Related Topics: Health Research

Health Research Products in the Science Inventory

Records 1 to 25 of 453

Testicular oocytes in smallmouth bass in Northeastern Minnesota in relation to presumed exposure to endocrine disrupting compounds (JOURNAL)
Testicular oocytes (TOs) have been found in black basses (Micropterus spp.) from many locations in North America. The presence of TOs is often assumed to imply exposure to endocrine disrupting compounds (EDCs), however, a definitive causal relationship has yet to be established,...
Identification of Potential Sodium Iodide Symporter (NIS) Inhibitors in ToxCast Phase1_v2 Chemical Library Using in vitro Radioactive Iodide Uptake (RAIU) Assay (PRESENTATION)
Identification of Potential Sodium Iodide Symporter (NIS) Inhibitors in ToxCast Phase1_v2 Chemical Library Using in vitro Radioactive Iodide Uptake (RAIU) Assay Jun Wang1,2, Daniel R. Hallinger2, Ashley S. Murr2, Angela R. Buckalew1, Tammy E. Stoker2, Susan C. Laws21Oak Ridge In...
TITLE: Twenty-five years after “Wingspread” – Environmental endocrine disruptors (EDCs) and human health: EDSP, HTS, AOPs, and TSCA (PRESENTATION)
The aim of this paper is to provide the reader with a view of the Endocrine Disruptor Chemical (EDC) research field and its relevance to human health. My perspective is from working on the effects of EDCs that act via the androgen (A) or estrogen (E) signaling pathways in a regul...
Twenty-five years after "Wingspread"- Environmental endocrine disruptors (EDCs) and human health (JOURNAL)
The development of life-stage and tissue-specific AOPs for EDCs can reduce the uncertainty in extrapolating of the effects of EDCs from in vitro and in vivo studies in laboratory animals to humans. When the key events (KEs) and molecular initiating event (MIEs) in a pathway are...
Development of a Screening Approach to Detect Thyroid Disrupting Chemicals that Inhibit the Human Sodium/Iodide Symporter (NIS) (JOURNAL)
Thyroid hormone synthesis requires active iodide uptake mediated by the sodium/iodide symporter (NIS). Monovalent anions, such as the environmental contaminant perchlorate, have been well characterized as competitive inhibitors of NIS, yet limited information exists for more stru...
Extrapolation of mammalian-based ToxCast assay results to non-mammalian species to evaluate endocrine disruption (PRESENTATION)
In vitro high-throughput screening (HTS) and in silico technologies have emerged as 21st century tools for chemical hazard identification. In 2007 the U.S. Environmental Protection Agency (EPA) launched the ToxCast Program, which has screened thousands of chemicals in hundreds of...
A method for CRISPR/Cas9 mutation of genes in fathead minnow (PRESENTATION)
Product Description: CRISPR/Cas9 is a system that can be used to disrupt a gene of interest in any animal. It allows us to study each gene’s role by observing changes in the animal when the gene isn’t functional. We worked out a method to use this technology in the f...
The use of adverse outcome pathway-based toxicity predictions: A case study evaluating the effects of imazalil on fathead minnow reproduction (PRESENTATION)
Product Description: As a means to increase the efficiency of chemical safety assessment, there is an interest in using data from molecular and cellular bioassays, conducted in a highly automated fashion using modern robotics, to predict toxicity in humans and wildlife. The prese...
Gene transcription ontogeny of thyroid-axis development in early-life stage fathead minnows (Pimephales promelas) (PRESENTATION)
Disruption of thyroid hormone signaling is a form of endocrine disruption that is of concern to both human health and ecosystems. Research is being conducted to define the biological targets chemicals may interact with to disrupt thyroid hormone signaling and the stages in develo...
Ecotoxicology in the 21st century - AOPs, HTT and other acronyms (PRESENTATION)
Product Description:The Duluth Water Quality Lab, which is now the US EPA Mid-Continent Ecology Division, commenced operation in 1967. This presentation is one in a series that focuses on the national and international impacts of this division and its research over its 50-year hi...
Adverse outcome pathway networks: Development, analytics, and applications (PRESENTATION)
Product Description:The US EPA is developing more cost effective and efficient ways to evaluate chemical safety using high throughput and computationally based testing strategies. An important component of this approach is the ability to translate chemical effects on fundamental ...
Assessment of differences in sensitivity to aromatase inhibitors among freshwater fish species (PRESENTATION)
There is significant concern regarding potential impairment of fish reproduction associated with exposure to endocrine disrupting chemicals (EDCs). Aromatase is a steroidogenic enzyme involved in the conversion of androgens to estrogens. Inhibition of aromatase can reduce levels ...
US EPA bioeffects monitoring under the Great Lakes Restoration Initiative: Overview of efforts to assess the biological impacts of CECs (PRESENTATION)
Product Description:Concern exists regarding the potential biological effects of contaminants of emerging concern (CECs) in the Great Lakes. CECs arise from multiple sources, including agriculture, wastewater effluents, and urban nonpoint sources. The Great Lakes Restoration Init...
Empirical testing AOP network-based hazard prediction combined effect of aromatase inhibition & androgen receptor agonism (PRESENTATION)
Adverse outcome pathways (AOPs) describe linkages between a specific molecular perturbation resulting from interaction of a chemical with a biomolecule in an organism and one possible adverse outcome of regulatory significance. While individual AOPs have utility, it is recognized...
Structure-based Understanding of Binding Affinity and Mode of Estrogen Receptor α Agonists and Antagonists. (JOURNAL)
The flexible hydrophobic ligand binding pocket (LBP) of estrogen receptor α (ERα) allows the binding of a wide variety of endocrine disruptors. Upon ligand binding, the LBP reshapes around the contours of the ligand and stabilizes the complex by complementary hydropho...
Consensus models to predict endocrine disruption for all human-exposure chemicals (AAAS Annual Meeting) (PRESENTATION)
Humans are potentially exposed to tens of thousands of man-made chemicals in the environment. It is well known that some environmental chemicals mimic natural hormones and thus have the potential to be endocrine disruptors. Most of these environmental chemicals have never been te...
Structure-Based Understanding of Binding Affinity and Mode of Estrogen Receptor α Agonists and Antagonists (PRESENTATION)
The flexible hydrophobic ligand binding pocket (LBP) of estrogen receptor α (ERα) allows the binding of a wide variety of endocrine disruptors. Upon ligand binding, the LBP reshapes around the contours of the ligand and stabilizes the complex by complementary hydrophobic interact...
Application of Adverse Outcome Pathways (AOPs) in Human Health and Ecotoxicology Capturing Divergent Consequences of Conserved Molecular Initiating Events via AOP Networks (Presentation) (PRESENTATION)
The adverse outcome pathway (AOP) framework was developed to help organize and disseminate existing knowledge concerning the means through which specific perturbations of biological pathways can lead to adverse outcomes considered relevant to risk-based regulatory decision-making...
Developing confidence in adverse outcome pathway-based toxicity predictions effects of the fungicide imazalil on fathead minnow reproduction (Poster) (PRESENTATION)
An adverse outcome pathway (AOP) description linking inhibition of aromatase (cytochrome P450 [cyp] 19) to reproductive dysfunction was reviewed for scientific and technical quality and endorsed by the OECD. An intended application of the AOP framework is to support the use of me...
Cross-species assay validation using the AOP “deiodinase inhibition leading to impaired posterior chamber inflation” (PRESENTATION)
High throughput screening assays able to detect chemical interactions with specific biological targets are increasingly being used to identify chemicals that could be hazardous to humans or wildlife. Most of these assays examine interaction with mammalian proteins. The present wo...
Developing confidence in adverse outcome pathway-based toxicity predictions effects of the fungicide imazalil on fathead minnow reproduction (PRESENTATION)
An adverse outcome pathway (AOP) description linking inhibition of aromatase (cytochrome P450 [cyp] 19) to reproductive dysfunction was reviewed for scientific and technical quality and endorsed by the OECD (https://aopwiki.org/wiki/index.php/Aop:25). An intended application of t...
Application of adverse outcome pathways (AOPs) in human health and ecotoxicology capturing divergent consequences of conserved molecular initiating events via AOP networks (PRESENTATION)
The adverse outcome pathway (AOP) framework was developed to help organize and disseminate existing knowledge concerning the means through which specific perturbations of biological pathways can lead to adverse outcomes considered relevant to risk-based regulatory decision-making...
Application of Computational and High-Throughput in vitro screening for prioritization (Beijing, China, RCES, CAS talk) (PRESENTATION)
Abstract: There are tens of thousands of man-made chemicals to which humans are exposed, but only a fraction of these have the extensive in vivo toxicity data used in most traditional risk assessments. This lack of data, coupled with concerns about testing costs and animal use, a...
Derivation and evaluation of putative adverse outcome pathways for the effects of cyclooxygenase inhibitors on reproductive processes in female fish (JOURNAL)
Cyclooxygenase (COX) inhibition is of concern in fish because COX inhibitors (e.g., ibuprofen) are ubiquitous in aquatic systems/fish tissues, and can disrupt synthesis of prostaglandins that modulate a variety of essential biological functions including reproduction. High conten...
Application of computational and high-throughput in vitro screening for prioritization (ECHA workshop) (PRESENTATION)
Abstract: There are tens of thousands of man-made chemicals to which humans are exposed, but only a fraction of these have the extensive in vivo toxicity data used in most traditional risk assessments. This lack of data, coupled with concerns about testing costs and animal use, a...