Science Inventory

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Strickland, J., K. Wallace, M. Martin, K. Houck, J. Ross, AND Tim Shafer. Concentration-response assessment of ToxCast Phase II compounds on spontaneous neural network activity in vitro. 2017 Society of Toxicology Annual Meeting, Baltimore, MD, March 12 - 16, 2017.

Kleinstreuer, N., P. Ceger, Eric Watt, M. Martin, K. Houck, P. Browne, R. Thomas, W. Casey, D. Dix, D. Allen, S. Sakamuru, M. Xia, R. Huang, AND R. Judson. Development and Validation of a Computational Model for Androgen Receptor Activity. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 30(4):946-964, (2017).

Flood, S., K. Houck, AND Chris Grulke. Development of a Context-Rich Database of ToxCast Assay Annotations (SOT). Presented at SOT Annual Meeting, Baltimore, MD, March 12 - 16, 2017. https://doi.org/10.23645/epacomptox.5178610

Houck, K. EPA’s ToxCast Program: Update on CBCRP-Relevant Work (CBCRP Annual Meeting). Presented at CBCRP Annual Meeting, Berkeley, California, April 06, 2017. https://doi.org/10.23645/epacomptox.5056819

Houck, K., C. LaLone, R. Judson, M. Martin, Dan Villeneuve, G. Ankley, A. Medvedev, AND S. Markarorav. Evaluation of an In Vitro Multi-Receptor and Multi-Species Assay for Potential Endocrine Disruptor Targets (SOT). Presented at SOT National Meeting, Baltimore, MD, March 12 - 16, 2017.

Bone, A., M. Xia, S. Sakamuru, R. Huang, R. Houtman, R. van Beuningen, Eric Watt, N. Kleinstreuer, R. Judson, AND K. Houck. Identification of Androgen Receptor Antagonists using Tox21 qHTS Data and the MARCoNI Assay. Society of Toxicology Annual Meeting, Baltimore,MD, March 12 - 16, 2017. https://doi.org/10.23645/epacomptox.6791795.v2

Lynch, C., S. Sakamuru, R. Huang, D. Stavea, L. Varticovski, G. Hager, Richard S. Judson, Keith A. Houck, N. Kleinstreuer, W. Casey, R. Paules, A. Simeonov, AND M. Xia. Identifying Environmental Chemicals as Agonists of the Androgen Receptor by Applying a Quantitative High-throughput Screening Platform. TOXICOLOGY. Elsevier Science Ltd, New York, NY, 385:48-58, (2017).

Judson, R., K. Houck, T. Knudsen, Eric Watt, S. Mosher, T. Tal, AND S. Padilla. Modeling Zebrafish Developmental Toxicity using a Concurrent In vitro Assay Battery (SOT). Presented at SOT 2017, Baltimore, MD, March 12 - 16, 2017. https://doi.org/10.23645/epacomptox.5178586

Judson, R., K. Houck, Eric Watt, AND R. Thomas. On Selecting a Minimal Set of In Vitro Assays to Reliably Determine Estrogen Agonist Activity. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 91:39-49, (2017).

Harrill, J., M. Martin, K. Houck, R. Judson, K. Crofton, AND R. Thomas. Optimization Of A High-Throughput Transcriptomic (HTTr) Bioactivity Screen In MCF7 Cells Using Targeted RNA-Seq (SOT). Presented at SOT annual meeting, Baltimore, MD, March 12 - 16, 2017. https://doi.org/10.23645/epacomptox.5176789

Paul-Friedman, K., J. Zhao, R. Huang, M. Xia, K. Crofton, AND K. Houck. Screening the Tox21 10K library for thyroid stimulating hormone receptor agonist and antagonist activity (SOT annual meeting). Presented at SOT Annual Meeting, Baltimore, Maryland, March 12 - 16, 2017. https://doi.org/10.23645/epacomptox.5176897

Strickland, J., M. Martin, K. Houck, J. Ross, AND Tim Shafer. Screening the ToxCast Phase II library for acute neurotoxicity using cortical neurons grown on multi-well microelectrode array (mwMEA) plates. 2017 International Neurotoxicology Association Meeting, Florianopolis, BRAZIL, May 20 - 24, 2017.

Strickland, J., M. Martin, A. Richard, K. Houck, AND Tim Shafer. Screening the ToxCast phase II libraries for alterations in network function using cortical neurons grown on multi-well microelectrode array (mwMEA) plates. Archives of Toxicology. Springer, New York, NY, 92(1):487-500, (2018). https://doi.org/10.1007/s00204-017-2035-5

Flood, S. AND K. Houck. ToxCast Assay Descriptions (originally presented at CSS meeting, and will be released to external stakeholders). Presented at CSS monthly meeting, RTP, NC, April 10, 2017.

Houck, K. Toxicity Testing in the 21st Century EPA’s CompTox Approach (TAMU CVM lecture)EPA’s CompTox Approach (TAMU CVM). Presented at TA&MU CVM lecture, College Station, Texas, April 28, 2017.

Thomas, R., D. Zink, L. Loo, K. Houck, H. Yu, I. Shah, F. Ginhoux, AND T. Knudsen. US EPA - A*Star Partnership - Accelerating the Acceptance of Next-Generation Sciences and Their Application to Regulatory Risk Assessment (A*Star Symposium, Singapore). Presented at A*STAR Symposium, Singapore, Singapore, SINGAPORE, February 04 - 08, 2017.

Judson, R., K. Houck, M. Martin, A. Richard, T. Knudsen, I. Shah, S. Little, J. Wambaugh, Woodrow Setzer, P. Kothiya, J. Phuong, D. Filer, D. Smith, D. Reif, D. Rotroff, N. Kleinstreuer, N. Sipes, M. Xia, R. Huang, K. Crofton, AND R. Thomas. Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 152(2):323-339, (2016).

Blackwell, B., G. Ankley, P. Bradley, S. Li, K. Houck, AND Dan Villeneuve. Application of the Attagene FACTORIAL™ assay to characterization of surface waters from a nationwide assessment of streams. SETAC North America, Orlando, FL, November 06 - 10, 2016.

Blackwell, B., A. Schroeder, K. Houck, G. Ankley, AND Dan Villeneuve. Application of the high throughput Attagene Factorial TM platform to environmental monitoring: Characterizing complex, environmental mixtures. Society of Toxicology, New Orleans, LA, March 13 - 17, 2016.

Strickland, J., M. Martin, A. Richard, AND K. Houck. Characterization of ToxCast Phase II compounds disruption of spontaneous network activity in cortical networks grown on multi-well microelectrode array (mwMEA) plates. Society of Toxicology Annual Meeting, New Orleans, LA, March 13 - 17, 2016.

Deal, S., J. Wambaugh, R. Judson, S. Moser, N. Radio, K. Houck, AND S. Padilla. Development of a Quantitative Morphological Assessment of Toxicant-Treated Zebrafish Larvae Using Brightfield Imaging and High Content Analysis. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 36:1214-1222, (2016). https://doi.org/10.1002/jat.3290

Houck, K. EPA’s ToxCast Program: Covering the Mechanistic Space (CBCRP Meeting). Presented at CBCRP Meeting, Berkeley, CA, March 01, 2016. https://doi.org/10.23645/epacomptox.5071273

Schroeder, A., G. Ankley, K. Houck, AND Dan Villeneuve. Environmental surveillance and monitoring. The next frontiers for high-throughput toxicology. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 35(3):513-525, (2016).

Bone, A., G. Patlewicz, AND K. Houck. Evaluation and comparison of bisphenol A analog activity using ToxCast data (SOT). Presented at Society of Toxicology Annual Meeting, New Orleans, LA, March 13 - 17, 2016. https://doi.org/10.23645/epacomptox.5176606

Karmaus, A., D. Filer, M. Martin, AND K. Houck. Evaluation of food-relevant chemicals in the ToxCast high-throughput screening program. FOOD AND CHEMICAL TOXICOLOGY. Elsevier Science Ltd, New York, NY, 92:188-196, (2016).