Chaisson, 2005). POMs assign characteristics to simulated individuals that are used to determine the individual’s probability of interacting with e...
20161106 - Human Pluripotent Stem Cell-Based Assay Predicts Developmental Toxicity Potential of ToxCast Chemicals (ACT meeting) (PRESENTATION)
Worldwide initiatives to screen for toxicity potential among the thousands of chemicals currently in use require inexpensive and high-throughput in vitro models to meet their goals. The devTOX quickPredict platform is an in vitro human pluripotent stem cell-based assay used to as...
Metabolic Disruption Early in Life is Associated With Latent Carcinogenic Activity of Dichloroacetic Acid in Mice (JOURNAL)
Early-life environmental factors can influence later-life susceptibility to cancer. Recent evidence suggests that metabolic pathways may mediate this type of latency effect. Previously, we reported that short-term exposure to dichloroacetic acid (DCA) increased liver cancer in mi...
Comparing rat and rabbit embryo-fetal developmental toxicity studies for 379 pharmaceuticals: On systemic dose and developmental effects (Critical Reviews in Toxicology) (JOURNAL)
A database of embryo-fetal developmental toxicity (EFDT) studies of 379 pharmaceutical compounds in rat and rabbit was analyzed for species differences based on toxicokinetic parameters of area under the curve (AUC) and maximum concentration (Cmax) at the developmental adverse ef...
Comparison of rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects (Critical Reviews in Toxicology) (JOURNAL)
Regulatory non-clinical safety testing of human pharmaceutical compounds typically requires embryo fetal developmental toxicity (EFDT) testing in two species, (one rodent and one non-rodent, usually the rat and the rabbit). The question has been raised whether under some conditio...
Computational Systems Toxicology: recapitulating the logistical dynamics of cellular response networks in virtual tissue models (Eurotox_2017) (PRESENTATION)
Translating in vitro data and biological information into a predictive model for human toxicity poses a significant challenge. This is especially true for complex adaptive systems such as the embryo where cellular dynamics are precisely orchestrated in space and time. Computer ce...
Finding Toxicological Tipping Points from High-Content Imaging Data (WC10) (PRESENTATION)
A key challenge to using in vitro data in risk assessment is differentiating between chemical-induced adaptive versus adverse cellular responses. To further investigate this issue, we studied the effects of hundreds of chemicals in HepG2 cells using high-content imaging (HCI). HC...
Mechanistic modeling of developmental defects through computational embryology (WC10th) (PRESENTATION)
Abstract: An important consideration for 3Rs is to identify developmental hazards utilizing mechanism-based in vitro assays (e.g., ToxCast) and in silico predictive models. Steady progress has been made with agent-based models that recapitulate morphogenetic drivers for angiogen...
Fun with High Throughput Toxicokinetics (CalEPA webinar) (PRESENTATION)
Thousands of chemicals have been profiled by high-throughput screening (HTS) programs such as ToxCast and Tox21. These chemicals are tested in part because there are limited or no data on hazard, exposure, or toxicokinetics (TK). TK models aid in predicting tissue concentrations ...
In vitro data and in silico models for computational toxicology (Teratology Society ILSI HESI workshop) (PRESENTATION)
The challenge of assessing the potential developmental health risks for the tens of thousands of environmental chemicals is beyond the capacity for resource-intensive animal protocols. Large data streams coming from high-throughput (HTS) and high-content (HCS) profiling of biolog...
Computational embryology as an integrative platform for predictive DART (45th Conf of Europ Teratology Society) (PRESENTATION)
Chemical regulation is challenged by the large number of chemicals requiring assessment for potential human health and environmental impacts. For example, the USEPA lists more than 85,000 chemicals on its inventory of substances that fall under the Toxic Substances Control Act (T...
Systems Toxicology of Embryo Development (9th Copenhagen Workshop) (PRESENTATION)
An important consideration for predictive toxicology is to identify developmental hazards utilizing mechanism-based in vitro assays (e.g., ToxCast) and in silico multiscale models. Steady progress has been made with agent-based models that recapitulate morphogenetic drivers for a...
Identifying "known unknowns": A comparison between ChemSpider and the US EPA's CompTox Dashboard (ACS Spring National meeting) 1 of 7 (PRESENTATION)
Non-targeted analysis (NTA) workflows in high-resolution mass spectrometry require mechanisms for compound identification. One strategy for tentative identification is the use of online chemical databases such as ChemSpider. Databases like this use molecular formulae and monois...
Programming microphysiological systems for children's health protection (SEBM meeting) (PRESENTATION)
Presentation: Programming microphysiological systems for children’s health protectionAuthors: Knudsen1 T, Klieforth2 B, and Slikker3 W Jr.1National Center for Computational Toxicology/EPA, Research Triangle Park NC2National Center for Environmental Research/EPA, Washington DC3Nat...
Influences of serum from ozone-exposed pregnant rats in an in vitro model of implantation (PRESENTATION)
In our previous studies, ozone (O3) exposure during implantation [gestational day (GD) 5 and 6)] in rats resulted in intrauterine growth restriction (IUGR), suggesting impairment of implantation with exposure. The aim of this study was to (1) determine if serum collected from pre...
Systematic Review: Concept and Tool Development with Application in the Integrated Risk Information System (IRIS) Assessment Process (PRESENTATION)
Systematic Review: Concept and tool development with application to the National Toxicology Program (NTP) and the Integrated Risk Information System (IRIS) Assessment Processes. There is growing interest within the environmental health community to incorporate systematic review m...
Integrating Evidence Within and Across Evidence Streams Using Qualitative Methods (PRESENTATION)
There is high demand in environmental health for adoption of a structured process that evaluates and integrates evidence while making decisions transparent. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework holds promise to address this deman...
Chemical Mixtures Health Risk Assessment of Environmental Contaminants: Concepts, Methods, Applications: Handbook (PRESENTATION)
This problems-based, half-day, introductory workshop focuses on methods to assess health risks posed by exposures to chemical mixtures in the environment. Chemical mixtures health risk assessment methods continue to be developed and evolve to address concerns over health risks f...