EPA Science Inventory

Products in the Science Inventory

Records 1 to 25 of 241

Computational Model of Secondary Palate Fusion and Disruption (JOURNAL)
Morphogenetic events are driven by cell-generated physical forces and complex cellular dynamics. To improve our capacity to predict developmental effects from cellular alterations, we built a multi-cellular agent-based model in CompuCell3D that recapitulates the cellular networks...
Toxicogenomic assessment of 6-OH-BDE47 induced developmental toxicity in chicken embryo (JOURNAL)
Hydroxylated and methoxylated polybrominated diphenyl ethers (OH-/MeO-PBDEs) are analogs of PBDEs with hundreds of possible structures and many of them can activate aryl hydrocarbon receptor (AhR), however, the in vivo evidence on the toxicity of OH-/MeO-PBDEs are still very limi...
Chlorinated Dioxins and Furans from Kelp and Copper Sulfate: Initial Investigations of Dioxin Formation in Mineral Feed Supplements (Journal Article) (JOURNAL)
In 2002, dioxins were discovered in animal feed ingredients during a random sampling by Irish officials and subsequently traced to particular mineral supplements produced at a Minnesota plant in the United States. These products sold under the names of SQM Mineral Products and C...
Exposure and Human Health Evaluation of Airborne Pollution from the World Trade Center Disaster (JOURNAL)
In the days following the September 11, 2001, terrorist attack on New York City's World Trade Center (WTC) towers, many Federal agencies, including the U.S. Environmental Protection Agency (EPA), were called upon to bring their technical and scientific expertise to the national e...
Genetic basis for rapidly evolved tolerance in the wild: adaptation to toxic pollutants by an estuarine fish species (JOURNAL)
Atlantic killifish (Fundulus heteroclitus) residing in some urban and industrialized estuaries of the US eastern seaboard demonstrate recently evolved and extreme tolerance to toxic aryl hydrocarbon pollutants, characterized as dioxin-like compounds (DLCs). Here we provide an unu...
The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish (JOURNAL)
Atlantic killifish populations have rapidly adapted to normally lethal levels of pollution in four urban estuaries. Through analysis of 384 whole killifish genome sequences and comparative transcriptomics in four pairs of sensitive and tolerant populations, we identify the aryl h...
Integrating Monitoring and Genetic Methods To Infer Historical Risks of PCBs and DDE to Common and Roseate Terns Nesting Near the New Bedford Harbor Superfund Site (Massachusetts, USA) (JOURNAL)
Common and roseate terns are migratory piscivorous seabirds with major breeding colonies within feeding range of thepolychlorinated biphenyl (PCB)-contaminated New Bedford Harbor (NBH, MA, USA) Superfund site. Our longitudinal study shows that before PCB discharges into NBH cease...
Characterization of the Particulate Emissions from the BP Deepwater Horizon Surface Oil Burns (JOURNAL)
Opportunistic particle samples were gathered from the sail of a tethered aerostat during at-sea plume sampling of the purposely-burned surface oil during the BP Deepwater Horizon disaster in the Gulf of Mexico. Particles were analyzed for polycyclic aromatic hydrocarbons (PAHs),...
Susceptibility based upon Chemical Interaction with Disease Processes: Potential Implications for Risk Assessment (JOURNAL)
One of the challenges facing toxicology and risk assessment is that numerous host and environmental factors may modulate vulnerability and risk. An area of increasing interest is the potential for chemicals to interact with background aging and disease processes, an interaction...
Evaluation of the Association between Persistent Organic Pollutants (POPs)and Diabetes in Epidemiological Studies: A National Toxicology Program Workshop Review (JOURNAL)
Background: Diabetes is a major threat to public health in the United States and worldwide. Understanding the role of environmental chemicals in the development or progression of diabetes is an emerging issue in environmental health.Objective: We assessed the epidemiologic litera...
Targeted Approach to Identify Genetic Loci Associated with Evolved Dioxin Tolerance in Atlantic Killifish (Fundulus heteroclitus) (JOURNAL)
Extreme tolerance to highly toxic dioxin-like contaminants (DLCs) has evolved independently and contemporaneously in (at least) four populations of Atlantic killifish (Fundulus heteroclitus). Surprisingly, the magnitude and phenotype of DLC tolerance is similar among these killi...
Journal Article: Infant Exposure to Dioxin-Like Compounds in Breast Milk (JOURNAL)
A simple, one-compartment, first-order pharmacokinetic model is used to predict the infant body burden of dioxin-like compounds that results from breast-feeding. Validation testing of the model showed a good match between predictions and measurements of dioxin toxic equivalents ...
Pentachlorophenol and cancer risk: Focusing the lens on specific chlorophenols and contaminants (JOURNAL)
Objective: Pentachlorophenol is a fungicide widely used as a wood preservative, classified in 1999 by the International Agency for Research on Cancer as a “possible human carcinogen”. We review currently available epidemiological research to determine the extent to which recent...
A TIME-TRENDS STUDY OF THE OCCURRENCES AND LEVELS OF CDDS, CDFS AND DIOXIN-LIKE PCBS IN SEDIMENT CORES FROM 11 GEOGRAPHICALLY DISTRIBUTED LAKES IN THE U.S. (JOURNAL)
Polychlorinated dibenzo-p-dioxins (CDDs), polychlorinated dibenzofurans (CDFs) and certain non- and mono-ortho substituted polychlorinated biphenyls (cp-PCBs) are a general class of chlorinated aromatic compounds that are considered as dioxin-like. Because these chemicals are hi...
TRENDS IN DIOXIN AND PCB CONCENTRATIONS IN MEAT SAMPLES FROM SEVERAL DECADES OF THE 20TH CENTURY (JOURNAL)
Data from several studies suggest that concentrations of dioxins rose in the environment from the 1930s to about the 1960s/70s and have been declining over the last decade or two. The most direct evidence of this trend is lake core sediments, with some other evidence from older...
U.S. EPA's National Dioxin Air Monitoring Network: Analytical Issues (JOURNAL)
The U.S. EPA has established a National Dioxin Air Monitoring Network (NDAMN) to determine the temporal and geographical variability of atmospheric chlorinated dibenzo-p-dioxins (CDDs), furans (CDFs), and coplanar polychlorinated biphenyls (PCBs) at rural and non-impacted locatio...
DEVELOPMENT AND VALIDATION OF AN AIR-TO-BEEF FOOD CHAIN MODEL FOR DIOXIN-LIKE COMPOUNDS (JOURNAL)
A model for predicting concentrations of dioxin-like compounds in beef is developed and tested. The key premise of the model is that concentrations of these compounds in air are the source term, or starting point, for estimating beef concentrations. Vapor-phase concentrations t...
BACKGROUND CONTAMINATION BY COPLANAR POLYCHLORINATED BIPHENYLS (PCBS) IN TRACE LEVEL HIGH RESOLUTION GAS CHROMATOGRAPHY/HIGH RESOLUTION MASS SPECTROMETRY (HRGC/HRMS) ANALYTICAL PROCEDURES (JOURNAL)
The addition of the "dioxin-like" polychlorinated biphenyl (PCB) congeners to the assessment of risk associated with the 2,3,7,8-chlorine substituted dioxins and furans has dramatically increased the number of laboratories worldwide that are developing analytical procedures for t...
ASSESSMENT OF DIOXIN INHALATION EXPOSURES AND POTENTIAL HEALTH IMPACTS FOLLOWING THE COLLAPSE OF THE WORLD TRADE CENTER TOWERS (JOURNAL)
In the days following the September 11, 2001, terrorist attack on New York City's World Trade Center (WTC) towers, EPA, other federal agencies, and New York City and New York State public health and environmental authorities initiated numerous air monitoring activities to better ...
ANALYSIS OF ANIMAL- AND PLANT-DERIVED FEED INGREDIENTS FOR DIOXIN-LIKE COMPOUNDS (JOURNAL)
During a national survey of polychlorinated dibenzo-p-dioxins (CDD), dibenzofurans (CDF), and dioxin-like coplanar PCBs (PCB) in poultry, elevated concentrations above 20 parts per trillion (ppt) toxic equivalents (TEQ) were found in the fat of 2 broilers. These TEQ values were ...
AN EVALUATION OF THREE EMPIRICAL AIR-TO-LEAF MODELS FOR POLYCHLORINATED DIBENZO-P-DIOXINS AND DIBENZOFURANS (JOURNAL)
Three empirical air-to-leaf models for estimating grass concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (abbreviated dioxins and furans) from air concentrations of these compounds are described and tested against two field data sets. All are empirical in th...
AN ASSESSMENT OF DIOXIN LEVELS IN PROCESSED BALL CLAY FROM THE U.S. (JOURNAL)
The presence of dioxin-like compounds in ball clay was discovered in 1996 as a result of an investigation to determine the sources of elevated levels of dioxin found in two chicken fat samples from a national survey of poultry. The investigation indicated that soybean meal added...
A STUDY TO EVALUATE THE LEVELS OF DIOXIN-LIKE COMPOUNDS IN DAIRY FEEDS IN THE U.S. (JOURNAL)
The Environmental Protection Agency (EPA), in cooperation with USDA and the US Food and Drug Administration (FDA), has undertaken a program to study the presence of dioxin-like compounds in animal feeds. Two phases of this program have been completed, and this paper reports on t...
A STATISTICAL SURVEY OF DIOXIN-LIKE COMPOUNDS IN U.S. BEEF: A PROGRESS REPORT (JOURNAL)
The USEPA and the USDA completed the first statistically designed survey of the occurrence and concentration of dibenzo-p-dioxins (CDDs), dibenzofurans (CDFs), and coplanar polychlorinated biphenyls (PCBs) in the fat of beef animals raised for human consumption in the United Stat...
A PHARMACOKINETIC MODEL FOR ESTIMATING EXPOSURE OF AMERICANS TO DIOXIN-LIKE COMPOUNDS IN THE PAST, PRESENT, AND FUTURE (JOURNAL)
Empirical evidence suggests that exposure of Americans to dioxin-like compounds was low during the early decades of the 20th century, then increased during the 1940s and 1950s reaching a peak in the 1960s and 1970s, and progressively decreased to lower levels in the 1980s and 199...