Science Inventory

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Langley, G., I. Adcock, F. Busquet, K. Crofton, E. Csernok, C. Giese, T. Heinonen, K. Herrmann, M. Hofmann-Apitius, B. Landesmann, L. Marshall 11, E. McIvor, A. Muotri, F. Noor, K. Schutte, T. Seidle, A. van de Stolpe, H. Van Esch, C. Willett, AND G. Woszczek. Towards a 21st century roadmap for biomedical research and drug discovery: Consensus report and recommendations. DRUG DISCOVERY TODAY. Elsevier Science Ltd, New York, NY, , 1-13, (2016).

Shah, I., Woodrow Setzer, J. Jack, K. Houck, R. Judson, T. Knudsen, J. Liu, M. Martin, D. Reif, Ann M. Richard, Russell S. Thomas, K. Crofton, David J. Dix, AND Robert J. Kavlock. Using ToxCast data to reconstruct dynamic cell state trajectories and estimate toxicological points of departure. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 124(7):910-919, (2016).

Wilson, V., G. LeBlanc, S. Kullman, K. Crofton, P. Schmieder, AND M. Jacobs. Where do we go from here: Challenges and the future of endocrine disrupting compound screening and testing. PeerJ. PeerJ Inc., Corte Madera, CA, 4:e2605v1, (2016).

Crofton, K. Adverse Outcome Pathways: Challenges in Use and Development . Presented at Global Chem Meeting, Baltimore, MD, March 03, 2015. https://doi.org/10.23645/epacomptox.5080000

Watt, E., D. F. Kapraun, T. B. Knudsen, K. Crofton, AND R. Judson. Computational Modeling of Thyroid Hormone Regulated Neurodevelopment for Chemical Prioritization (SOT). Presented at SOT Annual Meeting, San Diego, CA, March 22 - 26, 2015.

Crofton, K. Developing Data and Computational Models to Enhance Risk Decisions: An Update on ToxCast and ExpoCast (Dalian University, China). Presented at Dahlian University presentation, Dalian, CHINA, April 22, 2015. https://doi.org/10.23645/epacomptox.5079982

Crofton, K. Developing Data and Computational Models to Enhance Risk Decisions: An Update on ToxCast and ExpoCast (ISCRPM). Presented at 2015 International Symposium on Chemicals Risk Prediction and Management (ISCRPM-2015), Xiamen, CHINA, April 23 - 24, 2015. https://doi.org/10.23645/epacomptox.5080009

Paul Friedman, K., Eric Watt, J. Hedge, K. Crofton, M. Hornung, AND Steve Simmons. Development of a tiered screening strategy for a molecular-initiating event: thyroperoxidase inhibition (SOT). Presented at SOT Annual Meeting, San Diego, CA, March 22 - 26, 2015. https://doi.org/10.23645/epacomptox.5178835

Aoyama, H., N. Takahashi, Y. Shutoh, A. Motomura, AND K. Crofton. Developmental Neurotoxicology: History and Outline of Developmental Neurotoxicity Study Guidelines. Food Safety. Food Safety Commission, Cabinet Office, Government of Japan, TOKYO, Japan, 3(2):48-61, (2015).

Knudsen, T. B., A. M. Richard, P. G. Kothiya, R. S. Judson, K. A. Houck, K. C. Crofton, R. S. Thomas, S. Little, E. S. Hunter, N. C. Baker, C. K. M. Leung, J. Palmer, A. Smith, M. Colwell, P. West, R. Burrier, AND L. Egnash. Evaluation of 1066 ToxCast Chemicals in a human stem cell assay for developmental toxicity (SOT). Presented at Society of Toxicology, San Diego, CA, March 21 - 26, 2015. https://doi.org/10.23645/epacomptox.5178703

Segal, D., S. Makris, A. Kraft, A. Bale, M. Gilbert, D. Bergfelt, K. Raffaele, R. Blain, K. Fedak, M. Selegrade, AND K. Crofton. Evaluation of the ToxRTool's ability to rate the reliability of toxicological data for human health hazard assessments. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 72(1):94-101, (2015).

Mundy, W., S. Padilla, J. Breier, K. Crofton, M. Gilbert, D. Herr, K. Jensen, N. Radio, K. Raffaele, K. Schumacher, Tim Shafer, AND J. Cowden. Expanding the test set: Chemicals with potential to disrupt mammalian brain development. NEUROTOXICOLOGY AND TERATOLOGY. Elsevier Science Ltd, New York, NY, 52:25-35, (2015).

Judson, Richard S., F. Magpantay, V. Chickarmane, C. Haskell, N. Tania, J. Taylor, M. Xia, R. Huang, D. Rotroff, D. Filer, K. Houck, M. Martin, N. Sipes, A. Richard, K. Mansouri, Woodrow Setzer, T. Knudsen, K. Crofton, AND R. Thomas. Integrated Model of Chemical Perturbations of a Biological PathwayUsing 18 In Vitro High Throughput Screening Assays for the Estrogen Receptor. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, :1-42, (2015).

Bal-Price, A., K. Crofton, M. Leist, S. Allen, M. Arand, T. Buetler, N. Delrue, R. FitzGerald, T. Hartung, T. Heinonen, H. Hogberg, S. Hougaard Bennekou, W. Lichtensteiger, D. Oggier, M. Paparella, M. Axelstad, A. Piersma, E. Rached, B. Schilter, G. Schmuck, L. Stoppini, E. Tongiorgi, M. Tiramani, F. Monnet-Tschudi, M. Wilks, T. Ylikomi, AND E. Fritsche. International STakeholder NETwork (ISTNET): Creating a Developmental Neurotoxicity Testing (DNT) Roadmap for Regulatory Purposes. Archives of Toxicology. Springer, New York, NY, 89(2):269-287, (2015).

Crofton, K. New Strategies for Regulatory Developmental Neurotoxicity Testing: Translating HTS Bioassay Results to Risk Estimates (DENAMIC Workshop). DENAMIC Workshop, Amsterdam, NETHERLANDS, December 07 - 08, 2015. https://doi.org/10.23645/epacomptox.5071249

Baghdikian, C., T. Bahadori, R. Thomas, K. Crofton, AND M. Linnenbrink. Stakeholder engagement and feedback efforts to increase use of the iCSS ToxCast Dashboard (SETAC). Presented at Society of Environmental Toxicology and Chemistry, Salt Lake City, UT, November 01 - 05, 2015.

Bouhifd, M., M. Andersen, C. Baghdikian, K. Boekelheide, K. Crofton, A. Fornace Jr., A. Kleensang, H. Li, C. Livi, A. Maertens, P. McMullen, M. Rosenberg, R. Thomas, M. Vantangoli, J. Yager, L. Zhao, AND T. Hartung. The Human Toxome Project. ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, 32:112-124, (2015).

Baghdikian, C., R. Thomas, T. Bahadori, K. Crofton, AND M. Linnenbrink. Tutorial Video Series: Using Stakeholder Outreach to Increase Usage of ToxCast Data (SETAC EU). Presented at Society of Environmental Toxicology and Chemistry, Barcelona, SPAIN, May 03 - 07, 2015.

Baghdikian, C., T. Bahadori, R. Thomas, K. Crofton, AND M. Linnenbrink. Tutorial Video Series: Using Stakeholder Outreach to Increase Usage of ToxCast Data (SOT). Presented at SOT Annual Meeting, San Diego, CA, March 22 - 26, 2015. https://doi.org/10.23645/epacomptox.5178913

Lynn, S., M. Hornung, M. Gilbert, S. Degitz, AND K. Crofton. A Risk-based Prioritization Strategy for Thyroid Disruption Under EDSP21. Presented at Teratology Society Meeting, Bellevue, WA, June 28 - July 02, 2014.

Tollefsena, K., S. Scholz, M. Cronin, S. Edwards, J. de Knecht, K. Crofton, N. Garcia-Reyero, T. Hartung, A. Worth, AND C. Patlewicz. Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA workshop report). REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 70(3):629-640, (2014).

Paul, K., J. Hedge, D. Rotroff, M. Hornung, K. Crofton, AND Steve Simmons. Development of a thyroperoxidase inhibition assay for high-throughput screening. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 27(3):387-99, (2014).

Starr, J., S. Graham, D. Ross, R. Tornero-Velez, E. Scollon, M. DeVito, K. Crofton, M. Wolansky, AND M. Hughes. Environmentally Relevant Mixing Ratios in Cumulative Assessments: A Study of the Kinetics of Pyrethroids and Their Ester Cleavage Metabolites in Blood and Brain; and the Effect of a Pyrethroid Mixture on the Motor Activity of Rats. TOXICOLOGY. Elsevier Science Ltd, New York, NY, 320:1-82, (2014).

Judson, R., K. Houck, M. Martin, T. Knudsen, R. Thomas, N. Sipes, I. Shah, J. Wambaugh, AND K. Crofton. In Vitro and Modeling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Program. BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. Blackwell Publishing, Malden, MA, 115(1):69-76, (2014).

Murk, A., E. Rijntjes, B. Blaauboer, R. Clewell, K. Crofton, M. Dingemans, J. Furlow, R. Kavlock, J. Köhrle, R. Opitz, T. Traas, T. Visser, M. Xia, AND A. Gutleb. Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 27(4):1320-1346, (2013).