Related Topics: Health Research

Health Research Products in the Science Inventory

Records 1 to 25 of 719

Estimating Asthma, Myocardial Infarction, and Heart Failure Hospitalizations and Emergency Room Visits in New York City from Exposure to Ambient Fine Particulate Matter using a Hierarchical Bayesian Model Approach (PRESENTATION)
Fine particulate matter has been shown to influence the frequency and severity of respiratory and cardiovascular diseases, and also increases inflammatory proteins and heart rate variability (HRV). A novel approach was developed to reduce the spatial and temporal gaps in the ambi...
Disrupting the immune system by diesel pollution (PRESENTATION)
For 25 years, clinical, animal and epidemiological studies have shown associations between diesel exhaust and allergic disease. Diesel particles have the potential to increase allergic symptoms, increase cellular inflammation enhance allergic antibodies and prime allergic sensit...
Carbon dioxide challenge enhances the sensitivity of whole body plethysmography (WBP) measurements of lung growth and ozone-induced changes in juvenile Long-Evans rats. (PRESENTATION)
Background. Risk factors associated with development of childhood disorders such as asthma and obesity include prematurity and intrauterine growth restriction. We recently demonstrated that exposure of Long Evans rats in early pregnancy to the air pollutant, ozone, resulted in re...
Differential Effects of Wildfire Biomass Smoke Inhalation on Allergic Inflammation in Mice (PRESENTATION)
Wildland fires emit high concentrations of airborne particulate matter (PM) and volatile organic compounds which can impact sensitive populations such as asthmatics. Health effects of these biomass emissions may vary significantly depending on fuel type and burn conditions. We as...
Long Acting β2 Adrenergic Potentiates Ozone-Induced Lung Injury and Inflammation (PRESENTATION)
Ozone (O3), a ubiquitous air pollutant, disproportionately affects asthmatics. We have shown that O3-induced lung injury and inflammation are associated with increased circulating epinephrine and corticosterone, and inhibiting β adrenergic receptors (AR) and glucocor...
A Historical Perspective on the Dichotomy of Arsenic as a Poison and Medicinal Agent (PRESENTATION)
Arsenic is one of the most interesting and enigmatic elements of the periodic table. Its use as an intentional poison has been known for centuries and occasionally occurs today. Arsenic has been called the “King of Poisons”, because it had been used to poison royalt...
Environmental Public Health Indicators Impact Report: Data and methods that support environmental public health decision-making by communities (PUBLISHED REPORT)
This report presents the results of twenty competitively funded Science-To-Achieve-Results (STAR) grants in EPA's Environmental Public Health Indicators (EPHI) research program. The grantsdirectly supported health interventions, informed policy and decision-making, and improved t...
A Collaborative Effort to Assess Environmental Health in Newport News, Virginia (PUBLISHED REPORT)
The Region 3 “Making a Visible Difference in Communities” (MVD) initiative for Southeast Newport News, VA has taken a community-centric, place-based approach to identifying and delivering service to the area’s residents and the city as a whole. Beginning with a CARE (Community Ac...
Community vulnerability to health impacts of wildland fire smoke exposure (JOURNAL)
Identifying communities vulnerable to adverse health effects from exposure to wildfire smoke may help prepare responses, increase the resilience to smoke and improve public health outcomes during smoke days. We developed a Community Health-Vulnerability Index (CHVI) based on fact...
Presence of pharmaceuticals in fish collected from urban rivers in the U.S. EPA 2008–2009 National Rivers and Streams Assessment (JOURNAL)
Fish are good indicators of aquatic environment pollution because of their capability to uptake pollutants contained in water. Therefore, accumulation of pharmaceutical compounds in freshwater and marine fish and other aquatic organisms has been studied extensively in the last de...
Active vs. sedentary lifestyle from weaning to adulthood and susceptibility to ozone in rats (JOURNAL)
This is publication for a peer review journal.
Air pollution exposure modeling of individuals (PRESENTATION)
Air pollution epidemiology studies of ambient fine particulate matter (PM2.5) often use outdoor concentrations as exposure surrogates. These surrogates can induce exposure error since they do not account for (1) time spent indoors with ambient PM2.5 levels attenuated from outdoor...
A Proof-of-Concept Approach for Quantifying Multi-Pollutant Health Impacts Using the Open-Source BenMAP-CE Software Program (PRESENTATION)
Background Air pollution risk assessments often employ effect coefficients from epidemiologic studies to quantify the public health impact of changes in air quality. Partly due to data and methodological limitations, epidemiologic studies have traditionally characterized the heal...
Air Pollution Exposure Modeling for Epidemiology Studies and Public Health (PRESENTATION)
Air pollution epidemiology studies of ambient fine particulate matter (PM2.5) often use outdoor concentrations as exposure surrogates. These surrogates can induce exposure error since they do not account for (1) time spent indoors with ambient PM2.5 levels attenuated from outdoor...
Exhaled breath aerosol (EBA): the simplest non-invasive medium for public health and occupational exposure biomonitoring (JOURNAL)
Blood, breath and urine represent the three primary diagnostic fluids for assessing environmental exposures and human health state. Although there is overlap in biological media choice for many applications, each have their individual strategic and analytical advantages: Blood is...
Integrated Science Assessment (ISA) for Sulfur Oxides – Health Criteria (Final) (ASSESSMENT DOCUMENT)
The SOx ISA reviews information on atmospheric science, exposure, dosimetry, mode of action, and health effects related to sulfur oxides and sulfur dioxide (SO2), including evidence from controlled human exposure, epidemiologic, and toxicological studies.
DATA COLLECTION ON ENVIRONMENTAL MANAGEMENT OF ASTHMA ()
We are working with CDC to determine if we can add a module to one or more of their surveys which would provide information on awareness of and existing attitudes toward asthma and its environmental triggers, actions implemented and barriers to implementation encountered by adult...
Impacts of oak pollen on allergic asthma in the United States and potential influence of future climate change (JOURNAL)
Oak pollen season length for moderate (RCP4.5) and severe climate change scenarios (RCP8.5) are estimated through 2090 using five climate models and published relationships between temperature, precipitation, and oak pollen season length. We calculated asthma ED visit counts asso...
Lung Function Changes in Mice Sensitized to Ammonium Hexachloroplatinate (JOURNAL)
Occupational exposure to halogenated platinum salts can trigger the development of asthma. The risk to the general population that may result from the use of platinum in catalytic converters and its emerging use as a diesel fuel additive is unclear. To investigate pulmonary respo...
Differential Effects of Particulate Matter Upwind and Downwind of an Urban Freeway in an Allergic Mouse Model (JOURNAL)
Near-road exposure to air pollutants has been associated with decreased lung function and other adverse health effects in susceptible populations. This study was designed to investigate whether different types of near-road particulate matter (PM) contribute to exacerbation of all...
Epigenetic Regulation of Newborns' Imprinted Genes Related to Gestational Growth: Patterning by Parental Race/Ethnicity and Maternal Socioeconomic Status (JOURNAL)
BACKGROUND: Children born to parents with lower income and education are at risk for obesity and later-life risk of common chronic diseases, and epigenetics has been hypothesised to link these associations. However, epigenetic targets are unknown. We focus on a cluster of well­ c...
Asthma as a disruption in iron homeostasis (JOURNAL)
Over several decades, asthma has evolved from being recognized as a single disease to include a diverse group of phenotypes with dissimilar natural histories, pathophysiologies, responses to treatment, and distinctive molecular pathways. With the application of Occam’s razor to ...
Data-driven asthma endotypes defined from blood biomarker and gene expression data (JOURNAL)
The diagnosis and treatment of childhood asthma is complicated by its mechanistically distinct subtypes (endotypes) driven by genetic susceptibility and modulating environmental factors. Clinical biomarkers and blood gene expression were collected from a stratified, cross-section...
Soy Biodiesel Emissions Have Reduced Inflammatory Effects Compared to Diesel Emissions in Healthy and Allergic Mice (JOURNAL)
Toxicity of exhaust from combustion of petroleum diesel (BO), soy-based biodiesel (B100), or a 20% biodiesel/80% petrodiesel mix (B20) was compared in healthy and house dust mite (HDM)-allergic mice. Fuel emissions were diluted to target fine particulate matter (PM2.5) conrentrat...
Factors associated with self-reported health: implications for screening level community-based health and environmental studies (JOURNAL)
BACKGROUND: Advocates for environmental justice, local, state, and national public health officials, exposure scientists, need broad-based heath indices to identify vulnerable communities. Longitudinal studies show that perception of current health status predicts subsequent mort...