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Records 1 to 25 of 55 records from author Alex Hoffman

2023
Nichols, J., P. Fitzsimmons, A. Hoffman, AND K. Wong. In vitro-in vivo extrapolation of hepatic biotransformation data for fish. III. An in-depth case study with pyrene. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 42(7):1501-1515, (2023). https://doi.org/10.1002/etc.5626
2021
Nichols, J., A. Hoffman, J. Swintek, S. Droge, AND P. Fitzsimmons. Addition of phenylmethylsulfonyl fluoride (PMSF) substantially increases the working lifetime of the trout liver S9 substrate depletion assay resulting in improved detection of low intrinsic clearance rates. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 40(1):148-161, (2021). https://doi.org/10.1002/etc.4901
2020
Saunders, L., A. Hoffman, J. Nichols, AND F. Gobas. Dietary bioaccumulation and biotransformation of hydrophobic organic sunscreen agents in rainbow trout. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 39(3):574-586, (2020). https://doi.org/10.1002/etc.4638
2019
Nichols, J., M. Ladd, A. Hoffman, AND P. Fitzsimmons. Biotransformation of pollycyclic aromatic hydrocarbons by trout liver S9 fractions: Evaluation of competitive inhibition using a substrate depletion approach. Fish Biotransformation in Bioaccumulation: Technical Workshop, sponsored by HESI, Washington, D.C, October 01 - 03, 2019.
Nichols, J., M. Ladd, A. Hoffman, AND P. Fitzsimmons. Biotransformation of polycyclic aromatic hydrocarbons by trout liver S9 fractions: Evaluation of competitive inhibition using a substrate depletion approach. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 38(12):2729-2739, (2019). https://doi.org/10.1002/etc.4595
2018
Fitzsimmons, P., A. Hoffman, K. Fay, AND J. Nichols. Allometric scaling of hepatic biotransformation in rainbow trout. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY - PART C: TOXICOLOGY & PHARMACOLOGY . Elsevier Science Ltd, New York, NY, 214:52-60, (2018). https://doi.org/10.1016/j.cbpc.2018.08.004
Saunders, L., A. Hoffman, P. Fitzsimmons, J. Nichols, AND F. Gobas. Quantitative in vitro - in vivo extrapolation of biotransformation rates for bioaccumulation assessment: Focus on organic sunscreen agents in trout. SETAC North America, Sacramento, CA, November 04 - 08, 2018.
Frew, J., J. Brown, P. Fitzsimmons, A. Hoffman, M. Sadilek, C. Grue, AND J. Nichols. Toxicokinetics of the neonicotinoid insecticide imidacloprid in rainbow trout (Oncorhynchus mykiss). COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY - PART C: TOXICOLOGY & PHARMACOLOGY . Elsevier Science Ltd, New York, NY, 205:34-42, (2018).
2017
Fitzsimmons, P., A. Hoffman, K. Fay, AND J. Nichols. Allometric scaling of hepatic biotransformation in rainbow trout. SETAC North America, Minneapolis, MN, November 12 - 16, 2017.
Fay, K., P. Fitzsimmons, A. Hoffman, AND J. Nichols. Comparison of trout hepatocytes and liver S9 fractions as in vitro models for predicting hepatic clearance in fish. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 36(2):463-471, (2017).
2016
Fay, K., P. Fitzsimmons, A. Hoffman, AND J. Nichols. Comparison of trout hepatocytes and liver S9 fractions as in vitro models for predicting hepatic clearance in fish. setac north america, Orlando, FL, November 06 - 10, 2016.
Saunders, L., A. Hoffman, J. Nichols, AND F. Gobas. Concentration dependence of in vivo biotransformation rates of organic sunscreen agents in rainbow trout following a dietary exposure. SETAC North America, Orlando, FL, November 06 - 10, 2016.
Consoer, D., A. Hoffman, P. Fitzsimmons, Pat Kosian, AND J. Nichols. Toxicokinetics of perfluorooctane sulfonate in rainbow trout (Oncorhynchus mykiss). ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 35(3):717-727, (2016).
2015
Nichols, J., B. Du, R. Erickson, A. Hoffman, J. Berninger, C. Chambliss, K. Connors, AND B. Brooks. Observed and modeled effects of pH on bioconcentration of diphenhydramine, a weakly basic pharmaceutical, by fathead minnows. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 34(6):1425-1435, (2015).
2014
Fay, K., R. Mingoia, I. Goeritz, D. Nabb, A. Hoffman, B. Ferrell, H. Peterson, J. Nichols, H. Segner, AND X. Han. Intra- and inter-laboratory reliability of a cryopreserved trout hepatocyte assay for the prediction of chemical bioaccumulation potential. ENVIRONMENTAL SCIENCE AND TECHNOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 48(14):8170-8178, (2014).
Nichols, J., B. Du, J. Berninger, K. Connors, K. Chambliss, R. Erickson, A. Hoffman, AND B. Brooks. Observed and modeled effects of pH on bioconcentration of diphenhydramine, a weakly basic pharmaceutical, in fathead minnows. SETAC, Vancouver, BC, CANADA, November 09 - 13, 2014.
Fay, K., P. Fitzsimmons, A. Hoffman, AND J. Nichols. Optimizing the use of rainbow trout hepatocytes for bioaccumulation assessments with fish. XENOBIOTICA. Taylor & Francis, Inc., Philadelphia, PA, 44(4):345-351, (2014).
Consoer, D., A. Hoffman, P. Fitzsimmons, Pat Kosian, AND J. Nichols. Toxicokinetics of perfluorooctanoate (PFOA) in rainbow trout(Oncorhynchus mykiss). AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 156:65-73, (2014).
2013
Connors, K., B. Du, P. Fitzsimmons, A. Hoffman, C. Chambliss, J. Nichols, AND B. Brooks. Comparative pharmaceutical metabolism by rainbow trout (Oncorhynchus mykiss) liver S9 fractions. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 32(8):1810-1818, (2013).
Nichols, J., A. Hoffman, T. Ter Laak, AND P. Fitzsimmons. Hepatic clearance of 6 polyaromatic aromatic hydrocarbons by isolated trout livers: Prediction from in vitro clearance by liver S9 fractions. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 136(2):359-372, (2013).
Fitzsimmons, P., A. Hoffman, AND J. Nichols. Incremental improvements to the trout S9 biotransformation assay. Presented at SETAC, Nashville, TN, November 17 - 21, 2013.
Fay, K., R. Mingoia, I. Goeritz, D. Nabb, A. Hoffman, B. Ferrell, H. Peterson, J. Nichols, H. Segner, AND X. Han. Inter-laboratory comparison of clearance rates of xenobiotics by cryopreserved trout hepatocytes for the prediction of bioaccumulation potential. Presented at Society of Toxicology, March 10 - 14, 2013.
Fay, K., R. Mingoia, I. Goeritz, D. Nabb, A. Hoffman, B. Ferrell, H. Peterson, J. Nichols, H. Segner, AND X. Han. Inter-laboratory comparison of xenobiotic clearance rates determined using cryopreserved trout hepatocytes for improving bioaccumulation predictions. Presented at Health and Environmental Sciences Institute, Duluth, MN, November 01, 2013.
Fay, K., P. Fitzsimmons, A. Hoffman, AND J. Nichols. Use of isolated hepatocytes to predict measured hepatic clearance of five polyaromatic hydrocarbons by perfused trout livers. Presented at Society of Toxicology, March 10 - 14, 2013.
2012
Nichols, J., A. Hoffman, P. Fitzsimmons, K. Fay, AND T. Ter Laak. Predicting the accumulation of well-metabolized chemicals by fish from measured rates of in vitro intrinsic clearance: Progress made and challenges ahead. Presented at Invited oral presentation, Stockholm University.