Related Topics: Health Research

Health Research Products in the Science Inventory

Records 1 to 25 of 528

Brominated Flame Retardants. (BOOK CHAPTER)
BFRs belong to a growing group of organohalogen chemicals. They can be highly persistent, bioaccumulative and cause adverse effects in humans and wildlife. Although some BFRs are banned or voluntarily withdrawn from usage by the manufacturer, emerging and existing BFRs continue t...
Where do we go from here: Challenges and the future of endocrine disrupting compound screening and testing (JOURNAL)
ABSTRACTWorldwide concern about the impacts of endocrine disrupting compounds on both human and environmental health has led to implementation of multiple screening and testing programs. In most cases these programs have focused on impacts to the estrogen, androgen and thyroid h...
The Use of Purified Rat Leydig Cells Complements the H295R Screen to Detect Chemical-Induced Alterations in Testosterone Production (JOURNAL)
Exposure to endocrine disrupting contaminants can compromise testosterone production and lead to abnormal male reproductive development and altered spermatogenesis. In vitro high throughput screening (HTS) assays are needed to evaluate risk to testosterone production, yet the mai...
Adverse outcome pathway networks I: Development and applications (JOURNAL)
The US EPA is developing more cost effective and efficient ways to evaluate chemical safety using high throughput and computationally based testing strategies. An important component of this approach is the ability to translate chemical effects on fundamental biological processes...
Adverse outcome pathway networks II: Network analytics (JOURNAL)
The US EPA is developing more cost effective and efficient ways to evaluate chemical safety using high throughput and computationally based testing strategies. An important component of this approach is the ability to translate chemical effects on fundamental biological processes...
Adverse outcome pathway networks: Development, analytics and applications (PRESENTATION)
The US EPA is developing more cost effective and efficient ways to evaluate chemical safety using high throughput and computationally based testing strategies. An important component of this approach is the ability to translate chemical effects on fundamental biological processes...
Gene transcription ontogeny of hypothalamic-pituitary-thyroid-axis development in early-life stage fathead minnow and zebrafish (PRESENTATION)
Disruption of thyroid hormone signaling is a form of endocrine disruption that is of concern to both human health and ecosystems. Research is being conducted to define the biological targets chemicals may interact with to disrupt thyroid hormone signaling and the stages in develo...
SeqAPASS to evaluate conservation of high-throughput screening targets across non-mammalian species (PRESENTATION)
Cell-based high-throughput screening (HTS) and computational technologies are being applied as tools for toxicity testing in the 21st century. The U.S. Environmental Protection Agency (EPA) embraced these technologies and created the ToxCast Program in 2007, which has served as a...
AOP-informed assessment of endocrine disruption in freshwater crustaceans (PRESENTATION)
To date, most research focused on developing more efficient and cost effective methods to predict toxicity have focused on human biology. However, there is also a need for effective high throughput tools to predict toxicity to other species that perform critical ecosystem functio...
Structure-based Understanding of Binding Affinity and Mode of Estrogen Receptor α Agonists and Antagonists. (JOURNAL)
The flexible hydrophobic ligand binding pocket (LBP) of estrogen receptor α (ERα) allows the binding of a wide variety of endocrine disruptors. Upon ligand binding, the LBP reshapes around the contours of the ligand and stabilizes the complex by complementary hydrophobic interact...
On Selecting a Minimal Set of In Vitro Assays to Reliably Determine Estrogen Agonist Activity (JOURNAL)
The US EPA is charged with screening chemicals for their ability to be endocrine disruptors through interaction with the estrogen, androgen and thyroid axes. The agency is starting to explore the use of high-throughput in vitro assays to use in the Endocrine Disruptor Screening P...
Development of a Screening Approach to Detect Thyroid Disrupting Chemicals that Inhibit the Human Sodium/Iodide Symporter (NIS) (JOURNAL)
Thyroid hormone synthesis requires active iodide uptake mediated by the sodium/iodide symporter (NIS). Monovalent anions, such as the environmental contaminant perchlorate, have been well characterized as competitive inhibitors of NIS, yet limited information exists for more stru...
Effects of an Environmentally-relevant Mixture of Pyrethroid Insecticides on Spontaneous Activity in Primary Cortical Networks on Microelectrode Arrays (JOURNAL)
Pyrethroid insecticides exert their insecticidal and toxicological effects primarily by disrupting voltage-gated sodium channel (VGSC) function, resulting in altered neuronal excitability. Numerous studies of individual pyrethroids have characterized effects on mammalian VGSC fun...
Twenty-five years after "Wingspread"- Environmental endocrine disruptors (EDCs) and human health (JOURNAL)
The development of life-stage and tissue-specific AOPs for EDCs can reduce the uncertainty in extrapolating of the effects of EDCs from in vitro and in vivo studies in laboratory animals to humans. When the key events (KEs) and molecular initiating event (MIEs) in a pathway are...
Derivation and evaluation of putative adverse outcome pathways for the effects of cyclooxygenase inhibitors on reproductive processes in female fish (JOURNAL)
Cyclooxygenase (COX) inhibition is of concern in fish because COX inhibitors (e.g., ibuprofen) are ubiquitous in aquatic systems/fish tissues, and can disrupt synthesis of prostaglandins that modulate a variety of essential biological functions including reproduction. High conten...
Testicular oocytes in smallmouth bass in northeastern Minnesota in relation to varying levels of human activity (JOURNAL)
Testicular oocytes (TOs) have been found in black basses (Micropterus spp.) from many locations in North America. The presence of TOs is often assumed to imply exposure to endocrine disrupting compounds (EDCs), however, a definitive causal relationship has yet to be established,...
A reduced transcriptome approach to assess environmental toxicants using zebrafish embryo tests (JOURNAL)
This paper reports on the pilot testing of a new bioassay platform that monitors expression of 1600 genes in zebrafish embryos exposed to either single chemicals or complex water samples. The method provides a more cost effective, high throughput means to broadly evaluate the pot...
Nanotechnology Applications (BOOK CHAPTER)
This book chapter discusses various nanotechnologies for water sustainability. Detailed information on catalysis as an advanced oxidation process, nanofiltration, adsorption, water disinfection, and groundwater remediation is provided for water treatment. These nanomaterials effe...
CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity (SOT) (PRESENTATION)
In order to protect human health from chemicals that can mimic natural hormones, the U. S. Congress mandated the U.S. EPA to screen chemicals for their potential to be endocrine disruptors through the Endocrine Disruptor Screening Program (EDSP). However, the number of chemicals ...
Domain-Specific QSAR Model for Identifying Potential Estrogenic Activity of Phenols (ASCCT annual meeting) (PRESENTATION)
Humans are potentially exposed to tens of thousands of man-made chemicals in the environment, some of which may mimic natural endocrine hormones and thus have the potential to be endocrine disruptors. Predictive in silico tools can be used to quickly and efficiently evaluate thes...
Survey of ecotoxicologically-relevant reproductive endpoint coverage within the ECOTOX database across ToxCast ER agonists (SETAC) (PRESENTATION)
Adipose tissue represents an important and understudied component of the endocrine system. Recent evidence suggests that endocrine-disrupting chemicals (EDCs) may be able to alter lipid development (e.g., adipogenesis) and/or the balance of lipid metabolism. The environmentally a...
Identification of Potential Sodium Iodide Symporter (NIS) Inhibitors in ToxCast Phase1_v2 Chemical Library Using in vitro Radioactive Iodide Uptake (RAIU) Assay (PRESENTATION)
Identification of Potential Sodium Iodide Symporter (NIS) Inhibitors in ToxCast Phase1_v2 Chemical Library Using in vitro Radioactive Iodide Uptake (RAIU) Assay Jun Wang1,2, Daniel R. Hallinger2, Ashley S. Murr2, Angela R. Buckalew1, Tammy E. Stoker2, Susan C. Laws21Oak Ridge In...
TITLE: Twenty-five years after “Wingspread” – Environmental endocrine disruptors (EDCs) and human health: EDSP, HTS, AOPs, and TSCA (PRESENTATION)
The aim of this paper is to provide the reader with a view of the Endocrine Disruptor Chemical (EDC) research field and its relevance to human health. My perspective is from working on the effects of EDCs that act via the androgen (A) or estrogen (E) signaling pathways in a regul...
Extrapolation of mammalian-based ToxCast assay results to non-mammalian species to evaluate endocrine disruption (PRESENTATION)
In vitro high-throughput screening (HTS) and in silico technologies have emerged as 21st century tools for chemical hazard identification. In 2007 the U.S. Environmental Protection Agency (EPA) launched the ToxCast Program, which has screened thousands of chemicals in hundreds of...
A method for CRISPR/Cas9 mutation of genes in fathead minnow (PRESENTATION)
Product Description: CRISPR/Cas9 is a system that can be used to disrupt a gene of interest in any animal. It allows us to study each gene’s role by observing changes in the animal when the gene isn’t functional. We worked out a method to use this technology in the f...