Science Inventory

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Crofton, K., A. Bassan, M. Behl, Y. Chusak, E. Fritsche, J. Gearhart, M. Marty, M. Mumtaz, M. Pavan, P. Ruiz, T. Shafer, M. Sachana, R. Selvam, L. Stavitskaya, D. Szabo, S. Szabo, R. Tice, D. Wilson, D. Woolley, AND G. Myatt. Current status and future directions for a neurotoxicity hazard assessment framework that integrates in silico approaches. Computational Toxicology. Elsevier B.V., Amsterdam, Netherlands, 22:100223, (2022). https://doi.org/10.1016/j.comtox.2022.100223

Crofton, K. AND Mary E. Gilbert. NAFTA Developmental Neurotoxicity Guidance Document: Case Study – Chemical X. European Food safety Association (EFSA)-Virtual, RTP, Virtual, ITALY, April 26, 2021.

Medvedev, A., L. Medvedeva, E. Martsen, M. Moeser, K. Gorman, B. Lin, B. Blackwell, Dan Villeneuve, K. Houck, K. Crofton, AND S. Makarov. Harmonized Cross-Species Assessment of Endocrine and Metabolic Disruptors by Ecotox FACTORIAL Assay. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 54(19):12142-12153, (2020). https://doi.org/10.1021/acs.est.0c03375

Noyes, Pamela, K. Friedman, P. Browne, Jonathan Haselman, M. Gilbert, M. Hornung, Stanley Barone, K. Crofton, S. Laws, T. Stoker, S. Simmons, J. Tietge, AND S. Degitz. Evaluating chemicals for thyroid disruption: opportunities and challenges with in vitro testing and adverse outcome pathway approaches. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 127(9):095001, (2019). https://doi.org/10.1289/EHP5297

Paul-Friedman, K., M. Martin, K. Crofton, C. Hsu, S. Sakamuru, J. Zhao, M. Xia, R. Huang, D. Stevreva, V. Soni, L. Varticovski, R. Raziuddin, G. Hager, AND K. Houck. Limited chemical structural diversity found to modulate thyroid hormone receptor in the Tox21 chemical library. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 127(9):1-16, (2019). https://doi.org/10.1289/EHP5314

Deisenroth, C., J. Harrill, C. Brinkman, M. Xia, K. Crofton, AND R. Thomas. Development of a Human 3D Prostate Microtissue Assay for Anti-androgen Screening. Presented at SOT Annual Meeting 2018, San Antonio, TX, March 11 - 15, 2018.

Sachana, M., A. Bal-Price, K. Crofton, S. Bennekou, Tim Shafer, M. Behl, AND A. Terron. International regulatory and scientific effort for improved developmental neurotoxicity testing. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 167(1):45-57, (2019). https://doi.org/10.1093/toxsci/kfy211

Houck, K., A. Bone, K. Paul-Friedman, C. Hsu, S. Sakamuru, M. Xia, R. Huang, V. Soni, D. Stavreva, AND K. Crofton. Screening the 10K Tox21 chemical library for thyroid hormone receptor modulators. Society of Toxicology, San Antonio, TX, March 11 - 15, 2018.

Johnstone, A., J. Strickland, K. Crofton, C. Gennings, AND Tim Shafer. Effects of an Environmentally-relevant Mixture of Pyrethroid Insecticides on Spontaneous Activity in Primary Cortical Networks on Microelectrode Arrays. NEUROTOXICOLOGY. Elsevier B.V., Amsterdam, Netherlands, 60(16):234-239, (2017).

Juberg, D., T. Knudsen, M. Sander, N. Beck, E. Faustman, D. Mendrick, J. Fowle, T. Hartung, R. Tice, E. Lamazurier, R. Becker, S. Fitzpatrick, G. Daston, A. Harill, R. Hines, D. Keller, J. Lipscomb, D. Watson, T. Bahadori, AND K. Crofton. FutureTox III: Bridges for Translation. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 155(1):22-31, (2017).

Baker, N., T. Knudsen, K. Crofton, AND G. Patlewicz. High-throughput literature mining to support read-across predictions of toxicity. In Proceedings, American Society for Cellular and Computational Toxicology, Durham, NC, September 29 - 30, 2016. Society ALTEX Edition, Kuesnacht, Switzerland, 1, (2017).

Harrill, J., M. Martin, K. Houck, R. Judson, K. Crofton, AND R. Thomas. Optimization Of A High-Throughput Transcriptomic (HTTr) Bioactivity Screen In MCF7 Cells Using Targeted RNA-Seq (SOT). Presented at SOT annual meeting, Baltimore, MD, March 12 - 16, 2017. https://doi.org/10.23645/epacomptox.5176789

Paul-Friedman, K., J. Zhao, R. Huang, M. Xia, K. Crofton, AND K. Houck. Screening the Tox21 10K library for thyroid stimulating hormone receptor agonist and antagonist activity (SOT annual meeting). Presented at SOT Annual Meeting, Baltimore, Maryland, March 12 - 16, 2017. https://doi.org/10.23645/epacomptox.5176897

Baker, N., T. Knudsen, A. Williams, K. Crofton, AND G. Patlewicz. Supporting read-across predictions of chemical toxicity using high-throughput text-mining (ACS 2017 Spring meeting ). Presented at ACS 2017 Spring National Meeting, San Francisco, CA, April 02 - 06, 2017. https://doi.org/10.23645/epacomptox.5057962

Baker, N., T. Knudsen, A. Williams, AND K. Crofton. Text-mining strategies to support computational research in chemical toxicity (ACS 2017 Spring meeting). Presented at ACS National Meeting, San Francisco, California, April 03 - 06, 2017. https://doi.org/10.23645/epacomptox.5058016

Crofton, K. Update on NCCT Transcriptomic and Metabolic Retrofit Projects. Endocrine Policy Forum, RTP,NC, October 10, 2017.

Patlewicz, G., N. Baker, T. Knudsen, AND K. Crofton. Using high-throughput literature mining to support read-across predictions of skin sensitization (WC). Presented at 10th World Congress on Alternatives and Animal Use in the Life Sciences, Seattle, WA, August 20 - 24, 2017.

Baker, N., T. Knudsen, K. Crofton, AND G. Patlewicz. Using high-throughput literature mining to support read-across predictions of toxicity (SOT). Presented at 2017 SOT National Meeting, Baltimore, Maryland, March 12 - 16, 2017. https://doi.org/10.23645/epacomptox.5178559

Gilbert, M., K. Crofton, K. Paul-Friedman, J. Haselman, S. Degitz, M. Hornung, D. Knapen, L. Vergauwen, E. Stinckens, S. Marty, R. Zoeller, AND B. Demeniex. A Network of AOPs for reduced thyroid hormone synthesis derived from inhibition of Thyroperoxidase - A common Molecular Initiating Event Leading to Species-Specific Indices of Adversity. U.S. EPA Office of Research and Development, Washington, DC, 2016.

Rosenberg, S., N. Nikolov, M. Dybdahl, Steve Simmons, K. Crofton, Eric Watt, K. Paul Friedman, R. Judson, AND E. Wedebye. A QSAR Model for Thyroperoxidase Inhibition and Screening of a Large Set of Environmental Chemicals (SOT). Presented at SOT Annual Meeting, New Orleans, LA, March 13 - 17, 2016. https://doi.org/10.23645/epacomptox.5155810

Crofton, K. Alternative Test Methods for Developmental Neurotoxicity: A History and Path Forward (OECD EFSA workshop). Presented at OECD EFSA DNT workshop, Brussels, BELGIUM, October 18 - 19, 2016. https://doi.org/10.23645/epacomptox.5056810

Judson, R., K. Houck, M. Martin, A. Richard, T. Knudsen, I. Shah, S. Little, J. Wambaugh, Woodrow Setzer, P. Kothiya, J. Phuong, D. Filer, D. Smith, D. Reif, D. Rotroff, N. Kleinstreuer, N. Sipes, M. Xia, R. Huang, K. Crofton, AND R. Thomas. Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 152(2):323-339, (2016).

Crofton, K. Computational Toxicology in EPA (CS SOT MEETING). Presented at Central States SOT Meeting, Iowa City, IA, November 18, 2016. https://doi.org/10.23645/epacomptox.5056798

Crofton, K. Current Applications and Future Directions for 21st Century Toxicity Testing and Risk Assessment (Washington, DC Modernized TSCA meeting). Presented at Opportunities and Challenges in Using Advanced 21st Century Toxicity Testing and Risk Assessment Methods in a Modernized TSCA, Washington, DC, February 08, 2016. https://doi.org/10.23645/epacomptox.5071234

Rosenberg, S., N. Nikolov, M. Dybdahl, Steve Simmons, K. Crofton, Eric Watt, K. Paul-Friedman, R. Judson, AND E. Wedebye. Development of a QSAR Model for Thyroperoxidase Inhbition and Screening of 72,524 REACH substances - (Eurotox 2016). Presented at EUROTOX 2016, Seville, SPAIN, September 04 - 07, 2016. https://doi.org/10.23645/epacomptox.5189476