Related Topics: Health Research

Health Research Products in the Science Inventory

Records 1 to 25 of 115

Programming microphysiological systems for children's health protection (SEBM meeting) (PRESENTATION)
Presentation: Programming microphysiological systems for children’s health protectionAuthors: Knudsen1 T, Klieforth2 B, and Slikker3 W Jr.1National Center for Computational Toxicology/EPA, Research Triangle Park NC2National Center for Environmental Research/EPA, Washington DC3Nat...
Latent carcinogenicity of early-life exposure to dichloroacetic acid in mice (JOURNAL)
AbstractEnvironmental exposures occurring early in life may have an important influence on cancer risk later in life. Here we investigated carryover effects of young-adult exposure to dichloroacetic acid (DCA), a small molecule analog of pyruvate and low-level environmental cont...
Neurodevelopmental malformations of the cerebellar vermis in genetically engineered rats (JOURNAL)
The cerebellar vermis is particularly vulnerable to neurodevelopmental malformations in humans and rodents. Sprague-Dawley, and Long-Evans rats exhibit spontaneous cerebellar malformations consisting of heterotopic neurons and glia in the molecular layer of the vermis. Malformati...
Children’s Lead Exposure: A Multimedia Modeling Analysis to Guide Public Health Decision-Making (JOURNAL)
BACKGROUND: Drinking water and other sources for lead are the subject of public health concerns around the Flint, Michigan, drinking water and East Chicago, Indiana, lead in soil crises. In 2015, the U.S. Environmental Protection Agency (EPA)’s National Drinking Water Advis...
Review of Non-Chemical Stressors from the Social Environment (PRESENTATION)
Non-chemical stressors (e.g., noise, diet, temperature, overcrowding) are found in the built, natural and social environments. Correlations between exposure to non-chemical stressors in the social environment (e.g., SES, exposure to violence, acculturation) and negative health ou...
Air Pollutants and Ecological Conditions Around Schools on Tribal Lands (PRESENTATION)
Children are more vulnerable to exposures from their everyday environments compared to adults. Children from Tribal communities have a greater burden of adverse health and well-being outcomes versus children from other communities in the U.S. (US DHHS 2016). Stressors from chi...
Phthalates and metabolic syndrome in U.S. Adolescents (NHANES 2003-2010) (PRESENTATION)
Children’s health outcomes may result from interactions among chemical and non-chemical stressors. We use NHANES data to investigate: Association between phthalate metabolite concentrations and MetS in adolescents If associations vary by family income (a non-chemical stressor)
Examination of U.S. Puberty Timing Data from 1940 to 1994 for Secular Trends: Panel Findings (JOURNAL)
Five articles based on "The Role of Environmental Factors on the Onset and Progression of Puberty" expert panel workshop findings were published as a Supplement to Pediatrics on Feb. 1, 2008. This workshop, sponsored by EPA, NIEHS, and Serono International and held in November o...
Non-Chemical Stressors in a Child’s Social Environment (PRESENTATION)
Non-chemical stressors exist in the built, natural and social environments including physical factors (e.g., noise, temperature and humidity) and psychosocial factors (e.g., poor diet, smoking, illicit drug use)[1]. Scientists study how non-chemical stressors (e.g., social suppor...
A Framework for Assessing Health Risk of Environmental Exposures to Children (Final) (PUBLISHED REPORT)
EPA released the final report entitled, <i>A Framework for Assessing Health Risk of Environmental Exposures to Children</i>, which examines the impact of potential exposures during developmental lifestages and subsequent lifestages, while emphasizing the iterative nature of the a...
Thyroid Hormone-Dependent Formation of a Subcortical Band Heterotopia (SBH) in the Neonatal Brain is not Exacerbated Under Conditions of Low Dietary Iron (PRESENTATION)
Thyroid hormones (TH) are critical for brain development. Modest TH insufficiency in pregnant rats induced by propylthiouracil (PTU) results in formation of a structural abnormality, a subcortical band heterotopia (SBH), in brains of offspring. PTU reduces TH by inhibiting the s...
Structural Abnormalities and Learning Impairments Induced by Low Level Thyroid Hormone Insufficiency: A Cross-Fostering Study (PRESENTATION)
Severe reductions in thyroid hormones (TH) during development alter brain structure and impair learning. Uncertainty surrounds both the impact oflower levels of TH disruption and the sensitivity of available metrics to detect neurodevelopmental deficits of this disruption. We ha...
Thyroid Hormone Disruption Effects Lamination of the Neocortex but not the Cerebellum in a Model of Developmental Hypothyroidism and Hypothyroxinemia (PRESENTATION)
Introduction: Research on neurodevelopmental changes resulting from thyroid hormone (TH) disruption has important basic and clinical implications. We previously demonstrated, in a rodent model, that developmental hypothyroidism or hypothyroxinemia can cause ...
Developmental Hypothyroidism Reduces the Expression of Activity-Dependent Plasticity Genes in Denate Gyrus of the Adult Following Long Term Potentiation (PRESENTATION)
Disruption of thyroid hormone (TH) is a known effect of environmental contaminants. Neurotrophins including brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) have been implicated in brain dysfunction resulting from severe developmental TH insufficiency. Neuro...
Evaluating stressors and their influences on ecological conditions and American Indian children's health and well-being (PRESENTATION)
American Indian children's health and well-being, exposure to stressors from the built, natural, and social environment.
The Influence of Declining Air Lead Levels on Blood Lead-Air Lead Slope Factors in Children (JOURNAL)
This presentation describes calculation of blood lead-air lead slope factor within an analysis of the relationship between blood lead levels and air lead levels among participants in the National Health and Nutrition Examination Survey (NHANES). The slope factors are compared wi...
Polybrominated Diphenyl Ether (DE-71)Interferes with Thyroid Hormone Action Independent Of Effects On Circulating Levels of Thyroid Hormone in Male Rats (JOURNAL)
Polybrominated diphenyl ethers (PBDEs) are routinely found in human tissues including cord blood and breast milk. PBDEs may interfere with thyroid hormone (TH) during development, which could produce neurobehavioral deficits. An assumption in experimental and epidemiological stud...
Improving the Risk Assessment of Persistent, Bioaccumulative, and Toxic (PBT) Chemicals in Breast Milk: Workshop Summary Report (PUBLISHED REPORT)
This report provides a summary of discussions held at an EPA-sponsored workshop in Research Triangle Park, NC in October, 2012. Workshop participants discussed approaches to improve risk assessment of PBT chemicals in breast milk, data gaps, uncertainties, and suggested solutions...
Reproductive Toxicology: From Science to Public Policy (PRESENTATION)
Male reproductive toxicology research substantially influences policies that protect men's health. US policy directs regulatory agencies to ensure environmental protection for vulnerable groups, including boys and men where factors like age- and sex-specific sensitivities are app...
Linking Early Life Stages: The First Step towards Lifecourse Risk Assessment (PRESENTATION)
The abstract is the overview of a workshop proposed for inclusion in 2015 Society of Toxicology annual meeting program. The workshop will introduce the audience to lifecourse theory and speakers will provide examples of using PBPK models to link exposures and outcomes resulting ...
INFLUENCES OF ASTHMA AND HOUSEHOLD ENVIRONMENT ON LUNG FUNCTION OF CHILDREN AND ADOLESCENTS: THE THIRD NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY (JOURNAL)
We examined influences of asthma and household environment (passive smoking, gas stove use, and having a dog or cat), on seven measures of spirometric lung function in 8-16 yearold subjects, as measured in the Third National Health and Nutrition Examination Survey (NHANES III). ...
WHAT'S SO SPECIAL ABOUT THE DEVELOPING IMMUNE SYSTEM? (Journal Article) (JOURNAL)
The evolution of the subdiscipline of developmental immunotoxicology (DIT) as it exists today has been shaped by significant regulatory pressures as well as key scientific advances. This review considers the role played by legislation to protect children’s health, and on the eme...
INTERNATIONAL CHILDHOOD CANCER COHORT CONSORTIUM (Journal Article) (JOURNAL)
Childhood cancers are rare conditions whose etiology is poorly understood. There is evidence that for some, the causal pathway may commence in utero or during peri-conception. One traditional epidemiologic approach to the study of rare diseases is the use of a retrospective cas...
Impacts of green space and tree cover on birth outcomes in Durham-Chapel Hill, NC (PRESENTATION)
Ecosystem services affect human health through a variety of mechanisms. We investigated associations between green space and tree cover, and birth weight (BWT), pre-term birth (PTB), and low birth weight (LBW). Births in and around Durham-Chapel Hill, NC, between 1 January 2004 ...
A Risk-based Prioritization Strategy for Thyroid Disruption Under EDSP21 (PRESENTATION)
The US Environmental Protection Agency (EPA) established the Endocrine Disruptor Screening Program (EDSP) to determine whether certain substances may have an effect in humans or wildlife that disrupt the estrogen, androgen or thyroid axes. The EDSP is now utilizing comp...