Science Inventory

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Brennan, A., D. Chang, J. Cowden, S. Davidson-Fritz, J. Dean, M. Devito, J. Ford, L. Everett, A. Harrill, S. Hester, M. Hughes, J. Lambert, L. Lizarraga, R. Mezencev, D. Macmillan, G. Patlewicz, Kristina Chialton, R. Thomas, K. Vitense, L. Wehmas, A. Renyer, S. Auerbach, AND W. Casey. EPA Transcriptomic Assessment Product (ETAP) for Perfluoro-3-Methoxypropanoic Acid. U.S. Environmental Protection Agency, Washington, DC, EPA/600/X-24/066, 2024. https://doi.org/10.23645/epacomptox.25352962

Chang, D., J. Cowden, S. Davidson-Fritz, J. Dean, M. Devito, L. Everett, A. Harrill, S. Hester, M. Hughes, J. Lambert, L. Lizarraga, R. Mezencev, G. Patlewicz, R. Thomas, L. Wehmas, K. Vitense, S. Auerbach, W. Casey, R. Sams, S. Hunter, J. Bucher, T. Buckley, P. Egeghy, K. Paul-Friedman, J. Harrill, K. Isaacs, R. Judson, J. Kaiser, S. Masten, F. Parham, D. Petersen, A. Phillips, J. Sobus, Dan Villeneuve, P. White, A. Williams, G. Woodall, AND J. Zhao. Scientific Studies Supporting Development of Transcriptomic Points of Departure for EPA Transcriptomic Assessment Products (ETAPs). U.S. Environmental Protection Agency, Washington, DC, EPA/600/X-23/084, 2024. https://doi.org/10.23645/epacomptox.25365550

Brennan, A., D. Chang, J. Cowden, S. Davidson-Fritz, J. Dean, M. Devito, J. Ford, L. Everett, A. Harrill, S. Hester, M. Hughes, J. Lambert, L. Lizarraga, R. Mezencev, D. Macmillan, G. Patlewicz, K. Thayer, R. Thomas, K. Vitense, L. Wehmas, A. Renyer, S. Auerbach, W. Casey, R. Sams, S. Hunter, W. Cascio, K. Holt, S. Jones, R. Subramaniam, G. Rice, J. Bucher, T. Buckley, P. Egeghy, K. Paul-Friedman, J. Harrill, K. Isaacs, R. Judson, J. Kaiser, S. Masten, F. Parham, D. Petersen, A. Phillips, J. Sobus, Dan Villeneuve, P. White, A. Williams, G. Woodall, AND J. Zhao. Standard Methods for Development of EPA Transcriptomic Assessment Products (ETAPs). U.S. Environmental Protection Agency, Washington, DC, EPA/600/X-23/083, 2024. https://doi.org/10.23645/epacomptox.25365496

Wehmas, L., K. Flynn, M. Hazemi, S. Hester, AND Dan Villeneuve. Gene Expression-Based Dose Response Analysis of Short-Term Rat and Fathead Minnow Exposures to Two Metal Sulfates Indicates Chronic Chemical Potency. SETAC, Louisville, KY, November 12 - 16, 2023. https://doi.org/10.23645/epacomptox.24794595

Martin, R., S. Hester, M. Hazemi, K. Flynn, Dan Villeneuve, AND L. Wehmas. Short-term transcriptomic points-of-departure are consistent with their chronic points-of departure for three organophosphate pesticides. SOT, Nashville, TN, March 19 - 23, 2023. https://doi.org/10.23645/epacomptox.22596343

Wehmas, L. AND S. Hester. Toxicogenomic analysis of >25-year-old archival tissue samples indicate metal sulfate mode of action and potency. SOT, Nashville, TN, March 19 - 23, 2023. https://doi.org/10.23645/epacomptox.22630594

Mills, M., E. Bruce, M. Huang, J. Crothers, O. Hyrien, C. Oura, L. Blake, A. Brown Jordan, S. Hester, L. Wehmas, B. Mari, P. Barby, C. Lacoux, J. Fassy, P. Vial, C. Vial, J. Martinez, O. Oladipo, B. Inuwa, I. Shittu, C. Meseko, R. Chammas, C. Santos, T. Dionísio, T. Garbieri, V. Parisi, M. Mendes-Correa, A. dePaula, C. Romano, L. Góes, P. Minoprio, A. Campos, M. Cunha, A. Vilela, T. Nyirenda, R. Mkakosya, A. Muula, R. Dumm, R. Harris, C. Mitchell, S. Pettit, J. Botten, AND K. Jerome. An international, interlaboratory ring trial confirms the feasibility of an extraction-less “direct” RT-qPCR method for reliable detection of SARS-CoV-2 RNA in clinical samples. PLOS ONE . Public Library of Science, San Francisco, CA, 17(1):e0261853, (2022). https://doi.org/10.1371/journal.pone.0261853

Cannizzo, M., C. Wood, S. Hester, AND L. Wehmas. Case study: Targeted RNA-sequencing of aged formalin-fixed paraffin-embedded samples for understanding chemical mode of action. Toxicology Reports. Elsevier B.V., Amsterdam, Netherlands, 9:883-894, (2022). https://doi.org/10.1016/j.toxrep.2022.04.012

Conley, J., C. Lambright, N. Evans, E. Medlock Kakaley, D. Jenkins-Hill, J. McCord, M. Strynar, L. Wehmas, S. Hester, D. Macmillan, AND L. Gray. Developmental toxicity of Nafion byproduct 2 (NBP2) in the Sprague-Dawley rat with comparisons to hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) and perfluorooctane sulfonate (PFOS). ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, Netherlands, 160:107056, (2022). https://doi.org/10.1016/j.envint.2021.107056

Marable, C., C. Frank, R. Seim, S. Hester, Matt Henderson, B. Chorley, AND T. Shafer. Integrated Omic Analyses Identify Pathways and Transcriptomic Regulators Associated with Chemical Alterations of in vitro Neural Network Formation. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 186(1):118-133, (2022). https://doi.org/10.1093/toxsci/kfab151

Wehmas, L., C. Wood, P. Guan, M. Gosink, AND S. Hester. Organocatalyst treatment improves variant calling and mutant detection in archival clinical samples. Scientific Data. Springer Nature, New York, NY, 12:6509, (2022). https://doi.org/10.1038/s41598-022-10301-0

Martin, R., S. Hester, AND L. Wehmas. Short-Term Transcriptomic Points-of-Departure are Consistent with Chronic Points-of-Departure for Three Organophosphate Pesticides in Rodents. ASCCT, Chapel Hill, NC, October 19 - 21, 2022. https://doi.org/10.23645/epacomptox.21824532

Franzosa, J., J. Bonzo, J. Jack, Nancy C. Baker, P. Kothiya, R. Witek, P. Hurban, S. Siferd, S. Hester, I. Shah, S. Ferguson, K. Houck, AND J. Wambaugh. High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures. npj Systems Biology and Applications. Springer Nature, New York, NY, 7:Article 7, (2021). https://doi.org/10.1038/s41540-020-00166-2

Pettit, S., K. Jerome, D. Rouquié, B. Mari, P. Barbry, Y. Kanda, M. Matsumoto, S. Hester, L. Wehmas, J. Botten, AND E. Bruce. 'All In': a pragmatic framework for COVID-19 testing and action on a global scale. EMBO Molecular Medicine. EMBO Press, Heidelberg, Germany, 12(6):e12634, (2020). https://doi.org/10.15252/emmm.202012634

Wehmas, L., S. Hester, AND C. Wood. Direct Formalin Fixation Induces Widespread Transcriptomic Effects in Archival Tissue Samples. Scientific Reports. Nature Publishing Group, London, Uk, 10:14497, (2020). https://doi.org/10.1038/s41598-020-71521-w

Malloy, M., G. Carswell, B. Bennet, P. Bushel, L. Wehmas, S. Hester, AND B. Chorley. Establishing methods to assess epigenetic signatures in archived study tissues. 2020 SOT Annual Meeting, Research Triangle Park, NC, March 15 - 19, 2020. https://doi.org/10.23645/epacomptox.14340239

Wehmas, L., S. Hester, AND C. Wood. Genomics in formalin-fixed paraffin embedded tissue (FFPE) samples for quantitative risk assessment. HESI eSTAR Webinar, RTP, NC, May 26, 2020. https://doi.org/10.23645/epacomptox.18162857

Cannizzo, M., S. Hester, L. Wehmas, K. Bailey, D. Cowie, AND R. Currie. Transcriptional profiling informs target organ phenotypic responses of agrochemicals in rats. Genetics and Environmental Mutagenesis Society (GEMS) Spring 2020 Virtual Symposium, Virtual, North Carolina, May 12, 2020. https://doi.org/10.23645/epacomptox.12505454

Cannizzo, M., L. Wehmas, K. Bailey, D. Cowie, R. Currie, AND S. Hester. Transcriptional profiling informs target organ phenotypic responses of agrochemicals in rats (SOT 2020). 59th Annual Society of Toxicology (SOT) meeting, Anaheim, CA, March 15 - 19, 2020. https://doi.org/10.23645/epacomptox.12933878

Wehmas, L., C. Wood, AND S. Hester. Transcriptomic dose response modeling in >21 year-old archival mouse liver tissue for risk assessment. Society of Toxicology, Anaheim, CA, March 15 - 19, 2020. https://doi.org/10.23645/epacomptox.19103639

Chorley, B. AND S. Hester. Editorial overview: “Toxico-omic” Distillation for Regulatory Application in Human Health. Current Opinion in Toxicology. Elsevier BV, AMSTERDAM, Netherlands, 18:iii-vi, (2019). https://doi.org/10.1016/j.cotox.2019.09.007

Wehmas, L., C. Wood, B. Chorley, C. Yauk, G. Nelson, AND S. Hester. Enhanced Quality Metrics for Assessing RNA Derived From Archival Formalin-Fixed Paraffin-Embedded Tissue Samples. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 170(2):357-373, (2019). https://doi.org/10.1093/toxsci/kfz113

Marable, C., B. Chorley, W. Henderson, S. Hester, AND T. Shafer. Integrated -OMIC Analysis Following Chemical-Induced Alterations of Neural Network Formation in Vitro. International Neurotoxicology Meeting, Dusseldorf, GERMANY, September 29 - October 03, 2019.

Wehmas, L., C. Wood, AND S. Hester. Characterizing Genomic Effects of Formalin Fixation in Archival Samples. North Carolina Biotechnology Center, RTP, North Carolina, July 11 - 12, 2018.

Carswell, G., L. Wehmas, S. Hester, B. Vallanat, J. Chamberlin, C. Wood, B. Chorley, AND B. Bennett. DNA Methylation Alterations Associated with Latent Carcinogenic Activity of Dichloroacetic Acid in Mice. DNA and RNA Methylation - Keystone Symposia, Vancouver, British Columbia, CANADA, January 21 - 26, 2018.