Science Inventory

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Fitzpatrick, H., K. Wallace, T. Freudenrich, M. Mayil Vahanan, AND K. Carstens. Characterization of signaling pathways in in vitro developmental neurotoxicity battery. SOT Conference 2024: A New Approach Method (NAM) to Screen for the Impact of Endogenous Stress on Chemical Toxicity, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25431925

Rice, O., Q. Krantz, E. Puckett, P. Evansky, K. Wallace, T. Freudenrich, M. Higuchi, AND T. Shafer. Development Of A Novel in Vitro Method to Study Effects of Volatile Compounds on Neural Activity. Society of Toxicology (SOT) 63rd Annual Meeting and ToxExpo, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25407025

Shafer, T., T. Freudenrich, K. Wallace, M. Mayil Vahanan, AND K. Carstens. Re-testing of false negative compounds in new approach methods (NAMs) for developmental neurotoxicity screening. SOT Conference 2024: A New Approach Method (NAM) to Screen for the Impact of Endogenous Stress on Chemical Toxicity, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25544425

Carstens, K., T. Freudenrich, K. Wallace, S. Choo, A. Carpenter, A. Richard, G. Patlewicz, B. Wetmore, K. Friedman, AND T. Shafer. Evaluation of Per- and Poly fluoroalkyl Substances (PFAS) in vitro toxicity testing for developmental neurotoxicity (SOT 2023). Presented at Society of Toxicology 62nd Annual Meeting and ToxExpo 2023, Nashville, TN, March 19 - 23, 2023. https://doi.org/10.23645/epacomptox.22714213

Carstens, K., T. Freudenrich, K. Wallace, S. Choo, A. Carpenter, M. Smeltz, M. Clifton, Matthew Henderson, A. Richard, G. Patlewicz, B. Wetmore, K. Friedman, AND T. Shafer. Evaluation of Per- and Polyfluoroalkyl Substances (PFAS) In Vitro Toxicity Testing for Developmental Neurotoxicity. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 36(3):402-419, (2023). https://doi.org/10.1021/acs.chemrestox.2c00344

Byrd, G., T. Freudenrich, S. Choo, M. Culbreth, T. Shafer, AND J. Harrill. Increasing the Throughput of a High-Content Imaging-Based Developmental Neurotoxicity Proliferation Assay. International Neurotoxicology Association (INA), Durham, NC, May 21 - 25, 2023. https://doi.org/10.23645/epacomptox.23148746

Choo, S., K. Wallace, T. Freudenrich, AND T. Shafer. 03222022-Electrical Impedance for non-destructive, real time measurement of neural cell viability on microelectrode Arrays (Abstract for SOT 22). Society of Toxicology 61st Annual Meeting and ToxExpo 2022, San DIego, California, March 27 - 31, 2022. https://doi.org/10.23645/epacomptox.19415969

Choo, S., K. Wallace, T. Freudenrich, AND T. Shafer. Electrical Impedance for Non-Destructive, Real Time Measurement of Neural Cell Viability on Microelectrode Arrays. Society of Toxicology 61st Annual Meeting and ToxExpo 2022, San Diego, CA, March 27 - 31, 2022. https://doi.org/10.23645/epacomptox.19415969

Carstens, K., T. Freudenrich, K. Wallace, S. Choo, A. Carpenter, A. Richard, G. Patlewicz, B. Wetmore, K. Paul-Friedman, AND T. Shafer. Evaluation of Per- and Poly fluoroalkyl Substances (PFAS) in vitro toxicity testing for developmental neurotoxicity. American Society for Cellular and Computational Toxicology (ASCCT) Conference, Durham, NC, October 19 - 21, 2022. https://doi.org/10.23645/epacomptox.21859527

Gallegos, D., C. Marable, B. Chorley, K. Wallace, T. Freudenrich, AND T. Shafer. Integration of Genomic Data Streams in an In Vitro Network Development Model. Society of Toxicology 2021 Virtual Annual Meeting, Virtual, North Carolina, March 12 - 26, 2021. https://doi.org/10.23645/epacomptox.14466096

Millard, D., A. Nicolini, C. Arrowood, J. Bradley, C. Strock, T. Freudenrich, K. Wallace, Tim Shafer, M. Cato, L. Saavedra, D. Haag, T. Feaster, B. Anson, G. Luerman, D. Hess, Y. Shi, J. Li, H. Shi, P. Levesque, M. Kreir, H. Lu, I. Suzuke, A. Odawara, Y. Kanda, D. Herr, R. Roberts, AND J. Pierson. Evaluating the use of microelectrode array technology and cell-based neuronal culture models for proconvulsant risk assessment: progress from the HESI NeuTox Consortium. Safety Pharmacology Society, Washi, District Of Columbia, September 30 - October 03, 2018.

Harrill, J., T. Freudenrich, K. Wallace, K. Ball, Tim Shafer, AND W. Mundy. Testing for developmental neurotoxicity using a battery of in vitro assays for key cellular events in neurodevelopment. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, 354(1):24-39, (2018). https://doi.org/10.1016/j.taap.2018.04.001

Freudenrich, T., K. Wallace, D. Haag, L. Saavedra, W. Mundy, J. Davila, T. Sudof, M. Wernig, AND Tim Shafer. Comparison of acute effects of neurotoxic compounds in neural networks from rodent and human neurons using microelectrode arrays. Society of Toxicology 2017 Annual Meeting, Baltimore, Maryland, March 12 - 16, 2017.

Druwe, I., T. Freudenrich, K. Wallace, Tim Shafer, AND W. Mundy. Comparison of Human Induced Pluripotent Stem Cell-Derived Neurons and Rat Primary CorticalNeurons as In Vitro Models of Neurite Outgrowth. Applied In Vitro Toxicology. Mary Ann Liebert, Inc., Larchmont, NY, 2(1):26-36, (2016).

Harrill, J., B. Robinette, T. Freudenrich, AND W. Mundy. Media formulation influences chemical effects on neuronal growth and morphology. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY - ANIMAL. Society for In Vitro Biology-Animal, 51(6):612-29, (2015).

Druwe, I., T. Freudenrich, K. Wallace, Tim Shafer, AND W. Mundy. Sensitivity of neuroprogenitor cells to chemical-induced apoptosis using a multiplexed assay suitable for high-throughput screening*. TOXICOLOGY. Elsevier Science Ltd, New York, NY, 333:14-24, (2015).

Mundy, W., T. Freudenrich, K. Wallace, AND M. Behl. EFFECT OF ORGANOPHOSPHORUS FLAME RETARDANTS ON NEURONAL DEVELOPMENT IN VITRO. Presented at Society of Toxicology, March 10 - 14, 2013.

Harrill, J., B. Robinette, T. Freudenrich, AND W. Mundy. USE OF HIGH CONTENT IMAGE ANALYSES TO DETECT CHEMICAL-MEDIATED EFFECTS ON NEURITE SUB-POPULATIONS IN PRIMARY RAT CORTICAL NEURONS. NEUROTOXICOLOGY. Intox Press, Inc, Little Rock, AR, 34:61-73, (2013).

Culbreth, M., J. Harrill, T. M. FREUDENRICH, W. R. MUNDY, AND TIM SHAFER. Comparison of Chemical-induced Changes in Proliferation and Apoptosis in Human and Mouse Neuroprogenitor Cells.***. NEUROTOXICOLOGY. Intox Press, Inc, Little Rock, AR, 33(6):1499-1510, (2012).

Culbreth, M., T. M. FREUDENRICH, TIM SHAFER, AND W. R. MUNDY. PROLIFERATION AS A KEY EVENT IN DEVELOPMENTAL TOXICITY: "CHEMICAL SCREENING IN HUMAN NEURAL STEM CELLS USING HIGH CONTENT IMAGING. Presented at Society of Toxicology (SOT) Annual Meeting, San Francisco, CA, March 11 - 15, 2012.

HARRILL, J., T. M. FREUDENRICH, B. ROBINETTE, AND W. R. MUNDY. Comparative sensitivity of human and rat neural cultures to chemical-induced inhibition of neurite outgrowth. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, 256(3):268-280, (2011).

Harrill, J., B. ROBINETTE, T. M. FREUDENRICH, AND W. R. MUNDY. IN VITRO SCREENING OF DEVELOPMENTAL NEUROTOXICANTS IN RAT PRIMARY CORTICAL NEURONS USING HIGH CONTENT IMAGE. Presented at 27th International Neurotoxicology Conference, Apex, NC, November 01 - 02, 2011.

RADIO, N., T. M. FREUDENRICH, B. ROBINETTE, K. M. CROFTON, AND W. R. MUNDY. Comparison of PC12 and Cerebellar Granule Cell Cultures for Evaluating Neurite Outgrowth Using High Content Screening. NEUROTOXICOLOGY AND TERATOLOGY. Elsevier Science Ltd, New York, NY, 32(1):25-35, (2010).

MUNDY, W. R., N. RADIO, AND T. M. FREUDENRICH. Neuronal models for evaluation of proliferation in vitro using high content screening. TOXICOLOGY. Elsevier Science Ltd, New York, NY, 270(2-3):121-130, (2010).

HARRILL, J., T. M. FREUDENRICH, D. Machacek, S. Stice, AND W. R. MUNDY. Quantitative assessment of neurite outgrowth in human embryonic stem cell derived hN2 cells using automated high-content image analysis. NEUROTOXICOLOGY. Intox Press, Inc, Little Rock, AR, 31(3):277-290, (2010).