Related Topics: Health Research

Health Research Products in the Science Inventory

Records 1 to 25 of 1927

EnviroAtlas Efforts to Reach Tomorrow's Decision Makers (PRESENTATION)
The movement towards infrastructure resilience can be strengthened by including ecosystem services (ES). The EnviroAtlas, developed by the U.S. Environmental Protection Agency and partners, provides a collection of web-based, interactive maps and resources for exploring ES and t...
Fine-scale health-related measures of exposure to urban green spaces (PRESENTATION)
Nature’s benefits to society, also known as ecosystem services, contribute to many aspects of public health and well-being. Green infrastructure routinely buffers both natural and man-made hazards. It is also a source of healthful exposures due to promoting physical activi...
Supporting LHD Capacities in Environmental Health and Land Reuse (PRESENTATION)
Description: In this interactive session, attendees will learn about activities of the Brownfields & Reuse Opportunity Working Network’s (BROWN) Health Education Working Group. BROWN partners range from environmental professionals to public health officials to private s...
The Influence of Maternal High Fat Diet and Ozone Exposure on Serum Metabolomic Profiles in Juvenile Offspring (PRESENTATION)
There is a growing interest in understanding how maternal diet can affect the sensitivity of offspring to environmental exposures. Previous studies have demonstrated that adult offspring from dams given a high fat diet (HFD) prior to, during, and after pregnancy had elevated pul...
Life Cycle Assessment of Cooking Fuel Systems in India, China, Kenya, and Ghana (PUBLISHED REPORT)
Daily use of traditional cooking fuels and stoves in India, China, Kenya, and Ghana emits harmful air pollutants that result in over a million premature deaths annually. Reducing pollution from cookstoves is a key priority, as emissions from traditional cookstoves and open fires ...
Residential Greenspace and Children’s Respiratory Health (PRESENTATION)
This power point slide file will support a presentation at the Joint Annual Meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology (ISES-ISEE 2018).
Human Health Toxicity Values for Perfluorobutane Sulfonic Acid (CASRN 375-73-5) and Related Compound Potassium Perfluorobutane Sulfonate (CASRN 29420-49-3) (ASSESSMENT DOCUMENT)
The human health toxicity assessment document for PFBS/K+PFBS identifies and characterizes the health hazards of these chemicals and includes information to address the first two steps of the risk assessment process: hazard identification and dose-response.
20180509 - Modelling The Biological Complexity Of Our Environment (Douglas Connect RTP) (PRESENTATION)
High-throughput data-driven approaches provide alternative toxicity testing strategy. A broad array of computational predictive approaches can be used to predict chemical-induced effects. However, linking complex disparate data-streams is challenging. Tipping point analysis rigor...
Working with Tribes to Assess, Manage, and Improve Ecosystem Function through EPA’s Science to Achieve Results (STAR) Grants Program and Collaborative Research Projects (SUMMARY)
The summary demonstrates how tribes use traditional knowledge/Traditional Ecological knowledge and technical tools and support from EPA in addressing environmental concerns. We highlighted two projects where EPA worked directly with tribes to conduct Riparian Proper Functioning C...
Cumulative risk assessment: Asking the right questions (PRESENTATION)
This is a talk. The topics covered in the talk will include the following: Background discussions of Chemical Risk Assessment, Chemical Mixtures Risk Assessment, and Ecological Risk Assessment; Description of Cumulative Risk Assessment and why one might consider undertaking suc...
Application of the Human Well-Being Index to Sensitive Population Divisions: A Children's Well-Being Index Development (JOURNAL)
The assessment of community well-being is critical as an end-point measure that will facilitate decision support and assist in the identification of sustainable solutions to address persistent problems. While the overall measure is important, it is equally vital to distinguish va...
A systematic evaluation of analogs and automated read-across prediction of estrogenicity: A case study using hindered phenols (JOURNAL)
Read-across is an important data gap filling technique used within category and analog approaches for regulatory hazard identification and risk assessment. Although much technical guidance is available that describes how to develop category/analog approaches, practical principles...
Formation of the Blood-Brain Barrier and Susceptibilities to Toxicants (PRESENTATION)
Recent evidence suggests that gene expression within the blood-brain barrier (BBB) may be involved in the etiology of some neurodevelopmental disorders. For example, autism spectrum disorder (ASD) has been linked to SLC7A5, an amino acid transporter localized at the BBB that play...
Computational model of the neurovascular unit (cNVU) for predictive toxicology of blood-brain-barrier development (PRESENTATION)
Development of a functional blood-brain barrier (BBB) is a complex process regulated by multiple cell types. BBB development consists of several key events during heterotypic cellularization of the embryonic neuroepithelium: vascular invasion and patterning from the perineural va...
An Integrative Systems Toxicology Model for Neurovascular Developmental Toxicity (PRESENTATION)
The blood-brain barrier (BBB) limits passage of toxicants into brain tissue and may be an important tissue interface for developmental neurotoxicity, although the extent to which drugs and chemicals interact with BBB anatomical development is not well known. We utilized a computa...
Integrating in vitro and in silico data in a model of neurovascular developmental toxicity (PRESENTATION)
Although perturbed blood-brain barrier (BBB) function has been implicated in some neurobehavioral disorders, it is unclear whether developmental toxicant exposure impacts BBB formation. We utilized a computational systems model of the neurovascular unit (cNVU) in concert with in ...
Computational Modeling of Developmental Toxicity: Modeling with Human Pluripotent Stem Cells (PRESENTATION)
Presentation at Brazialian Congress of Toxicology on Computational Modeling of Developmental Toxicity: Modeling with Human Pluripotent Stem Cells
Computational Modeling of Developmental Toxicity (PRESENTATION)
Presentation at International Conference on Reproductive Biology and Toxicology Oct 2017 on Computational Biology
Estimating Asthma, Myocardial Infarction, and Heart Failure Hospitalizations and Emergency Room Visits in New York City from Exposure to Ambient Fine Particulate Matter using a Hierarchical Bayesian Model Approach (PRESENTATION)
Fine particulate matter has been shown to influence the frequency and severity of respiratory and cardiovascular diseases, and also increases inflammatory proteins and heart rate variability (HRV). A novel approach was developed to reduce the spatial and temporal gaps in the ambi...
Rubbertown NGEM Demonstration Project Community Meeting 4 (PRESENTATION)
These slides provide an update on the Rubbertown NGEM Demonstration Project that began in September 2017. Project background: Industrial...
Computational Toxicology and Computational Modeling of Embryonic Limb Development using ToxCast High-throughput Screening Data (Teratology Society Annual Meeting) (PRESENTATION)
Skeletal defects are one of the major adverse outcomes observed across many prenatal developmental toxicity studies. We mined the ToxCast database (ToxCastDB) for in vitro chemical-bioactivity profiles that significantly correlated with skeletal defects in the Toxicity Reference ...
Systems toxicology model of neurovascular development (Teratology Society Annual Meeting) (PRESENTATION)
Angiogenesis is required for normal central nervous system development. The embryonic neuroepithelium does not generate vascular progenitors but is instead vascularized by angiogenic sprouts from the perineural vascular plexus. The pathways underlying neurovascular interactions t...
Quantitative prediction of microcephaly utilizing cell agent-based modeling: profiling the centrosome cycle (Teratology Society Annual Meeting) (PRESENTATION)
Microcephaly is a human birth defect that is precipitated by diverse genetic and environmental factors including recessive mutations in the centrosome cycle, prenatal exposure to alcohol or methylmercury, and maternal Rubella or Zika viral infections. A computational model of the...
Computational modeling of the neurovascular unit to predict microglia mediated effects on blood-brain barrier formation (Teratology Society Annual Meeting) (PRESENTATION)
Development of a functional blood-brain barrier (BBB) is a complex process regulated by multiple cell types at different developmental stages. One important aspect of the developing neurovascular unit (NVU) involves interaction between invading endothelial cells, neuroprogenitor ...
Recapitulating Human Endocardial Cushion Morphogenesis with OCMs and Microfluidics (PRESENTATION)
The potential for chemical exposure to produce developmental toxicity has not been evaluated for thousands of chemicals; therefore, experimental and computational models are needed to prioritize untested chemicals. Heart defects are among the most common structural malformations ...