Science Inventory

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Degitz, S., J. Olker, J. Denny, P. Degoey, P. Hartig, M. Cardon, S. Eytcheson, Jonathan Haselman, S. Mayasich, AND M. Hornung. In vitro screening of per- and polyfluorinated substances (PFAS) for interference with seven thyroid hormone system targets across nine assays. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 95:105762, (2024). https://doi.org/10.1016/j.tiv.2023.105762

Evans, N., J. Conley, M. Cardon, P. Hartig, E. Medlock Kakaley, AND L. Gray. In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, 449:116136, (2022). https://doi.org/10.1016/j.taap.2022.116136

Olker, J., J. Korte, J. Denny, J. Haselman, Philip Hartig, M. Cardon, M. Hornung, AND S. Degitz. In Vitro Screening for Chemical Inhibition of the Iodide Recycling Enzyme, Iodotyrosine Deiodinase. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 71:105073, (2021). https://doi.org/10.1016/j.tiv.2020.105073

Medlock Kakaley, E., M. Cardon, N. Evans, L. Iwanowicz, J. Allen, E. Wagner, H. Hur, K. Bokenkamp, S. Richardson, M. Plewa, P. Bradley, K. Romanok, D. Kolpin, J. Conley, E. Gray, Philip Hartig, AND V. Wilson. In vitro effects-based method and water quality screening model for use in pre- and post-distribution treated waters. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, Netherlands, 768:144750, (2021). https://doi.org/10.1016/j.scitotenv.2020.144750

Bradley, P., I. Padilla, K. Romanok, K. Smalling, M. Focazio, S. Breitmeyer, M. Cardon, J. Conley, N. Evans, C. Givens, J. Gray, L. Gray, P. Hartig, C. Higgins, M. Hladik, L. Iwanowicz, R. Lane, K. Loftin, R. McCleskey, C. McDonough, E. Medlock Kakaley, S. Meppelink, AND C. Weis. Pilot-scale expanded assessment of inorganic and organic tapwater exposures and predicted effects in Puerto Rico, USA. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, Netherlands, 788(147721):1, (2021). https://doi.org/10.1016/j.scitotenv.2021.147721

Bradley, P., D. LeBlanc, K. Romanok, M. Focazio, M. Cardon, J. Clark, J. Conley, N. Evans, C. Givens, J. Gray, E. Gray, Philip Hartig, C. Higgins, M. Hladik, K. Loftin, R. McClesky, C. McDonough, E. MedlockKakaley, C. Weis, V. Wilson, L. Iwanowicz, AND K. Smalling. Public and Private Tapwater: Comparative Analysis of Contaminant Exposure and Potential Risk, Cape Cod, MA, USA. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, Netherlands, 152(106487):1, (2021). https://doi.org/10.1016/j.envint.2021.106487

Mayasich, S., J. Korte, J. Denny, Philip Hartig, J. Olker, P. Degoey, J. O'Flanagan, S. Degitz, AND M. Hornung. Xenopus laevis and human type 3 iodothyronine deiodinase enzyme cross-species sensitivity to inhibition by ToxCast chemicals. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 73:105141, (2021). https://doi.org/10.1016/j.tiv.2021.105141

Medlock Kakaley, E., B. Blackwell, M. Cardon, J. Conley, N. Evans, D. Feifarek, E. Furlong, S. Glassmeyer, L. Gray, P. Hartig, D. Kolpin, M. Mills, L. Rosenblum, D. Villeneuve, AND V. Wilson. De Facto Water Reuse: Bioassay suite approach delivers depth and breadth in endocrine active compound detection. SCIENCE OF THE TOTAL ENVIRONMENT. Elsevier BV, AMSTERDAM, Netherlands, 699(134297):1, (2020). https://doi.org/10.1016/j.scitotenv.2019.134297

Evans, N., M. Cardon, P. Hartig, E. Medlock Kakaley, V. Wilson, J. Conley, AND L. Gray. In vitro binding of human and rat PPAR alpha, beta/delta, and gamma receptors to PFAS, fatty acids, and clofibric acid. VIRTUAL-Society of Toxicology Annual Meeting, Anaheim, CA, April 30, 2020.

Gray, L., J. Furr, C. Lambright, N. Evans, P. Hartig, M. Cardon, V. Wilson, A. Hotchkiss, AND J. Conley. Quantification of uncertainties in extrapolating from in vitro androgen receptor (AR) antagonism to in vivo Hershberger Assay endpoints and adverse reproductive development in male rats. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 176(2):297-311, (2020). https://doi.org/10.1093/toxsci/kfaa067

Gray, E., J. Furr, J. Conley, C. Lambright, N. Evans, M. Cardon, V. Wilson, P. Foster, AND P. Hartig. A Conflicted Tale of Two Novel AR Antagonists In vitro and In vivo: Pyrifluquinazon versus Bisphenol C. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, , 632-643, (2019). https://doi.org/10.1093/toxsci/kfz010

Conley, J., C. Lambright, N. Evans, M. Strynar, J. McCord, B. McIntyre, G. Tavlos, M. Cardon, E. Medlock Kakaley, P. Hartig, V. Wilson, AND L. Gray. Adverse effects of oral gestational exposure to hexafluoropropylene oxide dimer acid (GenX) in the Sprague-Dawley rat- Presentation. Society of Toxicology, Baltimore, MD, March 10 - 14, 2019.

Conley, J., C. Lambright, N. Evans, M. Strynar, J. McCord, B. McIntyre, G. Travlos, M. Cardon, E. MedlockKakaley, P. Hartig, V. Wilson, AND E. Gray. Adverse maternal, fetal, and postnatal effects of Hexafluoropropylene oxide dimer acid (GenX) from oral gestational exposure in Sprague Dawley rats. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, , 1-13, (2019). https://doi.org/10.1289/EHP4372

MedlockKakaley, E., M. Cardon, E. Gray, P. Hartig, AND V. Wilson. Generalized concentration addition model predicts glucocorticoid activity bioassay responses to environmentally detected receptor-ligand mixtures. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, , 252-263, (2019). https://doi.org/10.1093/toxsci/kfy290

Olker, J., Joe Korte, J. Denny, P. Hartig, M. Cardon, J. O'Flanagan, M. Hornung, AND S. Degitz. In vitro screening assays for chemical inhibition of mammalian and amphibian iodotyrosine deiodinase. Society of Toxicology, Baltimore, MD, March 10 - 14, 2019.

MedlockKakaley, E., M. Cardon, J. Conley, N. Evans, E. Gray, P. Hartig, C. Lambright, AND V. Wilson. In vitro water quality screening tools for quantifying human and ecological-related endocrine activity. National Water Quality Monitoring Council Meeting, Denver, Colorado, March 25 - 29, 2019.

Olker, J., Jonathan Haselman, J. Korte, J. Denny, P. Hartig, M. Cardon, J. O'Flanagan, P. Degoey, M. Hornung, AND S. Degitz. Screening for chemical inhibition of the iodide recycling enzyme, a novel molecular target for thyroid axis disruption. SETAC North America, Toronto, ON, CANADA, November 03 - 07, 2019.

Olker, J., Joe Korte, J. Denny, P. Hartig, M. Cardon, C. Knutsen, P. Kent, J. Christensen, S. Degitz, AND M. Hornung. Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 168(2):430-442, (2019). https://doi.org/10.1093/toxsci/kfy302

Conley, J., C. Lambright, N. Evans, M. Strynar, J. McCord, B. McIntyre, G. Travlos, M. Cardon, E. MedlockKakaley, P. Hartig, V. Wilson, AND E. Gray. Adverse effects of oral gestational exposure to hexafluoropropylene oxide dimer acid (GenX) in the Sprague-Dawley rat. Society of Environmental Toxicology and Chemistry, Sacramento, CA, November 04 - 08, 2018.

Evans, N., J. Conley, M. Cardon, P. Hartig, AND V. Wilson. Cumulative assessment of steroid receptor mediated activity of contaminants in water samples using in vitro bioassays. SOT, San Antonio, Texas, March 11 - 15, 2018.

Hartig, P., J. Conley, C. Lambright, N. Evans, M. Cardon, V. Wilson, M. Strynar, J. McCord, B. Mcintyre, G. Travlos, AND E. Gray. GenX (FRD-902, ammonium (2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate) Does Not Display Estrogenic, (anti)androgenic or Glucocorticoid-like Activity In Vitro Whereas In Utero Exposure Induces Dose-related Maternal And Fetal Rat Liver PPAR Pathway Gene Expression Without Affecting Fetal Testis Testosterone Production. SOT 2018 Annual Meeting, San Antonio, TX, March 11 - 15, 2018.

MedlockKakaley, E., M. Cardon, J. Conley, N. Evans, E. Gray, P. Hartig, C. Lambright, AND V. Wilson. Generalized concentration addition mixtures model predicts glucocorticoid receptor activation by environmental full and partial agonist mixtures. Carolinas Society of Environmental oxicology and Chemistry, Research triangle Park, North Carolina, April 25 - 27, 2018.

MedlockKakaley, E., M. Cardon, E. Gray, P. Hartig, AND V. Wilson. Generalized concentration addition mixtures model predicts glucocorticoid receptor activation by environmental full and partial agonists. Society of Environmental Toxicology and Chemistry Annual Meeting, Sacramento, California, November 04 - 08, 2018.

Olker, J., Joe Korte, P. Hartig, M. Cardon, M. Hornung, AND S. Degitz. In Vitro screening for chemical inhibitors of human and amphibian iodotyrosine deiodinase activity. SETAC North America, Sacramento, CA, November 04 - 08, 2018.

Hornung, M., S. Degitz, J. Olker, Joe Korte, J. Denny, S. Laws, T. Stoker, P. Hartig, M. Cardon, D. Hallinger, A. Murr, A. Buckalew, J. Wang, K. Paul-Friedman, AND Steve Simmons. In vitro chemical screening assays to identify thyroid hormone disruptors. SETAC North America Focused Topic Meeting, Durham, NC, April 16 - 18, 2018.