Related Topics: Health Research

Health Research Products in the Science Inventory

Records 1 to 25 of 230

Development of a Thyroid Neurovascular Unit Organotypic Systems Model (PRESENTATION)
Abstract for poster presentation
Development of a Methodology to Guide the Replacement of Agency Default Uncertainty Factors with Those Based on Data ()
The Agency's guidance for the derivation of RfD and RfC values call for the downward adjustment of exposure-response levels observed in animals and/or humans to account for the potentially greater sensitivity of humans as compared to test animals (UFA) and the differential sensit...
Children's Health and the Environment: Public Health Issues and Challenges for Risk Assessment (JOURNAL)
Infants and children are not little adults. They are uniquely vulnerable to environmental toxicants. To protect infants and children against toxicants, the National Research Council in 1993 called for development of an approach to risk assessment that considers children's unique...
Epigenetics and the Developmental Origins of Health and Disease (BOOK CHAPTER)
Epigenetic programming is likely to be an important mechanism underlying the lasting influence of the developmental environment on lifelong health, a concept known as the Developmental Origins of Health and Disease (DOHaD). DNA methylation, posttranslational histone protein modif...
Development of a Human Neurovascular Unit Organotypic Systems Model of Early Brain Development (PRESENTATION)
The inability to model human brain and blood-brain barrier development in vitro poses a major challenge in studies of how chemicals impact early neurogenic periods. During human development, disruption of thyroid hormone (TH) signaling is related to adverse morphological effects ...
Development of a Neurovascular Unit Organotypic Systems Model (PRESENTATION)
Abstract for poster presentation, poster and powerpoint presentation
Exposure Factors Handbook Chapter 5 (Update): Soil and Dust Ingestion (PUBLISHED REPORT)
This update includes new information on soil and dust ingestion that has become available since the <em>Exposure Factors Handbook: 2011 Edition</em> was released. The recommended values have also been revised, as needed, to reflect the new information. This chapter explains the ...
2013 NIEHS/EPA Children's Centers Annual Meeting: Protecting Children's Health for a Lifetime (EPA PUBLISHED PROCEEDINGS)
This report includes proceedings from the 2013 NIEHS/EPA Children's Centers Annual Meeting, held in Washington D.C. in October, 2013. Summaries of presentations, speaker biosketches, poster abstracts, and a meeting participant list are all included.
Children’s Lead Exposure: A Multimedia Modeling Analysis to Guide Public Health Decision-Making (JOURNAL)
BACKGROUND: Drinking water and other sources for lead are the subject of public health concerns around the Flint, Michigan, drinking water and East Chicago, Indiana, lead in soil crises. In 2015, the U.S. Environmental Protection Agency (EPA)’s National Drinking Water Advisory C...
NIEHS/EPA Children's Environmental Health and Disease Prevention Research Centers: 2017 Annual Meeting Proceedings (EPA PUBLISHED PROCEEDINGS)
The 2017 Annual Meeting of the NIEHS/EPA Children&rsquo;s Environmental Health and Disease Prevention Research Centers was hosted by EPA in collaboration with NIEHS and the Pediatric Environmental Health Specialty Units (PEHSUs). The meeting was held at the EPA Region 9 offices i...
Children's Environmental Health and Disease Prevention Research Centers Impact Report: Advances in protecting children's health where they live, learn, and play (PUBLISHED REPORT)
In 1997, EPA and the National Institute of Environmental Health Sciences (NIEHS) partnered to form the Children's Environmental Health and Disease Prevention Research Centers. This impact report summarizes the history of the program, scientific findings since the program's incept...
Programming microphysiological systems for children's health protection (SEBM meeting) (PRESENTATION)
Presentation: Programming microphysiological systems for children’s health protectionAuthors: Knudsen1 T, Klieforth2 B, and Slikker3 W Jr.1National Center for Computational Toxicology/EPA, Research Triangle Park NC2National Center for Environmental Research/EPA, Washington DC3Nat...
Latent carcinogenicity of early-life exposure to dichloroacetic acid in mice (JOURNAL)
AbstractEnvironmental exposures occurring early in life may have an important influence on cancer risk later in life. Here we investigated carryover effects of young-adult exposure to dichloroacetic acid (DCA), a small molecule analog of pyruvate and low-level environmental cont...
Neurodevelopmental malformations of the cerebellar vermis in genetically engineered rats (JOURNAL)
The cerebellar vermis is particularly vulnerable to neurodevelopmental malformations in humans and rodents. Sprague-Dawley, and Long-Evans rats exhibit spontaneous cerebellar malformations consisting of heterotopic neurons and glia in the molecular layer of the vermis. Malformati...
Review of Non-Chemical Stressors from the Social Environment (PRESENTATION)
Non-chemical stressors (e.g., noise, diet, temperature, overcrowding) are found in the built, natural and social environments. Correlations between exposure to non-chemical stressors in the social environment (e.g., SES, exposure to violence, acculturation) and negative health ou...
Air Pollutants and Ecological Conditions Around Schools on Tribal Lands (PRESENTATION)
Children are more vulnerable to exposures from their everyday environments compared to adults. Children from Tribal communities have a greater burden of adverse health and well-being outcomes versus children from other communities in the U.S. (US DHHS 2016). Stressors from chi...
Phthalates and metabolic syndrome in U.S. Adolescents (NHANES 2003-2010) (PRESENTATION)
Children’s health outcomes may result from interactions among chemical and non-chemical stressors. We use NHANES data to investigate: Association between phthalate metabolite concentrations and MetS in adolescents If associations vary by family income (a non-chemical stressor)
Examination of U.S. Puberty Timing Data from 1940 to 1994 for Secular Trends: Panel Findings (JOURNAL)
Five articles based on "The Role of Environmental Factors on the Onset and Progression of Puberty" expert panel workshop findings were published as a Supplement to Pediatrics on Feb. 1, 2008. This workshop, sponsored by EPA, NIEHS, and Serono International and held in November o...
Non-Chemical Stressors in a Child’s Social Environment (PRESENTATION)
Non-chemical stressors exist in the built, natural and social environments including physical factors (e.g., noise, temperature and humidity) and psychosocial factors (e.g., poor diet, smoking, illicit drug use)[1]. Scientists study how non-chemical stressors (e.g., social suppor...
A Framework for Assessing Health Risk of Environmental Exposures to Children (Final) (PUBLISHED REPORT)
EPA released the final report entitled, <i>A Framework for Assessing Health Risk of Environmental Exposures to Children</i>, which examines the impact of potential exposures during developmental lifestages and subsequent lifestages, while emphasizing the iterative nature of the a...
Thyroid Hormone-Dependent Formation of a Subcortical Band Heterotopia (SBH) in the Neonatal Brain is not Exacerbated Under Conditions of Low Dietary Iron (PRESENTATION)
Thyroid hormones (TH) are critical for brain development. Modest TH insufficiency in pregnant rats induced by propylthiouracil (PTU) results in formation of a structural abnormality, a subcortical band heterotopia (SBH), in brains of offspring. PTU reduces TH by inhibiting the s...
Structural Abnormalities and Learning Impairments Induced by Low Level Thyroid Hormone Insufficiency: A Cross-Fostering Study (PRESENTATION)
Severe reductions in thyroid hormones (TH) during development alter brain structure and impair learning. Uncertainty surrounds both the impact oflower levels of TH disruption and the sensitivity of available metrics to detect neurodevelopmental deficits of this disruption. We ha...
Thyroid Hormone Disruption Effects Lamination of the Neocortex but not the Cerebellum in a Model of Developmental Hypothyroidism and Hypothyroxinemia (PRESENTATION)
Introduction: Research on neurodevelopmental changes resulting from thyroid hormone (TH) disruption has important basic and clinical implications. We previously demonstrated, in a rodent model, that developmental hypothyroidism or hypothyroxinemia can cause ...
Developmental Hypothyroidism Reduces the Expression of Activity-Dependent Plasticity Genes in Denate Gyrus of the Adult Following Long Term Potentiation (PRESENTATION)
Disruption of thyroid hormone (TH) is a known effect of environmental contaminants. Neurotrophins including brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) have been implicated in brain dysfunction resulting from severe developmental TH insufficiency. Neuro...
Evaluating stressors and their influences on ecological conditions and American Indian children's health and well-being (PRESENTATION)
American Indian children's health and well-being, exposure to stressors from the built, natural, and social environment.