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Records 1 to 25 of 169 records from author Sigmund Degitz

2024
Judson, R., D. Smith, M. Devito, J. Wambaugh, B. Wetmore, K. Friedman, G. Patlewicz, R. Thomas, R. Sayre, J. Olker, S. Degitz, S. Padilla, J. Harrill, T. Shafer, AND K. Carstens. A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS). Society of Toxicology (SOT) 63rd Annual Meeting and ToxExpo, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25451677
Judson, R., D. Smith, M. Devito, J. Wambaugh, B. Wetmore, K. Friedman, G. Patlewicz, R. Thomas, R. Sayre, J. Olker, S. Degitz, S. Padilla, J. Harrill, T. Shafer, AND K. Carstens. A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS) (Toxics). Toxics. MDPI, Basel, Switzerland, 12(4):271, (2024). https://doi.org/10.3390/toxics12040271
2023
Haselman, Jonathan, J. Nichols, K. Mattingly, M. Hornung, AND S. Degitz. A biologically based computational model for the hypothalamic-pituitary-thyroid (HPT) axis in Xenopus laevis larvae. MATHEMATICAL BIOSCIENCES. Elsevier Science Ltd, New York, NY, 362:109021, (2023). https://doi.org/10.1016/j.mbs.2023.109021
Eytcheson, S., J. Olker, K. Paul-Friedman, M. Hornung, AND S. Degitz. Assessing the Predictive Value of Thyroid In Vitro Screening Assays Through Comparisons to Observed Impacts In Vivo. SETAC North America, Louisville, KY, November 12 - 16, 2023. https://doi.org/10.23645/epacomptox.25114523
Eytcheson, S., J. Olker, K. Friedman, M. Hornung, AND S. Degitz. Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 144:105491, (2023). https://doi.org/10.1016/j.yrtph.2023.105491
Eytcheson, Stephanie A., A. Zosel, M. Hornung, AND S. Degitz. Identifying Thyroid-Active Chemicals Using High-Throughput Screening. SOT, Nashville, TN, March 19 - 23, 2023. https://doi.org/10.23645/epacomptox.24299056
Degitz, S., J. Olker, J. Denny, P. Degoey, P. Hartig, M. Cardon, S. Eytcheson, Jonathan Haselman, S. Mayasich, AND M. Hornung. In vitro screening of per- and polyfluorinated substances (PFAS) for interference with seven thyroid hormone system targets across nine assays. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 95:105762, (2024). https://doi.org/10.1016/j.tiv.2023.105762
2022
Haselman, Jonathan, J. Olker, P. Kosian, J. Korte, J. Denny, J. Tietge, M. Hornung, AND S. Degitz. Characterization of the Mechanistic Linkages Between Iodothyronine Deiodinase Inhibition and Impaired Thyroid-Mediated Growth and Development in Xenopus Laevis Using Iopanoic Acid. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 187(1):139-149, (2022). https://doi.org/10.1093/toxsci/kfac014
Olker, J., J. Korte, Jonathan Haselman, M. Hornung, AND S. Degitz. Cross-species comparison of chemical inhibition of human and Xenopus iodotyrosine deiodinase. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 249:106227, (2022). https://doi.org/10.1016/j.aquatox.2022.106227
Eytcheson, S., M. Hornung, AND S. Degitz. Utilizing High-Throughput Screening to Rank and Prioritize Thyroid-Active Chemicals. SETAC North America, Pittsburgh, PA, November 13 - 17, 2022. https://doi.org/10.23645/epacomptox.21554871
2021
Mayasich, S., P. Degoey, J. Haselman, AND S. Degitz. DEVELOPMENT OF TYPE 2 AND TYPE 3 IODOTHYRONINE DEIODINASE KNOCKOUT XENOPUS TROPICALIS USING CRISPR/CAS12A GENE EDITING. North American Society for Comparative Endocrinology (NASCE) 6th biennial meeting, Duluth, MN, May 25 - 27, 2021. https://doi.org/10.23645/epacomptox.14627562
Olker, J., J. Korte, J. Denny, J. Haselman, Philip Hartig, M. Cardon, M. Hornung, AND S. Degitz. In Vitro Screening for Chemical Inhibition of the Iodide Recycling Enzyme, Iodotyrosine Deiodinase. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 71:105073, (2021). https://doi.org/10.1016/j.tiv.2020.105073
Mayasich, S., J. Korte, J. Denny, Philip Hartig, J. Olker, P. Degoey, J. O'Flanagan, S. Degitz, AND M. Hornung. Xenopus laevis and human type 3 iodothyronine deiodinase enzyme cross-species sensitivity to inhibition by ToxCast chemicals. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 73:105141, (2021). https://doi.org/10.1016/j.tiv.2021.105141
2020
Olker, J., J. Korte, J. Haselman, M. Hornung, AND S. Degitz. Chemical Inhibition of the Iodide Recycling Enzyme Iodotyrosine Deiodinase, with Human and Xenopus Compariso. SETAC North America, Fort Worth, TX, November 15 - 19, 2020. https://doi.org/10.23645/epacomptox.13114172
Haselman, Jonathan, J. Olker, P. Kosian, J. Korte, J. Swintek, J. Denny, J. Nichols, J. Tietge, M. Hornung, AND S. Degitz. Targeted pathway-based in vivo testing using thyroperoxidase inhibition to evaluate plasma thyroxine as a surrogate metric of metamorphic success in model amphibian Xenopus laevis. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 175(2):236-250, (2020). https://doi.org/10.1093/toxsci/kfaa036
2019
Mayasich, S., J. Denny, J. Korte, P. Kosian, J. Olker, P. Degoey, J. O'Flanagan, S. Degitz, AND M. Hornung. Characterization of Xenopus laevis iodothyronine deiodinase (DIO3) enzyme and chemical inhibition comparison with human DIO3. North American Society for Comparative Endocrinology, Gainsville, FL, May 24 - 28, 2019.
Noyes, Pamela, K. Friedman, P. Browne, Jonathan Haselman, M. Gilbert, M. Hornung, Stanley Barone, K. Crofton, S. Laws, T. Stoker, S. Simmons, J. Tietge, AND S. Degitz. Evaluating chemicals for thyroid disruption: opportunities and challenges with in vitro testing and adverse outcome pathway approaches. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 127(9):095001, (2019). https://doi.org/10.1289/EHP5297
Mayasich, S., J. Denny, J. Korte, J. Olker, P. Degoey, J. O'Flanagan, S. Degitz, AND M. Hornung. Human and Xenopus laevis type 3 iodothyronine deiodinase enzyme cross-species sensitivity to inhibition by ToxCast chemicals. SETAC North America, Toronto, ON, CANADA, November 03 - 07, 2019.
Olker, J., Joe Korte, J. Denny, P. Hartig, M. Cardon, J. O'Flanagan, M. Hornung, AND S. Degitz. In vitro screening assays for chemical inhibition of mammalian and amphibian iodotyrosine deiodinase. Society of Toxicology, Baltimore, MD, March 10 - 14, 2019.
Olker, J., Jonathan Haselman, J. Korte, J. Denny, P. Hartig, M. Cardon, J. O'Flanagan, P. Degoey, M. Hornung, AND S. Degitz. Screening for chemical inhibition of the iodide recycling enzyme, a novel molecular target for thyroid axis disruption. SETAC North America, Toronto, ON, CANADA, November 03 - 07, 2019.
Olker, J., Joe Korte, J. Denny, P. Hartig, M. Cardon, C. Knutsen, P. Kent, J. Christensen, S. Degitz, AND M. Hornung. Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 168(2):430-442, (2019). https://doi.org/10.1093/toxsci/kfy302
Riutta, C., I. Hassan, J. Ford, P. Kosian, Katherine OShaughnessy, S. Degitz, AND M. Gilbert. Thyroid Hormone Measurements in Rat Brain by Mass Spectrometry. Developmental Neurotoxicology Society (DNTS), San Diego, CA, June 23 - 26, 2019.
2018
Gilbert, M., R. Ford, S. Thomas, S. Spring, W. Oshiro, Pat Kosian, J. Ford, AND S. Degitz. Cortical Brain Malformation and Learning Impairments Induced by Developmental Thyroid Hormone Insufficiency: A Cross-Fostering Study. SOT, Baltimore, MD, March 12 - 16, 2017.
LaLone, C., Dan Villeneuve, J. Doering, B. Blackwell, S. Degitz, A. Williams, AND G. Ankley. Defining the taxonomic domain of applicability for mammalian-based high-throughput screening assays. SETAC Focused Topic, Durham, NC, April 16 - 18, 2018.