Related Topics: Health Research

Health Research Products in the Science Inventory

Records 1 to 25 of 1274

Product Use Scheduler: A Scheduling Module used in EPA’s Human Exposure Model (PRESENTATION)
The scheduling model (SM) was developed for scheduling the use of consumer products in the U.S. EPA’s Human Exposure Model (HEM), an integrated modeling system to estimate human exposure to chemicals in household consumer products. The SM begins with year-long daily activit...
Characterizing Exposure-Related Behaviors Using Agent-Based Models Embedded with Needs-Based Artificial Intelligence (PRESENTATION)
Information on where and how individuals spend their time is important for characterizing exposures to chemicals in consumer products and in indoor environments. Traditionally, exposure assessors have relied on time-use surveys in order to obtain information on exposure-related b...
Trends in Cumulative Exposures of Six Phthalates in the United States from 2005 to 2014 (PRESENTATION)
Phthalates are utilized in a wide range of consumer goods and are common contaminants in food. Exposures and resulting dosages of individual phthalates vary over time as a result of changes in their use in consumer products and food contact materials. We calculated the trends in ...
A Literature Review and Data Mining Project to Identify Associations between Stressors and Health Outcomes for Children (PRESENTATION)
Children are often more vulnerable than adults to the effects of environmental contaminants found in their everyday environments. Their dynamic growth and unique interactions with the built, natural, and social environments may result in a greater susceptibility to chemical and n...
Modified HWBI Model(s) Linking Service Flows to Well-Being Endpoints: Accounting for Environmental Quality (PUBLISHED REPORT)
This report describes an approach for modifying ORD’s Human Well-Being Index (HWBI) to increase its utility by introducing a composite index developed independently of the HWBI effort. Using ORD’s Environmental Quality Index (EQI), this research examines the potential...
Hospital visits for gastrointestinal Illness after a major water main break in 2010 (PRESENTATION)
Background/Aim Water main breaks can occur due to the stresses of an aging infrastructure and changing climate. Water main breaks are a public health concern because they can cause pressure transients (specifically, abrupt decreases in water pressure/flow in the pipeline), which ...
Sex Differences in Placental Mitochondrial Function Associated with Ozone-Induced Fetal Growth Restriction (PRESENTATION)
Fetal growth restriction is a major underlying cause of infant mortality worldwide. Despite knowledge of risk factors for adverse pregnancy outcomes, the mechanisms that drive compromised growth during pregnancy have not been well established. Placental maladaptation, particularl...
Update for Chapter 5 of the Exposure Factors Handbook: Soil and Dust Ingestion (PUBLISHED REPORT)
This update includes new information on soil and dust ingestion that has become available since the <em>Exposure Factors Handbook: 2011 Edition</em> was released. The recommended values have also been revised, as needed, to reflect the new information. This chapter explains the ...
20170612 - Fun with High Throughput Toxicokinetics (CalEPA webinar) (PRESENTATION)
Thousands of chemicals have been profiled by high-throughput screening (HTS) programs such as ToxCast and Tox21. These chemicals are tested in part because there are limited or no data on hazard, exposure, or toxicokinetics (TK). TK models aid in predicting tissue concentrations ...
20170624 - In vitro data and in silico models for computational toxicology (Teratology Society ILSI HESI workshop) (PRESENTATION)
The challenge of assessing the potential developmental health risks for the tens of thousands of environmental chemicals is beyond the capacity for resource-intensive animal protocols. Large data streams coming from high-throughput (HTS) and high-content (HCS) profiling of biolog...
20170907- Computational embryology as an integrative platform for predictive DART (45th Conf of Europ Teratology Society) (PRESENTATION)
Chemical regulation is challenged by the large number of chemicals requiring assessment for potential human health and environmental impacts. For example, the USEPA lists more than 85,000 chemicals on its inventory of substances that fall under the Toxic Substances Control Act (T...
Identification of vascular disruptor compounds by a tiered analysis in ebrafish embryos and mouse embryonic endothelial cells (JOURNAL)
The large number of diverse chemicals in production or in the environment has motivated medium to high throughput in vitro or small animal approaches to efficiently profile chemical-biological interactions and to utilize this information to assess risks of chemical exposures on h...
EMBRYONIC VASCULAR DISRUPTION ADVERSE OUTCOMES: LINKING HIGH THROUGHPUT SIGNALING SIGNATURES WITH FUNCTIONAL CONSEQUENCES (JOURNAL)
Embryonic vascular disruption is an important adverse outcome pathway (AOP) given the knowledge that chemical disruption of early cardiovascular system development leads to broad prenatal defects. High throughput screening (HTS) assays provide potential building blocks for AOP d...
Identifying Prevalent Chemical Mixtures in the US Population (JOURNAL)
Through the food and water they ingest, the air they breathe, and the consumer products with which they interact at home and at work, humans are exposed to tens of thousands of chemicals, many of which have not been evaluated to determine their potential toxicities. In recent yea...
Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability (JOURNAL)
We incorporate inter-individual variability, including variability across demographic subgroups, into an open-source high-throughput (HT) toxicokinetics (TK) modeling framework for use in a next-generation risk prioritization approach. Risk prioritization involves rapid triage of...
20170504 - Systems Toxicology of Embryo Development (9th Copenhagen Workshop) (PRESENTATION)
An important consideration for predictive toxicology is to identify developmental hazards utilizing mechanism-based in vitro assays (e.g., ToxCast) and in silico multiscale models. Steady progress has been made with agent-based models that recapitulate morphogenetic drivers for a...
Computational Model of Secondary Palate Fusion and Disruption (JOURNAL)
Morphogenetic events are driven by cell-generated physical forces and complex cellular dynamics. To improve our capacity to predict developmental effects from cellular alterations, we built a multi-cellular agent-based model in CompuCell3D that recapitulates the cellular networks...
Sex Differences in Placental Mitochondrial Function Associated with Ozone-Induced Fetal Growth Restriction. (PRESENTATION)
Fetal growth restriction is a major underlying cause of infant mortality worldwide. Unfortunately little is known about the mechanisms that drive compromised growth and the role of placental maladaptation on fetal development. In the current study placentas from male and female r...
Occupational Exposure to Pesticides and the Incidence of Lung Cancer in the Agricultural Health Study (JOURNAL)
Background: Occupational pesticide use is associated with lung cancer in some, but not all, epidemiologic studies. In the Agricultural Health Study (AHS), we previously reported positive associations between several pesticides and lung cancer incidence. Objective: We evaluated u...
20170422 - Programming microphysiological systems for children's health protection (SEBM meeting) (PRESENTATION)
Presentation: Programming microphysiological systems for children&amp;rsquo;s health protectionAuthors: Knudsen1 T, Klieforth2 B, and Slikker3 W Jr.1National Center for Computational Toxicology/EPA, Research Triangle Park NC2National Center for Environmental Research/EPA, Washing...
20170403 - Identifying "known unknowns": A comparison between ChemSpider and the US EPA's CompTox Dashboard (ACS Spring National meeting) 1 of 7 (PRESENTATION)
Non-targeted analysis (NTA) workflows in high-resolution mass spectrometry require mechanisms for compound identification. One strategy for tentative identification is the use of online chemical databases such as ChemSpider. Databases like this use molecular formulae and monois...
Identifying known unknowns using the US EPA's CompTox Chemistry Dashboard (JOURNAL)
Chemical features observed using high-resolution mass spectrometry can be tentatively identified using online chemical reference databases by searching molecular formulae and monoisotopic masses and then rank-ordering of the hits using appropriate relevance criteria. The most li...
Freshwater Fish Communities (BOOK CHAPTER)
Freshwater fish are ecologically important in stream ecosystems, and they provide people with significant food, recreation, and conservation value as biological indicator of freshwater streams. Historically, the streams and rivers of southern New England supported moderately dive...
THE MOUSE THERMOREGULATORY SYSTEM:ITS IMPACT ON TRANSLATING BIOMEDICAL DATA TO HUMANS (JOURNAL)
The laboratory mouse has become the predominant test species in biomedical research. The number of papers that translate or extrapolate data from mouse to human has grown exponentially since the year 2000. There are many physiological and anatomical factors to consider in the pro...
Computer Simulation of Developmental Processes and Toxicities (SOT) (PRESENTATION)
Rationale: Recent progress in systems toxicology and synthetic biology have paved the way to new thinking about in vitro/in silico modeling of developmental processes and toxicities, both for embryological and reproductive impacts. Novel in vitro platforms such as 3D organotypic ...