Science Inventory

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Druwe, I. AND X. Arzuaga Andino. EPA’s draft IRIS Assessment of PFHxS. Presentation to the external ERG peer review panel. External peer review meeting for the draft PFHxS IRIS assessment, Virtual, DC, February 26 - March 01, 2024.

Druwe, I., T. Anderson, P. Reinhart, R. Shaffer, Suryanarayana Vulimiri, AND L. Dishaw. Implementation of the Key Characteristics to Optimize Mechanistic Evidence Extraction and Organization. Society of Toxicology Annual Meeting, Nashville, TN, March 20 - 23, 2023.

Svendsen, C., P. Whaley, G. Vist, T. Husøy, A. Beronius, I. Druwe, T. Hartung, S. Hoffman, C. Hooijmans, G. Kass, J. Robinson, E. Roggen, A. Rooney, N. Roth, M. Vinken, AND G. Mathisen. Protocol for designing INVITES-IN, a tool for assessing the internal validity of in vitro studies. Evidence-Based Toxicology. Taylor & Francis Group, London, Uk, 1(1):2232415, (2023). https://doi.org/10.1080/2833373X.2023.2232415

Dishaw, L., I. Druwe, R. Shaffer, AND P. Reinhart. Systematic evidence map (SEM) for ethylbenzene: An overview of the evidence base informing developmental, reproductive, and nervous system (DART-NTX) effects. DNTS Annual Meeting, Charleston, SC, June 24 - 28, 2023.

Hoffman, S., E. Aissa, M. Angrish, C. Beausoleil, F. Bois, L. Ciccolallo, P. Craig, R. de Vries, J. Dorne, I. Druwe, S. Edwards, C. Eskes, M. Georgiadis, T. Hartung, A. Kienzler, E. Kristjansson, J. Lam, L. Martino, B. Meek, R. Morgan, I. Munoz-Guajardo, Pamela Noyes, E. Parmelli, A. Piersma, A. Rooney, E. Sena, K. Sullivan, J. Tarazona, A. Terron, K. Thayer, J. Turner, J. Verbeek, D. Verloo, M. Vinken, S. Watford, P. Whaley, D. Wikoff, K. Willett, AND K. Tsaioun. Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks. ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, , 1-20, (2022). https://doi.org/10.14573/altex.2202141

Arzuaga, X., I. Druwe, AND B. Blake. Applying of the key characteristics approach for evidence screening and analysis of benzo[a]pyrene-induced male reproductive toxicity. Society of Toxicology, San Diego, CA, March 27 - 31, 2022.

Wilkins, A., P. Whaley, A. Persad, I. Druwe, J. Lee, MicheleM Taylor, A. Shapiro, N. Blanton, C. Lemeris, AND K. Thayer. Assessing author willingness to enter study information into structured data templates as part of the manuscript submission process: A pilot study. Heliyon. Elsevier B.V., Amsterdam, Netherlands, 8(3):1-9, (2022). https://doi.org/10.1016/j.heliyon.2022.e09095

Blake, B., T. Anderson, X. Arzuaga Andino, AND I. Druwe. Building confidence in mechanistic evidence derived from high throughput assay data in ToxCast to inform hazard evaluation. Systematic Review Community of Practice Meeeting, Durham, NC, July 11, 2023.

Arzuaga, X., B. Blake, AND I. Druwe. Key characteristics approach for evidence screening and analysis of benzo[a]pyrene-induced male reproductive toxicity. EBTC Monthly Webinar: New Developments in Mechanism-Driven Chemical Assessment, NA, DC, August 30, 2022.

Blake, B., I. Druwe, AND X. Arzuaga. Synthesis of mechanistic evidence for male reproductive toxicity of benzo[a]pyrene using the key characteristics approach in concert with the mode of action framework. The Society of Toxicology Annual Meeting, San Diego, CA, March 27 - 31, 2022.

Carlson, L., M. Angrish, A. Shirke, E. Radke-Farabaugh, B. Schulz, A. Kraft, R. Judson, G. Patlewicz, R. Blain, C. Lin, N. Vetter, C. Lemeris, P. Hartman, H. Hubbard, X. Arzuaga, Allen Davis, L. Dishaw, I. Druwe, H. Hollinger, R. Jones, J. Kaiser, L. Lizarraga, Pamela Noyes, MicheleM Taylor, A. Shapiro, A. Williams, AND K. Thayer. Systematic Evidence Map for Over One Hundred and Fifty Per- and Polyfluoroalkyl Substances (PFAS). ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 130(5):1-20, (2022). https://doi.org/10.1289/EHP10343

Devries, R., M. Angrish, P. Brown, J. Brozek, A. Rooney, D. Wikoff, P. Whaley, S. Edwards, R. Morgan, I. Druwe, S. Hoffman, T. Hartung, K. Thayer, M. Avery, B. Beverly, M. Falavigna, C. Gibbons, K. Goyak, A. Kraft, F. Nampo, A. Qaseem, M. Sears, J. Singh, C. Willet, E. Yost, H. Schunneman, AND K. Tsaioun. Applying Evidence-Based Methods to the Development and Use of Adverse Outcome Pathways. ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, , 336-347, (2021). https://doi.org/10.14573/altex.2101211

Arzuaga, X., I. Druwe, AND B. Blake. Applying the Key Characteristics Approach for Evaluation of Toxicological and Mechanistic Evidence on Benzo[a]Pyrene-Induced Male Reproductive Toxicity. Wayne State University - Pharmacology Department Webinar, NA, NA - Webinar, January 29, 2021.

Druwe, I., B. Blake, Allen Davis, J. Dean, C. Gibbons, J. Lambert, L. Lizarraga, AND X. Arzuaga. Applying the Key Characteristics Approach for the Quantitative Evaluation of the Toxicological and Mechanistic Evidence on Benzo[a]Pyrene-Induced Male Reproductive Toxicity. Birth Defects Research and Prevention Annual Meeting (Virtually), NA, Virtual, June 28 - 30, 2021.

Druwe, I., B. Blake, Allen Davis, J. Dean, C. Gibbons, AND L. Lizarraga. Applying the Key Characteristics Approach to Evaluate Mechanistic Evidence for Qualitative and Quantitative Weight of Evidence to Support Risk Assessment: A Case Study with Benzo[a]Pyrene-Induced Male Reproductive Toxicity. Birth Defects Research and Prevention virtual meeting, NA, NC, June 28 - July 01, 2021.

Yost, E., A. Galizia, D. Kapraun, A. Persad, Suryanarayana Vulimiri, M. Angrish, J. Lee, AND I. Druwe. Health Effects of Naphthalene Exposure: A systematic Evidence Map and Analysis of Potential Considerations for Dose-Response Evaluation. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, (076002):1-30, (2021). https://doi.org/10.1289/EHP7381

Blake, B., I. Druwe, AND X. Arzuaga. Implementation of the key characteristics of male reproductive toxicants to synthesize mechanistic evidence: a case study of benzo[a]pyrene. Birth Defects Research and Society Prevention Annual Meeting, NA, Virtual Meeting, June 24 - July 01, 2021.

Blake, B., I. Druwe, AND X. Arzuaga. Implementation of the key characteristics of male reproductive toxicity to synthesize mechanistic evidence: a case study of benzo[a]pyrene. Birth Defects Research and Society Prevention Annual Meeting, NA, June 24 - July 01, 2021.

Arzuaga, X., L. Lizarraga, AND I. Druwe. Introduction to Systematic Review in the Context of Environmental Health Assessments. To be Presented at CompTox Communities of Practice Webinar, Washington, District Of Columbia, May 27, 2021.

Lee, J., Jeff Gift, I. Druwe, AND Allen Davis. Updated Problem Formulation and Protocol for the Inorganic Arsenic (iAs) IRIS Assessment. 8th International Congress and Exhibition on Arsenic in the Environment ( As2021) Virtual meeting, NA, NETHERLANDS, June 07 - 10, 2021.

Kapraun, D., P. Schlosser, L. Nylander-French, D. Kim, E. Yost, AND I. Druwe. A Physiologically Based Pharmacokinetic Model for Naphthalene With Inhalation and Skin Routes of Exposure. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 177(2):377-391, (2020). https://doi.org/10.1093/toxsci/kfaa117

Druwe, I., B. Blake, AND X. Arzuaga. Applying the Key Characteristics Approach for Qualitative and Quantitative Evaluation of the Toxicological and Mechanistic Evidence on Benzo[a]Pyrene-Induced Male Reproductive Toxicity. Society for Risk Analysis, NA, Virtual, December 13 - 17, 2020.

Allen, B., K. Shao, K. Hobbie, W. Mendez Jr, JaniceS Lee, I. Cote, I. Druwe, Jeff Gift, AND Allen Davis. Bayesian Hierarchical Dose-response Meta-analysis of Epidemiological Studies : Modeling and Target Population Prediction Methods. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, Netherlands, 145:106111, (2020). https://doi.org/10.1016/j.envint.2020.106111

Mendez, W., K. Shao, JaniceS Lee, I. Cote, I. Druwe, Allen Davis, AND Jeff Gift. Model Averaging Methods for the Evaluation of Dose-Response Model Uncertainty When Assessing the Suitability of Studies for Estimating Risk. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, Netherlands, 143:105857, (2020). https://doi.org/10.1016/j.envint.2020.105857

Allen, B., K. Shao, K. Hobie, W. Mendez Jr, JaniceS Lee, I. Cote, I. Druwe, Jeff Gift, AND Allen Davis. Systematic dose-response of environmental epidemiologic studies: Dose and Response Pre-Analysis. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, Netherlands, 142:105810, (2020). https://doi.org/10.1016/j.envint.2020.105810