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Records 1 to 25 of 60 records from author Patrick Fitzsimmons

2023

Nichols, J., P. Fitzsimmons, A. Hoffman, AND K. Wong. In vitro-in vivo extrapolation of hepatic biotransformation data for fish. III. An in-depth case study with pyrene. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 42(7):1501-1515, (2023). https://doi.org/10.1002/etc.5626

2021

Nichols, J., A. Hoffman, J. Swintek, S. Droge, AND P. Fitzsimmons. Addition of phenylmethylsulfonyl fluoride (PMSF) substantially increases the working lifetime of the trout liver S9 substrate depletion assay resulting in improved detection of low intrinsic clearance rates. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 40(1):148-161, (2021). https://doi.org/10.1002/etc.4901

Droge, S., J. Armitage, J. Arnot, P. Fitzsimmons, AND J. Nichols. Biotransformation Potential of Cationic Surfactants in Fish Assessed with Rainbow Trout Liver S9 Fractions. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 40(11):3123-3136, (2021). https://doi.org/10.1002/etc.5189

2020

Saunders, L., P. Fitzsimmons, J. Nichols, AND F. Gobas. In vitro-in vivo extrapolation of hepatic and gastrointestinal biotrasnformation rates of hydrophobic chemicals in rainbow trout. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 228:1-12, (2020). https://doi.org/10.1016/j.aquatox.2020.105629

2019

Nichols, J., M. Ladd, A. Hoffman, AND P. Fitzsimmons. Biotransformation of pollycyclic aromatic hydrocarbons by trout liver S9 fractions: Evaluation of competitive inhibition using a substrate depletion approach. Fish Biotransformation in Bioaccumulation: Technical Workshop, sponsored by HESI, Washington, D.C, October 01 - 03, 2019.

Nichols, J., M. Ladd, A. Hoffman, AND P. Fitzsimmons. Biotransformation of polycyclic aromatic hydrocarbons by trout liver S9 fractions: Evaluation of competitive inhibition using a substrate depletion approach. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 38(12):2729-2739, (2019). https://doi.org/10.1002/etc.4595

2018

Fitzsimmons, P., A. Hoffman, K. Fay, AND J. Nichols. Allometric scaling of hepatic biotransformation in rainbow trout. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY - PART C: TOXICOLOGY & PHARMACOLOGY . Elsevier Science Ltd, New York, NY, 214:52-60, (2018). https://doi.org/10.1016/j.cbpc.2018.08.004

Nichols, J., M. Ladd, AND P. Fitzsimmons. Measurement of kinetic parameters for biotransformation of polycyclic aromatic hydrocarbons by trout liver S9 fractions: Implications for bioaccumulation assessment. Applied In Vitro Toxicology. Mary Ann Liebert, Inc., Larchmont, NY, 4(4):365-378, (2018). https://doi.org/10.1089/aivt.2017.0005

Saunders, L., A. Hoffman, P. Fitzsimmons, J. Nichols, AND F. Gobas. Quantitative in vitro - in vivo extrapolation of biotransformation rates for bioaccumulation assessment: Focus on organic sunscreen agents in trout. SETAC North America, Sacramento, CA, November 04 - 08, 2018.

Frew, J., J. Brown, P. Fitzsimmons, A. Hoffman, M. Sadilek, C. Grue, AND J. Nichols. Toxicokinetics of the neonicotinoid insecticide imidacloprid in rainbow trout (Oncorhynchus mykiss). COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY - PART C: TOXICOLOGY & PHARMACOLOGY . Elsevier Science Ltd, New York, NY, 205:34-42, (2018).

2017

Fitzsimmons, P., A. Hoffman, K. Fay, AND J. Nichols. Allometric scaling of hepatic biotransformation in rainbow trout. SETAC North America, Minneapolis, MN, November 12 - 16, 2017.

Fay, K., P. Fitzsimmons, A. Hoffman, AND J. Nichols. Comparison of trout hepatocytes and liver S9 fractions as in vitro models for predicting hepatic clearance in fish. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 36(2):463-471, (2017).

2016

Fay, K., P. Fitzsimmons, A. Hoffman, AND J. Nichols. Comparison of trout hepatocytes and liver S9 fractions as in vitro models for predicting hepatic clearance in fish. setac north america, Orlando, FL, November 06 - 10, 2016.

Ladd, M., P. Fitzsimmons, AND J. Nichols. Optimization of a UDP-glucuronosyltransferase assay for trout liver S9 fractions: Activity enhancement by alamethicin, a pore-forming peptide. XENOBIOTICA. Taylor & Francis, Inc., Philadelphia, PA, 46(12):1066-1075, (2016).

Consoer, D., A. Hoffman, P. Fitzsimmons, Pat Kosian, AND J. Nichols. Toxicokinetics of perfluorooctane sulfonate in rainbow trout (Oncorhynchus mykiss). ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 35(3):717-727, (2016).

2014

Connors, K., B. Du, P. Fitzsimmons, K. Chambliss, J. Nichols, AND B. Brooks. Method optimization for fathead minnow (Pimephales promelas) liver S9 isolation. SETAC North America, Vancouver, BC, CANADA, November 09 - 13, 2014.

Fay, K., P. Fitzsimmons, A. Hoffman, AND J. Nichols. Optimizing the use of rainbow trout hepatocytes for bioaccumulation assessments with fish. XENOBIOTICA. Taylor & Francis, Inc., Philadelphia, PA, 44(4):345-351, (2014).

Consoer, D., A. Hoffman, P. Fitzsimmons, Pat Kosian, AND J. Nichols. Toxicokinetics of perfluorooctanoate (PFOA) in rainbow trout(Oncorhynchus mykiss). AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 156:65-73, (2014).

2013

Connors, K., B. Du, P. Fitzsimmons, A. Hoffman, C. Chambliss, J. Nichols, AND B. Brooks. Comparative pharmaceutical metabolism by rainbow trout (Oncorhynchus mykiss) liver S9 fractions. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 32(8):1810-1818, (2013).

Nichols, J., A. Hoffman, T. Ter Laak, AND P. Fitzsimmons. Hepatic clearance of 6 polyaromatic aromatic hydrocarbons by isolated trout livers: Prediction from in vitro clearance by liver S9 fractions. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 136(2):359-372, (2013).

Fitzsimmons, P., A. Hoffman, AND J. Nichols. Incremental improvements to the trout S9 biotransformation assay. Presented at SETAC, Nashville, TN, November 17 - 21, 2013.

Nichols, J., D. Huggett, J. Arnot, P. Fitzsimmons, AND C. Cowan-Ellsberry. Towards improved models for predicting bioconcentration of well-metabolized compounds by rainbow trout using measured rates of in vitro intrinsic clearance. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 32(7):1611-1622, (2013).

Fay, K., P. Fitzsimmons, A. Hoffman, AND J. Nichols. Use of isolated hepatocytes to predict measured hepatic clearance of five polyaromatic hydrocarbons by perfused trout livers. Presented at Society of Toxicology, March 10 - 14, 2013.

2012

Nichols, J., A. Hoffman, P. Fitzsimmons, K. Fay, AND T. Ter Laak. Predicting the accumulation of well-metabolized chemicals by fish from measured rates of in vitro intrinsic clearance: Progress made and challenges ahead. Presented at Invited oral presentation, Stockholm University.

Fay, K., P. Fitzsimmons, A. Hoffman, AND J. Nichols. Use of isolated hepatocytes to predict measured hepatic clearance of five polyaromatic hydrocarbons by perfused trout livers, invited presentation. Presented at Toxicology Graduate Student Seminar, October 03, 2012.