Science Inventory

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Leonard, J., D. Chang, H. El-Masri, S. Edwards, C. Stevens, K. Mansouri, P. Egeghy, AND C. Tan. A tiered approach for integrating exposure and dosimetry with in vitro dose-response data in the modern risk assessment paradigm. 254th ACS National Meeting & Exposition, Washington, DC, August 20 - 24, 2017.

Hassan, I., H. El-Masri, Pat Kosian, J. Ford, S. Degitz, AND M. Gilbert. Neurodevelopment and Thyroid Hormone Synthesis Inhibition in the Rat: Quantitative Understanding Within the Adverse Outcome Pathway Framework. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 160(1):57-73, (2017).

El-Masri, H., M. Jasper, AND M. Gilbert. Physiologically-Based Pharmacokinetic (PBPK) Model for the Thyroid Hormones in the Pregnant Rat and Fetus. Society of Toxicology, Baltimore, MD, March 12 - 16, 2017.

Hassan, I., H. El-Masri, Pat Kosian, J. Ford, R. Ford, M. Jasper, S. Degitz, AND M. Gilbert. Quantitative Adverse Outcome Pathway for Neurodevelopmental Effects of Thyroid Peroxidase-Induced Thyroid Hormone Synthesis Inhibition. Society of Toxicology, Baltimore, MD, March 12 - 16, 2017.

Phillips, M., J. Leonard, Chris Grulke, D. Chang, S. Edwards, R. Brooks, M. Goldsmith, H. El-Masri, AND C. Tan. A Workflow to Investigate Exposure and Pharmacokinetic Influences on High-Throughput in Vitro Chemical Screening Based on Adverse Outcome Pathways. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 124(1):53-60, (2016).

Jasper, M., S. Martin, W. Oshiro, J. Ford, P. Bushnell, AND H. El-Masri. Application of Biologically-Based Lumping To Investigate the Toxicological Interactions of a Complex Gasoline Mixture. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 50(6):3231-3238, (2016).

Leonard, J., C. Tan, M. Gilbert, K. Isaacs, AND H. El-Masri. Estimating Margin of Exposure to Thyroid Peroxidase Inhibitors Using High-throughput In Vitro Data, High-throughput Exposure Modeling, and Physiologically-Based Pharmacokinetic/Pharmacodynamic Modeling. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 151(1):57-70, (2016).

Suarez, S. AND H. El-Masri. Identification of Absorption, Distribution, Metabolism, and Excretion (ADME) Genes Relevant to Steatosis Using a Differential Gene Expression Approach. SOT, New Orleans, LA, March 13 - 17, 2016.

El-Masri, H., N. Kleinstreuer, R. Hines, Lindad Adams, T. Tal, K. Isaacs, B. Wetmore, AND C. Tan. Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 152(1):230-243, (2016).

Tan, C., H. El-Masri, S. Edwards, J. Leonard, S. Suarez, AND K. Fay. Integration of chemical-specific exposure and pharmacokinetic information with the chemical-agnostic AOP framework to support high throughput risk assessment. Chemical Safety for Sustainability Subcommittee Meeting, Durham, NC, November 16 - 17, 2016.

El-Masri, H. Life-Stage Physiologically-Based Pharmacokinetic (PBPK) Model Applications to Screen Environmental Hazards. SOT, New Orleans, LA, March 13 - 17, 2016.

Tan, C., J. Leonard, D. Chang, H. El-Masri, S. Edwards, AND R. Goldsmith. A three-tiered approach for linking pharmacokinetic considerations to the adverse outcome pathway framework for chemical-specific risk assessment. SETAC, Salt Lake City, UT, Salt Lake City, UT, November 01 - 04, 2015.

Tan, C., M. Phillips, H. El-Masri, AND S. Edwards. An “ADME Module” in the Adverse Outcome Pathway Knowledgebase. Society of Toxicology 2015 Annual Meeting, San Diego, CA, March 23 - 27, 2015.

Suarez, S., J. Lawson, AND H. El-Masri. Identification of Absorption, Distribution, Metabolism, and Excretion (ADME) Genes Relevant to Steatosis Using a Systems Biology Approach. Integrated Approaches to Testing and Assessment: Promises and Challenges of a More Flexible Approach to Toxicology Testing 4th Annual ASCCT Meeting, Durham, NC, October 01 - 02, 2015.

El-Masri, H., E. McLanahan, AND S. Martin. Principles of Toxicokinetics and Predictive Toxicokinetics Modeling. Edition 1, Chapter 5, Mohamed Abou-Donia (ed.), Mammalian Toxicology. John Wiley & Sons Incorporated, New York, NY, 1:85-98, (2015).

Martin, S., E. McLanahan, P. Bushnell, S. Hunter, AND H. El-Masri. Species Extrapolation of Life-Stage Physiologically-Based Pharmacokinetic (PBPK) Models to Investigate the Developmental Toxicology of Ethanol Using In vitro to In vivo (IVIVE) Methods. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 143(2):512-35, (2015).

Wambaugh, J., C. Strope, C. Nicolas, R. Pearce, R. Judson, Rocky Goldsmith, H. El-Masri, B. Wetmore, J. Sluka, A. Tropsha, S. Bosgra, I. Shah, R. Thomas, AND Woodrow Setzer. High Throughput Pharmacokinetics for Environmental Chemicals (FutureToxII). Presented at SOT CCT FutureTox II, Chapel Hill, NC, January 16 - 17, 2014.

Lehmann, G., M. Verner, B. Luukinen, C. Henning, S. Assimon, J. LaKind, E. McLanahan, L. Phillips, M. Davis, Christina Powers, E. Hines, S. Haddad, M. Longnecker, M. Poulsen, D. Farrer, S. Marchitti, Y. TAN, Jeff Swartout, S. SAGIV, C. Welsh, J. Campbell, W. Foster, R. Yang, S. Fenton, R. Tornero-Velez, B. Francis, J. Barnett, H. El-Masri, AND Jane Ellen Simmons. Improving the risk assessment of lipophilic persistent environmental chemicals in breast milk. CRITICAL REVIEWS IN TOXICOLOGY. CRC Press LLC, Boca Raton, FL, 44(7):600-617, (2014).

Martin, S., W. Oshiro, P. Evansky, J. Ford, L. Degn, H. El-Masri, E. McLanahan, D. MacMillan, W. Boyes, AND P. Bushnell. PBPK Models for Gasoline-Ethanol Biofuels in Adult and Pregnant Rats. Presented at Society of Toxicology, Phoenix, AZ, March 23 - 27, 2014.

Martin, S., W. Oshiro, P. Evansky, J. Ford, L. Degn, H. El-Masri, E. McLanahan, D. MacMillan, W. Boyes, AND P. Bushnell. PBPK Models for Gasoline-Ethanol Biofuels in Adult and Pregnant Rats###. Presented at Society of Toxicology, Phoenix, AZ, March 23 - 27, 2014.

Martin, S., W. Oshiro, P. Evansky, J. Ford, L. Degn, H. El-Masri, E. McLanahan, D. MacMillan, W. Boyes, AND P. Bushnell. PBPK Models for Gasoline-Ethanol Biofuels in Adult and Pregnant Rats####. Presented at Society of Toxicology, Phoenix, AZ, March 23 - 27, 2014.

Martin, S., W. Oshiro, P. Evansky, J. Ford, L. Degn, H. El-Masri, E. McLanahan, D. MacMillan, W. Boyes, AND P. Bushnell. PBPK Models for Gasoline-Ethanol Biofuels in Adult and Pregnant Rats**. Presented at Society of Toxicology, Phoenix, AZ, March 23 - 27, 2014.

Martin, S., W. Oshiro, P. Evansky, J. Ford, L. Degn, H. El-Masri, E. McLanahan, D. MacMillan, W. Boyes, AND P. Bushnell. PBPK Models for Gasoline-Ethanol Biofuels in Adult and Pregnant Rats@@@@. Presented at Society of Toxicology, Phoenix, AZ, March 23 - 27, 2014.

Adams, Lindad, H. El-Masri, J. Wambaugh, T. Tal, N. Baker, Chris Mazur, S. Marchitti, AND J. Kenneke. Physiologically-based Pharmacokinetic(PBPK) Models Application to Screen Environmental Hazards Related to Adverse Outcome Pathways(AOPs). Presented at Society of Toxicology, Phoenix, AZ, March 23 - 27, 2014.

Martin, S., W. Oshiro, P. Evansky, L. Degn, A. Ledbetter, J. Ford, Todd Krantz, W. Lefew, T. Beasley, H. El-Masri, E. McLanahan, W. Boyes, AND P. Bushnell. Use of novel inhalation kinetic studies to refine physiologically-based-pharmacokinetic models for ethanol in non-pregnant and pregnant rats. INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, 26(10):598-619, (2014).