Related Topics: Health Research

Health Research Products in the Science Inventory

Records 1 to 25 of 439

Structure-based Understanding of Binding Affinity and Mode of Estrogen Receptor α Agonists and Antagonists. (JOURNAL)
The flexible hydrophobic ligand binding pocket (LBP) of estrogen receptor α (ERα) allows the binding of a wide variety of endocrine disruptors. Upon ligand binding, the LBP reshapes around the contours of the ligand and stabilizes the complex by complementary hydropho...
Consensus models to predict endocrine disruption for all human-exposure chemicals (AAAS Annual Meeting) (PRESENTATION)
Humans are potentially exposed to tens of thousands of man-made chemicals in the environment. It is well known that some environmental chemicals mimic natural hormones and thus have the potential to be endocrine disruptors. Most of these environmental chemicals have never been te...
Structure-Based Understanding of Binding Affinity and Mode of Estrogen Receptor α Agonists and Antagonists (PRESENTATION)
The flexible hydrophobic ligand binding pocket (LBP) of estrogen receptor α (ERα) allows the binding of a wide variety of endocrine disruptors. Upon ligand binding, the LBP reshapes around the contours of the ligand and stabilizes the complex by complementary hydrophobic interact...
Application of Adverse Outcome Pathways (AOPs) in Human Health and Ecotoxicology Capturing Divergent Consequences of Conserved Molecular Initiating Events via AOP Networks (Presentation) (PRESENTATION)
The adverse outcome pathway (AOP) framework was developed to help organize and disseminate existing knowledge concerning the means through which specific perturbations of biological pathways can lead to adverse outcomes considered relevant to risk-based regulatory decision-making...
Developing confidence in adverse outcome pathway-based toxicity predictions effects of the fungicide imazalil on fathead minnow reproduction (Poster) (PRESENTATION)
An adverse outcome pathway (AOP) description linking inhibition of aromatase (cytochrome P450 [cyp] 19) to reproductive dysfunction was reviewed for scientific and technical quality and endorsed by the OECD. An intended application of the AOP framework is to support the use of me...
Cross-species assay validation using the AOP “deiodinase inhibition leading to impaired posterior chamber inflation” (PRESENTATION)
High throughput screening assays able to detect chemical interactions with specific biological targets are increasingly being used to identify chemicals that could be hazardous to humans or wildlife. Most of these assays examine interaction with mammalian proteins. The present wo...
Developing confidence in adverse outcome pathway-based toxicity predictions effects of the fungicide imazalil on fathead minnow reproduction (PRESENTATION)
An adverse outcome pathway (AOP) description linking inhibition of aromatase (cytochrome P450 [cyp] 19) to reproductive dysfunction was reviewed for scientific and technical quality and endorsed by the OECD (https://aopwiki.org/wiki/index.php/Aop:25). An intended application of t...
Application of adverse outcome pathways (AOPs) in human health and ecotoxicology capturing divergent consequences of conserved molecular initiating events via AOP networks (PRESENTATION)
The adverse outcome pathway (AOP) framework was developed to help organize and disseminate existing knowledge concerning the means through which specific perturbations of biological pathways can lead to adverse outcomes considered relevant to risk-based regulatory decision-making...
Application of Computational and High-Throughput in vitro screening for prioritization (Beijing, China, RCES, CAS talk) (PRESENTATION)
Abstract: There are tens of thousands of man-made chemicals to which humans are exposed, but only a fraction of these have the extensive in vivo toxicity data used in most traditional risk assessments. This lack of data, coupled with concerns about testing costs and animal use, a...
Derivation and evaluation of putative adverse outcome pathways for the effects of cyclooxygenase inhibitors on reproductive processes in female fish (JOURNAL)
Cyclooxygenase (COX) inhibition is of concern in fish because COX inhibitors (e.g., ibuprofen) are ubiquitous in aquatic systems/fish tissues, and can disrupt synthesis of prostaglandins that modulate a variety of essential biological functions including reproduction. High conten...
Application of computational and high-throughput in vitro screening for prioritization (ECHA workshop) (PRESENTATION)
Abstract: There are tens of thousands of man-made chemicals to which humans are exposed, but only a fraction of these have the extensive in vivo toxicity data used in most traditional risk assessments. This lack of data, coupled with concerns about testing costs and animal use, a...
Examination of U.S. Puberty Timing Data from 1940 to 1994 for Secular Trends: Panel Findings (JOURNAL)
Five articles based on "The Role of Environmental Factors on the Onset and Progression of Puberty" expert panel workshop findings were published as a Supplement to Pediatrics on Feb. 1, 2008. This workshop, sponsored by EPA, NIEHS, and Serono International and held in November o...
Effects of the fungicide imazalil on the fathead minnow (Pimephales promelas) reproductive axis a case study in 21st century toxicity testing (PRESENTATION)
Since its introduction in 1983, imazalil has been used primarily as a fungicide on crops post-harvest. Its effectiveness lies in the ability to inhibit the fungal cytochrome P450 (cyp), lanosterol 14 á-demethylase. However, like other azole fungicides, imazalil can inhibit...
Validation of the AOP network “Thyroperoxidase and/or deiodinase inhibition leading to impaired swim bladder inflation” (PRESENTATION)
Industrial chemicals released in the aquatic environment can pose risks for both environmental and human health. Fish are widely used sentinels for evaluating aquatic toxicity to vertebrates in order to set environmental quality standards, However, chronic toxicity testing with f...
Dose Response Data for Hormonally Active Chemicals: Estrogens, Antiandrogens and Androgens (PRESENTATION)
The shape of the dose response curve in the low dose region has been debated since the late 1940s. The debate originally focused on linear no threshold (LNT) vs threshold responses in the low dose range for cancer and noncancer related effects. For noncancer effects the defaul...
Cross-species extrapolation of toxicity information using the Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool (PRESENTATION)
In the United States, the Endocrine Disruptor Screening Program (EDSP) was established to identify chemicals that may lead to adverse effects via perturbation of the endocrine system (i.e., estrogen, androgen, and thyroid hormone systems). In the mid-1990s the EDSP adopted a two ...
Effects of the fungicide imazalil on the fathead minnow (Pimephales promelas) reproductive axis a case study in 21st century toxicity testing (PRESENTATION)
Since its introduction in 1983 imazalil has been used primarily as a fungicide on crops post-harvest, such as tubers and citrus fruits. Its effectiveness lies in the ability to inhibit the fungal enzyme, lanosterol 14 á-demethylase. However, like other azole fungicides, im...
Quantitative AOP-based predictions for two aromatase inhibitors evaluating the influence of bioaccumulation on prediction accuracy (PRESENTATION)
The adverse outcome pathway (AOP) framework can be used to support the use of mechanistic toxicology data as a basis for risk assessment. For certain risk contexts this includes defining, quantitative linkages between the molecular initiating event (MIE) and subsequent key events...
Conversion of estrone to estradiol in male fathead minnows: Implications for assessing risk (PRESENTATION)
Estrogens are frequently observed in aquatic environments associated with anthropogenic influence, such as agricultural runoff and wastewater treatment effluent. While 17â-estradiol (E2) is the most potent naturally-occurring estrogen, estrone (E1) is often found at higher ...
Differentiating high priority pathway-based toxicity from non-specific effects in high throughput toxicity data: A foundation for prioritizing AOP development. (PRESENTATION)
The ToxCast chemical screening approach enables the rapid assessment of large numbers of chemicals for biological effects, primarily at the molecular level. Adverse outcome pathways (AOPs) offer a means to link biomolecular effects with potential adverse outcomes at the level of...
Impaired swim bladder inflation in early-life stage fathead minnows exposed to a deiodinase inhibitor, iopanoic acid (PRESENTATION)
The thyroid axis plays a critical role in teleost fish development. The present study investigated whether inhibition of deiodinase, the enzyme which converts thyroxine (T4), to the more biologically-active form, 3,5,3'-triiodothyronine (T3), would impact inflation of the posteri...
RSCABS: An R package for performing the Rao-Scott Adjusted Cochran-Armitage trend test By Slices (PUBLISHED REPORT)
RSCABS[3] (Rao-Scott adjusted Cochran-Armitage trend test By Slices) is a modification to the Rao-Scott[5] adjusted Cochran-Armitage trend test[1, 2] that allows for testing at each individual severity score often seen in histopathological data. The test was originally developed ...
Developments in the EPA Computational Toxicology Program to Identify Environmental Endocrine Disruptors ( Environmental Endocrine Disruptors Gordon Conference) (PRESENTATION)
Presentation at the Environmental Endocrine Disruptors Gordon Conference in Newry, ME June 22, 2016 to give an overview of the use of high throughput screening and high throughput toxicokinetics to build models for endocrine disruption by environmental chemicals for estrogen rece...
CERAPP: Collaborative Estrogen Receptor Activity Prediction Project (JOURNAL)
Humans potentially are exposed to thousands of man-made chemicals in the environment. Some chemicals mimic natural endocrine hormones and, thus, have the potential to be endocrine disruptors. Many of these chemicals never have been tested for their ability to interact with the es...
Gas Phase Probe Molecules for Assessing In vitro Metabolism to Infer an In vivo Response (PRESENTATION)
Efficient and accurate in vitro high-throughput screening (HTS) methods use cellular and molecular based adverse outcome pathways (AOPs) as central elements for exposure assessment and chemical prioritization. However, not all AOPs are based on human or animal systems biology, bu...