Science Inventory

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Medlock Kakaley, E., N. Evans, M. Cardon, E. Green, J. Conley, L. Gray, P. Bradley, K. Smalling, AND K. Romanok. Effects-based tools to support consumers in tapwater use decisions: A multi-case study summary. National Water Quality Monitoring Council Meeting, Virginia Beach, VA, April 24 - 28, 2023.

Degitz, S., J. Olker, J. Denny, P. Degoey, P. Hartig, M. Cardon, S. Eytcheson, Jonathan Haselman, S. Mayasich, AND M. Hornung. In vitro screening of per- and polyfluorinated substances (PFAS) for interference with seven thyroid hormone system targets across nine assays. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 95:105762, (2024). https://doi.org/10.1016/j.tiv.2023.105762

Bradley, P., D. Kolpin, D. Thompson, K. Romanok, K. Smalling, S. Breitmeyer, D. Cwiertny, N. Evans, R. Field, M. Focazio, L. Freeman, C. Givens, J. Gray, G. Hager, M. Hladik, J. Hofmann, R. Jones, L. Kanagy, R. Lane, R. McCleskey, D. Medgyesi, E. Medlock Kakaley, S. Meppelink, M. Meyer, D. Stavreva, M. Ward, AND M. Cardon. Juxtaposition of Intense Agriculture, Vulnerable Aquifers, and Mixed Chemical/Microbial Exposures in Private-Well Tapwater in Northeast Iowa. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, Netherlands, 868:161672, (2023). https://doi.org/10.1016/j.scitotenv.2023.161672

Green, E., M. Cardon, N. Evans, AND E. MedlockKakaley. Application of the Generalized Concentration Addition Model to Predict In Vitro Responses of Tertiary Mixtures of Glucocorticoid Ligands@. Society of Toxicology, San Diego, California, March 27 - 31, 2022.

Evans, N., J. Conley, M. Cardon, P. Hartig, E. Medlock Kakaley, AND L. Gray. In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, 449:116136, (2022). https://doi.org/10.1016/j.taap.2022.116136

Bradley, P., E. Medlock Kakaley, K. Romanok, K. Smalling, M. Focazio, R. Charboneau, C. George, A. Navas-Acien, M. O'Leary, R. Red Cloud, T. Zacher, S. Breitmeyer, M. Cardon, C. Cuny, G. Ducheneaux, K. Enright, N. Evans, J. Gray, D. Harvey, M. Hladik, K. Loftin, R. McClesky, S. Meppelink, J. Valder, C. Weiss, AND L. White. Tapwater Exposures, Effects Potential, and Residential Risk Management in Northern Plains Nations. ACS ES&T Water. American Chemical Society, Washington, DC, 2(10):1772-1788, (2022). https://doi.org/10.1021/acsestwater.2c00293

Conley, J., C. Lambright, N. Evans, M. Cardon, E. MedlockKakaley, V. Wilson, AND E. Gray. A mixture of 15 phthalates and pesticides below individual chemical No Observed Adverse Effect Levels (NOAELs) produces reproductive tract malformations in the male rat. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, Netherlands, 156(106615):1, (2021). https://doi.org/10.1016/J.ENVINT.2021.106615

Green, E., E. MedlockKakaley, M. Cardon, AND N. Evans. Application of the Generalized Concentration Addition Model to Predict In Vitro Responses of Tertiary Mixtures of Glucocorticoid Ligands-extended abstract for SOT award. Society of Toxicology, Durham, North Carolina, March 12 - 26, 2021.

MedlockKakaley, E., M. Cardon, N. Evans, C. Lambright, B. Blackwell, R. Hofer, L. Hubbard, P. Bradley, J. Conley, E. Gray, AND D. Kolpin. Biological Activity in US Food Processing Plant Effluent. SETAC Europe Annual Meeting (Virtual), Durham-Virtual, NC, May 03 - 06, 2021.

Olker, J., J. Korte, J. Denny, J. Haselman, Philip Hartig, M. Cardon, M. Hornung, AND S. Degitz. In Vitro Screening for Chemical Inhibition of the Iodide Recycling Enzyme, Iodotyrosine Deiodinase. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 71:105073, (2021). https://doi.org/10.1016/j.tiv.2020.105073

Medlock Kakaley, E., M. Cardon, N. Evans, L. Iwanowicz, J. Allen, E. Wagner, H. Hur, K. Bokenkamp, S. Richardson, M. Plewa, P. Bradley, K. Romanok, D. Kolpin, J. Conley, E. Gray, Philip Hartig, AND V. Wilson. In vitro effects-based method and water quality screening model for use in pre- and post-distribution treated waters. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, Netherlands, 768:144750, (2021). https://doi.org/10.1016/j.scitotenv.2020.144750

Bradley, P., I. Padilla, K. Romanok, K. Smalling, M. Focazio, S. Breitmeyer, M. Cardon, J. Conley, N. Evans, C. Givens, J. Gray, L. Gray, P. Hartig, C. Higgins, M. Hladik, L. Iwanowicz, R. Lane, K. Loftin, R. McCleskey, C. McDonough, E. Medlock Kakaley, S. Meppelink, AND C. Weis. Pilot-scale expanded assessment of inorganic and organic tapwater exposures and predicted effects in Puerto Rico, USA. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, Netherlands, 788(147721):1, (2021). https://doi.org/10.1016/j.scitotenv.2021.147721

Bradley, P., D. LeBlanc, K. Romanok, M. Focazio, M. Cardon, J. Clark, J. Conley, N. Evans, C. Givens, J. Gray, E. Gray, Philip Hartig, C. Higgins, M. Hladik, K. Loftin, R. McClesky, C. McDonough, E. MedlockKakaley, C. Weis, V. Wilson, L. Iwanowicz, AND K. Smalling. Public and Private Tapwater: Comparative Analysis of Contaminant Exposure and Potential Risk, Cape Cod, MA, USA. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, Netherlands, 152(106487):1, (2021). https://doi.org/10.1016/j.envint.2021.106487

Medlock Kakaley, E., B. Blackwell, M. Cardon, J. Conley, N. Evans, D. Feifarek, E. Furlong, S. Glassmeyer, L. Gray, P. Hartig, D. Kolpin, M. Mills, L. Rosenblum, D. Villeneuve, AND V. Wilson. De Facto Water Reuse: Bioassay suite approach delivers depth and breadth in endocrine active compound detection. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, Netherlands, 699(134297):1, (2020). https://doi.org/10.1016/j.scitotenv.2019.134297

Gray, L., C. Lambright, N. Evans, M. Cardon, E. Medlock Kakaley, V. Wilson, AND J. Conley. Development of and AOP network for the developmental effects of exposure to PFAS. Virtual -Society of Toxicology Annual Meeting 2020, Anaheim, CA, March 15 - 20, 2020.

Lambright, C., N. Evans, M. Cardon, E. Medlock Kakaley, V. Wilson, J. Conley, AND L. Gray. Gene expression changes in maternal, fetal, and neonatal tissues from exposure to hexafluoropropylene oxide-dimer acid (HFPO-DA, GenX). Society of Toxicology Annual Meeting-Virtual -Webinar, Anaheim, CA, April 30, 2020.

Evans, N., M. Cardon, P. Hartig, E. Medlock Kakaley, V. Wilson, J. Conley, AND L. Gray. In vitro binding of human and rat PPAR alpha, beta/delta, and gamma receptors to PFAS, fatty acids, and clofibric acid. VIRTUAL-Society of Toxicology Annual Meeting, Anaheim, CA, April 30, 2020.

Gray, L., J. Furr, C. Lambright, N. Evans, P. Hartig, M. Cardon, V. Wilson, A. Hotchkiss, AND J. Conley. Quantification of uncertainties in extrapolating from in vitro androgen receptor (AR) antagonism to in vivo Hershberger Assay endpoints and adverse reproductive development in male rats. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 176(2):297-311, (2020). https://doi.org/10.1093/toxsci/kfaa067

Gray, E., J. Furr, J. Conley, C. Lambright, N. Evans, M. Cardon, V. Wilson, P. Foster, AND P. Hartig. A Conflicted Tale of Two Novel AR Antagonists In vitro and In vivo: Pyrifluquinazon versus Bisphenol C. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, , 632-643, (2019). https://doi.org/10.1093/toxsci/kfz010

Conley, J., C. Lambright, N. Evans, M. Strynar, J. McCord, B. McIntyre, G. Tavlos, M. Cardon, E. Medlock Kakaley, P. Hartig, V. Wilson, AND L. Gray. Adverse effects of oral gestational exposure to hexafluoropropylene oxide dimer acid (GenX) in the Sprague-Dawley rat- Presentation. Society of Toxicology, Baltimore, MD, March 10 - 14, 2019.

Conley, J., C. Lambright, N. Evans, M. Strynar, J. McCord, B. McIntyre, G. Travlos, M. Cardon, E. MedlockKakaley, P. Hartig, V. Wilson, AND E. Gray. Adverse maternal, fetal, and postnatal effects of Hexafluoropropylene oxide dimer acid (GenX) from oral gestational exposure in Sprague Dawley rats. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, , 1-13, (2019). https://doi.org/10.1289/EHP4372

MedlockKakaley, E., M. Cardon, E. Gray, P. Hartig, AND V. Wilson. Generalized concentration addition model predicts glucocorticoid activity bioassay responses to environmentally detected receptor-ligand mixtures. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, , 252-263, (2019). https://doi.org/10.1093/toxsci/kfy290

Olker, J., Joe Korte, J. Denny, P. Hartig, M. Cardon, J. O'Flanagan, M. Hornung, AND S. Degitz. In vitro screening assays for chemical inhibition of mammalian and amphibian iodotyrosine deiodinase. Society of Toxicology, Baltimore, MD, March 10 - 14, 2019.

MedlockKakaley, E., M. Cardon, J. Conley, N. Evans, E. Gray, P. Hartig, C. Lambright, AND V. Wilson. In vitro water quality screening tools for quantifying human and ecological-related endocrine activity. National Water Quality Monitoring Council Meeting, Denver, Colorado, March 25 - 29, 2019.

Olker, J., Jonathan Haselman, J. Korte, J. Denny, P. Hartig, M. Cardon, J. O'Flanagan, P. Degoey, M. Hornung, AND S. Degitz. Screening for chemical inhibition of the iodide recycling enzyme, a novel molecular target for thyroid axis disruption. SETAC North America, Toronto, ON, CANADA, November 03 - 07, 2019.