Science Inventory

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CHANG, D., P. P. EGEGHY, J. B. KNAAK, R. TORNERO-VELEZ, M. S. OKINO, F. W. POWER, M. DELLARCO, C. S. MAZUR, J. F. KENNEKE, AND C. C. DARY. INFLUENCE OF MATRIX FORMULATION ON DERMAL PERCUTANEOUS ABSORPTION OF TRIAZOLE FUNGICIDES USING QSAR AND PBPK / PD MODELS. Presented at ISEA/ISEE 2006 , Paris, FRANCE, September 02 - 06, 2006.

OKINO, M. S., C. B. THOMPSON, F. W. POWER, R. TORNERO-VELEZ, A. TSANG, J. N. BLANCATO, AND C. C. DARY. URINARY BIOMARKER INTERPRETATION USING PHARMACOKINETIC MODELS. Presented at International Council of Chemistry Associations Workshop, Minneapolis, MN, July 26 - 27, 2006.

ZHANG, X., M. S. OKINO, FRED W. POWER, J. B. KNAAK, A. M. TSANG, L. S. HARRISON, A. O. RUIZ, C. B. THOMPSON, AND C. C. DARY. USE OF EXPOSURE RELATED DOSE ESTIMATING MODEL ( ERDEM ) TO CONSTRUCT A PBPK /MODEL FOR CARBOFURAN WITH THE REPORTED EXPERIMENTAL DATA IN THE RAT. Presented at Society of Toxicology, San Diego, CA, March 05 - 09, 2006.

KNAAK, J. B., D. CHANG, C. C. DARY, R. TORNERO-VELEZ, M. S. OKINO, AND FRED W. POWER. ESTIMATION OF ADIPOSE TISSUE; BLOOD PARTITION COEFFICIENTS OF CARBAMATES AND ORGANOPHOSPHORUS PESTICIDES USING RELATIVE LIPID CONTENT AND LOGP AS THE MECHANISTIC DETERMINANTS. Presented at American Chemical Society Meeting and Exposition, Washington, DC, August 27 - September 01, 2005.

Nocerino, J M., B A. Schumacher, AND C C. Dary. ROLE OF LABORATORY SAMPLING DEVICES AND LABORATORY SUBSAMPLING METHODS IN OPTIMIZING REPRESENTATIVENESS STRATEGIES. ENVIRONMENTAL FORENSICS. Taylor & Francis, Inc., Philadelphia, PA, 6:35-44, (2005).

OKINO, M. S., W. CHIU, M. V. EVANS, F. W. POWER, J. C. LIPSCOMB, R. TORNERO-VELEZ, C. C. DARY, J. N. BLANCATO, C. CHEN, AND L. S. BIRNBAUM. SUITABILITY OF USING IN VITRO AND COMPUTATIONALLY ESTIMATED PARAMETERS IN SIMPLIFIED PHARMACOKINETIC MODELS. Presented at North American ISSX Meeting , Maui, HI, October 23 - 27, 2005.

OKINO, M. S., F. W. POWER, J. B. KNAAK, R. TORNERO-VELEZ, C. LUNCHICK, A. LOWIT, J. N. BLANCATO, AND C. C. DARY. USE OF A PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL TO ESTIMATE ABSORBED CARBARYL DOSE IN CHILDREN AFTER TURF APPLICATION. Presented at Socieity of Toxicology Annual Meeting, New Orleans, LA, March 06 - 10, 2005.

POWER, F. W., J. B. KNAAK, M. S. OKINO, R. TORNERO-VELEZ, J. N. BLANCATO, AND C. C. DARY. USE OF EXPOSURE-RELATED DOSE ESTIMATING MODEL (ERDEM) FOR ASSESSMENT OF AGGREGATE EXPOSURE OF INFANT AND CHILDREN TO N-METHYL CARBAMATE INSECTICIDES. Presented at Society of Toxicology Annual Meeting, New Orleans, LA, March 06 - 10, 2005.

TORNERO-VELEZ, R., N. S. TULVE, M. S. OKINO, AND C. C. DARY. USE OF PBPK MODELING TO ASSESS CYPERMETHRIN EXPOSURE IN YOUNG AFTER A RESIDENTIAL APPLICATION. Presented at International Society of Exposure Analysis Conference, Tucson, AZ, October 30 - November 03, 2005.

OKINO, M. S., G. CHAPA, K. W. THOMAS, G. L. ROBERTSON, C. B. THOMPSON, A. TSANG, FRED W. POWER, J. B. KNAAK, AND C. C. DARY. USE OF PHARMACOKINETIC MODELS TO ASSESS OCCUPATIONAL AND RESIDENTIAL PESTICIDE EXPOSURE. Presented at International Society for Exposure Analysis Conference, Tucson, AZ, October 30 - November 03, 2005.

Ruiz, A., A. Tsang, J. Licitra, F W. Power, J N. Blancato, AND C C. Dary. A COMPREHENSIVE APPROACH FOR PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODELS USING THE EXPOSURE RELATED DOSE ESTIMATING MODEL (ERDEM) SYSTEM. Presented at 43rd Annual Meeting of the Society of Toxicology, Baltimore, MD, March 21-25, 2004.

TORNERO-VELEZ, R, C C. Dary, M Dellarco, AND J Blancato. A PBPK MODEL OF PYRETHROID PESTICIDES FOR APPLICATION IN RISK ASSESSMENT. Presented at Exposure Assessment in a Changing Environment, Utrecht, The Netherlands, June 16-18, 2004.

Dary, C C., M Dellarco, J N. Blancato, AND R. TORNERO-VELEZ. A PRELIMINARY PBPK MODEL OF PYRETHROID PESTICIDES FOR APPLICATION IN ENVIRONMENTAL RISK ASSESSMENT. Presented at X2004 - Exposure Assessment in a Changing Environment, Utrecht, The Netherlands, June 16-18, 2004.

TORNERO-VELEZ, R, W. Longest, S. Harper, C C. Dary, AND J Blancato. ADVANCED COMPUTATIONAL METHODS IN DOSE MODELING: APPLICATION OF COMPUTATIONAL BIOPHYSICAL TRANSPORT, COMPUTATIONAL CHEMISTRY, AND COMPUTATIONAL BIOLOGY. Presented at EPA Science Forum 2004, Washington, DC, June 1-3, 2004.

Blancato, J, C C. Dary, M S. Okino, F W. Power, A. Ruiz, AND R. TORNERO-VELEZ. APPLICATION OF ERDEM IN RISK ASSESSMENT: HEALTH EFFECTS DIVISION'S RISK ASSESSOR TRAINING AND CERTIFICATION PROGRAM. Presented at Health Effects Division's Risk Assessor Training and Certification Program, Washington, DC, August 11-12, 2004.

Evans, M V., F W. Power, C C. Dary, R. TORNERO-VELEZ, AND J. Blancato. APPLICATION OF THE EXPOSURE DOSE ESTIMATING MODEL (ERDEM) TO ASSESSMENT OF DERMAL EXPOSURE IN THE RAT TO MALATHION. Presented at Society of Toxicology, Baltimore, MD, March 21-25, 2004.

Ruiz, A., A. Tsang, F W. Power, J. Licitra, J N. Blancato, C C. Dary, AND M V. Evans. COMPREHENSIVE PBPK MODELING APPROACH USING THE EXPOSURE RELATED DOSE ESTIMATING MODEL (ERDEM). Presented at Society of Toxicology, Baltimore, MD, March 21-25, 2004.

Lowit, A., C C. Dary, F W. Power, J Blancato, R. W. Setzer, R. Conolly, AND M. Seaton. PHYSIOLOGICALLY-BASED PHARMACOKINETIC/PHARMACODYNAMIC MODELING AND CUMULATIVE RISK ASSESSMENT: CASE STUDY FOR THE N-METHYL CARBAMATE PESTICIDES. Presented at EPA Science Forum 2004, Washington, DC, June 1-3, 2004.

Lowit, A., C C. Dary, F W. Power, J Blancato, R. W. Setzer, R. Conolly, AND M. Seaton. PHYSIOLOGICALLY-BASED PHARMACOKINETICS/PHARMACODYNAMIC MODELING AND CUMULATIVE RISK ASSESSMENT: CASE STUDY FOR THE N-METHYL CARBMATE PESTICIDES. Presented at EPA Science Forum 2004, Washington, DC, June 1-3, 2004.

TORNERO-VELEZ, R, H P. Nichols, M V. Evans, M J. DeVito, C C. Dary, M Dellarco, AND J Blancato. TOWARDS A GENERIC PBPK MODEL OF PYRETHROID PESTICIDES: MODELING DELTAMETHRIN AND PERMETHRIN IN THE RAT. Presented at Society of Toxicology, Baltimore, MD, March 21-25, 2004.

TORNERO-VELEZ, R, C C. Dary, J. B. Knaak, F W. Power, AND M Dellarco. A COMPARATIVE INVESTIGATION OF THE INFLUENCE OF DERMAL APPENDAGES (HAIR FOLLICLES) ON THE PERCUTANEOUS ABSORPTION OF ORGANOPHOSPHORUS (OP) INSECTICIDES USING QSAR AND PBPK/PD MODELS FOR HUMAN RISK ASSESSMENT. Presented at International Society of Exposure Analysis, Stresa, Italy, September 21-25, 2003.

Knaak, J. B., R TORNERO-VELEZ, F W. Power, J N. Blancato, AND C C. Dary. BETTER EXPOSURE-DOSE MODELS FOR PESTICIDES. Presented at Science Forum 2003, Washington, DC, May 5-7, 2003.

Knaak, J. B., F W. Power, J N. Blancato, AND C C. Dary. THE IMPORTANCE OF OBTAINING INFORMATION ON THE SPECIFIC CONTENT OF TISSUE ENZYMES METABOLIZING ORGANOPHOSPHORUS PESTICIDES, PRIOR TO DETERMINE VMAX, KM VALUES FOR USE IN PBPK MODELS. Presented at Science Forum 2003, Washington, DC, May 5-7, 2003.

Knaak, J. B., F W. Power, J N. Blancato, AND C C. Dary. THE IMPORTANCE OF OBTAINING INFORMATION ON THE SPECIFIC CONTENT OF TISSUE ENZYMES METABOLIZING ORGANOPHOSPHORUS PESTICIDES, PRIOR TO DETERMINING VMAX, KM VALUES FOR USE IN PBPK MODELS. Presented at American Chemical Society, New Orleans, LA, March 23-27, 2003.

Dary, C C., E J. Furtaw Jr., F W. Power, AND J N. Blancato. PHYSIOLOGICALLY-BASED PHARMACOKINETIC AND PHARMACODYNAMIC (PBPK/PD) MODEL FOR PREDICTING THE DERMAL DOSE AND DISPOSITION OF ORGANOPHOSPHORUS INSECTICIDES. Presented at Society for Risk Analysis Meeting, New Orleans, LA, December 8-11, 2002.