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Records 1 to
25
of 72 records from author Hisham El-Masri
2023
El-Masri, H. A biologically based model to quantitatively assess the role of the nuclear receptors liver X (LXR), and pregnane X (PXR) on chemically induced hepatic steatosis (MIDD 2023). Model Informed Drug Design, Virtual, NC, February 15, 2023. https://doi.org/10.23645/epacomptox.22104860
Decrane, R., T. Stoker, A. Murr, J. Ford, AND H. El-Masri. Cross species extrapolation of the disruption of thyroid hormone synthesis by oxyfluorfen using in vitro data, physiologically based pharmacokinetic (PBPK), and thyroid hormone kinetics models. Current Research in Toxicology. Elsevier B.V., Amsterdam, Netherlands, 5:100138, (2023). https://doi.org/10.1016/j.crtox.2023.100138
Douillet, C., M. Miller, P. Cable, Q. Shi, H. El-Masri, T. Matousek, B. Koller, D. Thomas, AND M. Styblo. Fate of arsenicals in mice carrying the human AS3MT gene exposed to environmentally relevant levels of arsenite in drinking water. Scientific Reports. Nature Publishing Group, London, Uk, 13(1):3660, (2023). https://doi.org/10.1038/s41598-023-30723-8
Decrane, R., T. Stoker, A. Murr, J. Ford, AND H. El-Masri. In vitro to In vivo (IVIVE) and Species Extrapolation for the Disruption of Thyroid Hormone Synthesis by Oxyfluorfen using Physiologically Based Pharmacokinetic (PBPK) and Thyroid Hormones Kinetics Models. SOT, Nashville, TN, March 19 - 23, 2023. https://doi.org/10.23645/epacomptox.22211938
El-Masri, H. Practical Reproductive and Developmental Toxicology, PK/ADME of Xenobiotics/Chemicals during Pregnancy/Lactation and in Fetus/Newborn. ACT/BDRP Education Course, Gaithersburg, MD, May 22 - 26, 2023. https://doi.org/10.23645/epacomptox.23526957
2022
Bay, C. AND H. El-Masri. A biologically based model to quantitatively assess the role of the nuclear receptors liver X (LXR), and pregnane X (PXR) on chemically induced hepatic steatosis. TOXICOLOGY LETTERS. Elsevier Science Ltd, New York, NY, 359(15):46-54, (2022). https://doi.org/10.1016/j.toxlet.2022.02.002
El-Masri, H., K. Paul-Friedman, K. Isaacs, AND B. Wetmore. Advances in computational methods along the exposure to toxicological response paradigm. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, 450:116141, (2022). https://doi.org/10.1016/j.taap.2022.116141
2021
Bay, C., Mary E. Gilbert, AND H. El-Masri. Integrative Life-Stage Physiologically Based Pharmacokinetic (PBPK) and Thyroid Hormones Kinetics Model for In Vitro to In Vivo (IVIVE) Extrapolation of Thyroid High Throughput (HTP) Assays. Society of Toxicology 2021 Virtual Annual meeting, Virtual, Florida, March 12 - 26, 2021. https://doi.org/10.23645/epacomptox.16834516
Handa, S., I. Hassan, Mary E. Gilbert, AND H. El-Masri. Mechanistic Computational Model for Extrapolating In vitro Thyroid Peroxidase (TPO) Inhibition Data to Predict Serum Thyroid Hormone Levels in Rats. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 183(1):36-48, (2021). https://doi.org/10.1093/toxsci/kfab074
Niyonzima, Y., H. Tran, AND H. El-Masri. Quantitative Systems Toxicology (QST) Model for Hepatic Steatosis Induction by Carbon Tetrachloride (CCl4). Society of Toxicology 2021 Virtual Annual meeting, Virtual, NC, March 12 - 26, 2021. https://doi.org/10.23645/epacomptox.14502150
2020
Hassan, I., H. El-Masri, J. Ford, A. Brennan, S. Handa, K. Friedman, AND M. Gilbert. Extrapolating In Vitro Screening Assay Data for Thyroperoxidase Inhibition to Predict Serum Thyroid Hormones in the Rat. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 173(2):280-292, (2020). https://doi.org/10.1093/toxsci/kfz227
Hill, T., J. Rooney, J. Abedini, H. El-Masri, C. Wood, AND Jon Corton. Gene Expression Thresholds Derived From Short-term Exposures Identify Rat Liver Tumorigens. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 177(1):41-59, (2020). https://doi.org/10.1093/toxsci/kfaa102
Corton, Jon, K. Korunes, J. Abedini, H. El-Masri, J. Brown, K. Friedman, Y. Liu, C. Martini, S. He, AND J. Rooney. Thresholds Derived from Common Measures in Rat Studies are Predictive of Liver Tumorigenic Chemicals. TOXICOLOGIC PATHOLOGY. Society of Toxicology, RESTON, VA, 48(7):857-874, (2020). https://doi.org/10.1177/0192623320960412
2019
Abedini, J. AND H. El-Masri. Identification of Differentially Expressed Genes (DEGs) and Networks Related to Hepatic Lipid Dysfunction. Society of Toxicology, Baltimore, Maryland, March 10 - 14, 2019.
Abedini, J., S. Handa, S. Edwards, B. Chorley, AND H. El-Masri. Identification of differentially expressed genes and networks related to hepatic lipid dysfunction. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, 382:114757, (2019). https://doi.org/10.1016/j.taap.2019.114757
Hassan, I., H. El-Masri, J. Ford, A. Brennan, S. Handa, AND M. Gilbert. In vitro to In vivo Extrapolation of High-throughput Screening Assay for Thyroperoxidase Inhibition. Society of Toxicology, Baltimore, Maryland, March 10 - 14, 2019.
2018
Hassan, I., H. El-Masri, J. Ford, S. Handa, AND M. Gilbert. Application of Physiologically-Based Pharmacokinetic/Pharmacodynamic Model for Interpretation of High-throughput Screening Assay for Thyroperoxidase Inhibition. Society of Toxicology Annual Meeting, San Antonio, TX, March 08 - 15, 2018.
El-Masri, H. Developmental and Life-Stage Physiologically-Based Pharmacokinetic (PBPK) Models in Humans and Animal Models. Society of Toxicology, San Antonio, Texas, March 11 - 15, 2018.
El-Masri, H., T. Hong, C. Henning, W. Mendez, E. Hudgens, D. Thomas, AND JaniceS Lee. Evaluation of a Physiologically based Pharmacokinetic (PBPK) Model for Inorganic Arsenic Exposure Using Data from Two Diverse Human Populations. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 126(7):1-18, (2018). https://doi.org/10.1289/EHP3096
Abedini, J., A. Walsh, AND H. El-Masri. Identification of Absorption, Distribution, Metabolism, and Excretion (ADME) Genes Relevant to Steatosis Using a Gene Expression Approach. Society of Toxicology, San Antonio, Texas, March 11 - 15, 2018.
Abedini, J. AND H. El-Masri. Identification of Differentially Expressed Genes (DEGs) and Networks Related to Hepatic Lipid Homeostatic Dysfunction Using a Gene Expression Approach. NCSOT, Durham, North Carolina, October 15, 2018.
Leonard, J., H. El-Masri, C. Stevens, K. Mansouri, AND C. Tan. Integrating Exposure, Pharmacokinetics, And Dosimetry With In Vitro Dose-Response Data To Evaluate Chemical Risk. 2018 SOT Annual Meeting and ToxExpo, San Antonio, TX, March 11 - 15, 2018.
2017
Leonard, J., D. Chang, H. El-Masri, S. Edwards, C. Stevens, K. Mansouri, P. Egeghy, AND C. Tan. A tiered approach for integrating exposure and dosimetry with in vitro dose-response data in the modern risk assessment paradigm. 254th ACS National Meeting & Exposition, Washington, DC, August 20 - 24, 2017.
Hassan, I., H. El-Masri, Pat Kosian, J. Ford, S. Degitz, AND M. Gilbert. Neurodevelopment and Thyroid Hormone Synthesis Inhibition in the Rat: Quantitative Understanding Within the Adverse Outcome Pathway Framework. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 160(1):57-73, (2017).
El-Masri, H., M. Jasper, AND M. Gilbert. Physiologically-Based Pharmacokinetic (PBPK) Model for the Thyroid Hormones in the Pregnant Rat and Fetus. Society of Toxicology, Baltimore, MD, March 12 - 16, 2017.