Science Inventory

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Theunissen, P., S. Beken, B. Beyer, W. Breslin, G. Cappon, C. Chen, G. Chmielewski, L. De Schaepdrijver, B. Enright, J. Foreman, W. Harrouk, K. Hew, A. Hoberman, J. Hui, TB Knudsen, S. Laffan, S Makris, AND M Martin. Comparing rat and rabbit embryo-fetal developmental toxicity studies for 379 pharmaceuticals: On systemic dose and developmental effects (Critical Reviews in Toxicology) . CRITICAL REVIEWS IN TOXICOLOGY. CRC Press LLC, Boca Raton, FL, , 1-13, (2016).

Theunissen, P., S. Beken, B. Beyer, W. Breslin, G. Cappon, C. Chen, G. Chmielewski, L. De Schaepdrijver, B. Enright, J. Foreman, W. Harrouk, K. Hew, A. Hoberman, J. Hui, TB Knudsen, S. Laffan, S Makris, M Martin, M. McNerney, C. Siezen, D. Stanislaus, J. Stewart, K. Thompson, B. Tornesi, G. Weinbauer, S. Wood, J. Van der Laan, AND A. Piersma. Comparison of rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects (Critical Reviews in Toxicology) . CRITICAL REVIEWS IN TOXICOLOGY. CRC Press LLC, Boca Raton, FL, , 1-11, (2016).

Filer, Dayne L., P. Kothiya, R. Woodrow Setzer, Richard S. Judson, AND Matthew T. Martin. tcpl: The ToxCast Pipeline for High-Throughput Screening Data. BIOINFORMATICS. Oxford University Press, Cary, NC, , 1-3, (2016).

Martin, M. T., A Karmaus, M. Black, J. Naciff, G. Daston, E. Carney, M. Andersen, R. S. Thomas, AND B. Wetmore. Comparison of L1000 and Affymetrix Microarray for In Vitro Concentration-Response Gene Expression Profiling (SOT). Presented at SOT annual meeting, San Diego, CA, March 22 - 26, 2015. https://doi.org/10.23645/epacomptox.5178763

Liu, J., K. Mansouri, Richard S. Judson, Matthew T. Martin, H. Hong, M. Chen, X. Xu, Russell S. Thomas, AND I. Shah. Predicting hepatotoxicity using ToxCast in vitro bioactivity and chemical structure. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 28(4):738-751, (2015).

Truong, L., G. Ouedraogo, S. Loisel-Joubert, H. Nocairi, AND M. T. Martin. Quantitative Predictive Models for Systemic Toxicity (SOT). Presented at SOT annual meeting, San Diego, CA, March 22 - 26, 2015. https://doi.org/10.23645/epacomptox.5178820

WAMBAUGH, J. F., WOODROW SETZER, A. M. Pitruzzello, J. Liu, D. M. Reif, N. C. Kleinstreuer, N. Y. WANG, N. SIPES, M. T. MARTIN, K. DAS, J. C. DeWitt, M. STRYNAR, R. JUDSON, K. A. HOUCK, AND C. LAU. Dosimetric Anchoring of In Vivo and In Vitro Studies for Perfluorooctanoate and Perfluorooctanesulfonate. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 136(2):308-327, (2013).

JUDSON, R., R. J. KAVLOCK, M. T. MARTIN, D. REIF, K. A. HOUCK, T. B. KNUDSEN, A. M. RICHARD, R. R. TICE, M. WHELAN, M. XIA, R. HUANG, C. P. AUSTIN, G. P. DASTON, T. HARTUNG, J. R. FOWLE III, W. WOOGE, W. TONG, AND D. J. DIX. Perspectives on Validation of High-Throughput Assays Supporting 21st Century Toxicity Testing. Sonja von Aulock (ed.), ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, 30(1/13):51-66, (2013).

KNUDSEN, T. B., M. T. MARTIN, K. J. CHANDLER, N. KLEINSTREUER, R. JUDSON, AND N. SIPES. Predictive Models and Computational Toxicology. Chapter 26, Paul C.Barrow (ed.), Teratogenicity Testing; Methods and Protocols. Humana Press Incorporated, Totowa, NJ, 947:343-374, (2013).

ROTROFF, D., D. J. DIX, K. A. HOUCK, R. J. KAVLOCK, T. B. KNUDSEN, M. T. MARTIN, D. REIF, A. M. RICHARD, N. SIPES, Y. A. ABASSI, C. JIN, M. STAMPFL, AND R. JUDSON. Real-Time Growth Kinetics Measuring Hormone Mimicry for ToxCast Chemicals in T‑47D Human Ductal Carcinoma Cells . CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 26(7):1097-1107, (2013).

HOUCK, K. A., A. M. RICHARD, R. S. JUDSON, M. T. MARTIN, D. REIF, AND I. A. SHAH. ToxCast: PREDICTING TOXICITY POTENTIAL THROUGH HIGH-THROUGHPUT BIOACTIVITY PROFILING. 1st Edition, , Chapter 1, Pablo Steinberg (ed.), High-Throughput Screening Methods in Toxicity Testing. John Wiley & Sons, Inc, Hoboken, NJ, , 3-31, (2013).

OUEDRAOGO, G., A. DETROYER, L. BOUROUF, H. NOCAIRI, S. LOISEL, C. CHETTAOUI, R. NOTE, S. RINGEISSEN, J. MEUNIER, P. BERTHE, D. REIF, M. T. MARTIN, A. M. RICHARD, R. JUDSON, D. J. DIX, AND R. J. KAVLOCK. A MAPPING BASED ON PHYSICO-CHEMICAL FEATURES: LESSONS LEARNT. Presented at The Society of Toxicology (SOT) 51st Annual Meeting and ToxExpo 2012, Moscone Convention Center, San Francisco, CA, March 11 - 15, 2012.

SIPES, N., D. REIF, KEITH A. HOUCK, M. T. MARTIN, P. KOTHIYA, A. M. RICHARD, R. JUDSON, T. B. KNUDSEN, D. J. DIX, AND R. J. KAVLOCK. Activity profiles of 676 ToxCast Phase II compounds in 231 biochemical high-throughput screening assays. Presented at The Society of Toxicology (SOT) 51st Annual Meeting and ToxExpo 2012, Moscone Convention Center, San Francisco, CA, March 11 - 25, 2012.

JUDSON, R. S., M. T. MARTIN, P. P. EGEGHY, S. GANGWAL, D. M. REIF, P. KOTHIYA, M. A. WOLF, T. CATHEY, T. R. TRANSUE, D. SMITH, J. VAIL, A. FRAME, S. MOSHER, E. A. COHEN-HUBAL, AND A. M. RICHARD. Aggregating Data for Computational Toxicology Applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System. International Journal of Molecular Sciences. MDPI, Basel, Switzerland, 13(2):1805-1831, (2012).

KLEINSTREUER, N., K. A. HOUCK, R. JUDSON, D. REIF, P. KOTHIYA, M. T. MARTIN, T. B. KNUDSEN, A. M. RICHARD, M. POLOKOFF, J. YANG, E. BERG, R. J. KAVLOCK, AND D. J. DIX. Biological profiling of the ToxCast Phase II Chemical Library in Primary Human Cell Co-Culture Systems. Presented at The Society of Toxicology (SOT) 51st Annual Meeting and ToxExpo 2012, Moscone Convention Center, San Francisco, CA, March 11 - 15, 2012.

ROTROFF, D., R. JUDSON, D. REIF, M. T. MARTIN, A. M. RICHARD, K. A. HOUCK, C. JIN, Y. ABASSI, AND D. J. DIX. Characterizing the Estrogenic Potential of 1060 Environmental Chemicals by Assessing Growth Kinetics in T47D Cells. Presented at The Society of Toxicology (SOT) 51st Annual Meeting and ToxExpo 2012, Moscone Convention Center, San Francisco, CA, March 11 - 15, 2012.

ROTROFF, D., D. REIF, M. T. MARTIN, K. A. HOUCK, C. JIN, Y. A. ABASSI, M. STAMPFL, AND R. JUDSON. Characterizing the Growth Kinetics in Estrogen Responsive T47D Cells After Exposure to 2000 Environmental Chemicals . Presented at Roche Applied Sciences xCELLigence Symposium, Boston, MA, June 06 - 08, 2012.

MARTIN, M. T., T. B. KNUDSEN, R. JUDSON, R. J. KAVLOCK, AND D. J. DIX. Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program . Stephen A. Krawetz (Editor-in-Chief) (ed.), Systems Biology in Reproductive Medicine. Informa Healthcare USA, New York, NY, 58(1):3-9, (2012).

VOLARATH, P., M. T. MARTIN, AND A. M. RICHARD. Extending the Derek-Meteor Workflow to Predict Chemical-Toxicity Space Impacted by Metabolism: Application to ToxCast and Tox21 Chemical Inventories. Presented at The Society of Toxicology (SOT) 51st Annual Meeting and ToxExpo 2012, Moscone Convention Center, San Francisco, CA, March 11 - 15, 2012.

DIX, D. J., K. A. HOUCK, R. JUDSON, N. KLEINSTREUER, T. B. KNUDSEN, M. T. MARTIN, D. REIF, A. M. RICHARD, N. SIPES, AND R. J. KAVLOCK. HIGH THROUGHPUT ASSESSMENTS OF CONVENTIONAL AND ALTERNATIVE COMPOUNDS. Presented at The Society of Toxicology (SOT) 51st Annual Meeting and ToxExpo 2012, Moscone Convention Center, San Francisco, CA, March 11 - 15, 2012.

WILSON, A., M. T. MARTIN, A. FRAME, P. KOTHIYA, R. JUDSON, A. M. RICHARD, A. MEDVEDEV, S. MAKAROV, K. A. HOUCK, AND D. REIF. HIGH-DIMENSIONAL PROFILING OF TRANSCRIPTION FACTOR ACTIVITY DIFFERENTIATES TOXCAST CHEMICAL GROUPS. Presented at The Society of Toxicology (SOT) 51st Annual Meeting and ToxExpo 2012, Moscone Convention Center, San Francisco, CA, March 11 - 15, 2012.

KLEINSTREUER, N., D. J. DIX, K. A. HOUCK, R. J. KAVLOCK, T. B. KNUDSEN, M. T. MARTIN, K. B. PAUL, D. REIF, K. M. CROFTON, K. HAMILTON, R. HUNTER, I. A. SHAH, AND R. JUDSON. In vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis. TOXICOLOGICAL SCIENCES. Oxford University Press, Cary, NC, Epub(Advance Access):1-44, (2012).

DIX, D. J., K. A. HOUCK, R. JUDSON, N. KLEINSTREUER, T. B. KNUDSEN, M. T. MARTIN, D. REIF, A. M. RICHARD, I. A. SHAH, N. SIPES, AND R. J. KAVLOCK. Incorporating Biological, Chemical and Toxicological Knowledge into Predictive Models of Toxicity: Letter to the Editor. TOXICOLOGICAL SCIENCES. Oxford University Press, Cary, NC, 130(2):440-441, (2012).

SIPES, N. S., M. T. MARTIN, AND T. B. KNUDSEN. Species-Specific Predictive Signatures of Developmental Toxicity Using the ToxCast Chemical Library. Presented at 52nd Annual Meeting of The Teratology Society, Marriott Baltimore Waterfront Hotel, Baltimore, MD, June 23 - 27, 2012.

ROTROFF, D. M., D. J. DIX, K. A. HOUCK, T. B. KNUDSEN, M. T. MARTIN, K. M. MCLAURIN, D. M. REIF, K. M. CROFTON, A. V. SINGH, M. XIA, R. HUANG, AND R. S. JUDSON. Using in Vitro High Throughput Screening Assays to Identify Potential Endocrine-Disrupting Chemicals. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, Open Access(Epub):1-39, (2012).