Science Inventory

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Conley, J., S. Boyd, E. Hunter, AND T. Shafer. Development of a Functional Assay using Human Brain Organoids to Study Developmental Neurotoxicity. SOT Conference 2024: A New Approach Method (NAM) to Screen for the Impact of Endogenous Stress on Chemical Toxicity, Salt Lake City, UT, March 10 - 14, 2024. https://doi.org/10.23645/epacomptox.25488151

Park, S., D. Gallegos, S. Jeffay, E. Hunter, AND B. Chorley. All-Trans Retinoic Acid-Mediated Transcriptomic Signatures in Human Pluripotent Stem Cells at Single-Cell Resolution. Environmental Mutagenesis and Genomics Society (EMGS) 54th Annual Meeting, Chicago, IL, September 09 - 13, 2023. https://doi.org/10.23645/epacomptox.24128769

Conley, J., E. Hunter, AND T. Shafer. Human Brain Organoid Model to Study Developmental Neurotoxicity. North Carolina Society of Toxicology (NCSOT) Annual Meeting, RTP, NC, September 14, 2023. https://doi.org/10.23645/epacomptox.24157887

Hunter, E. AND S. Park. Microphysiological Models: Tools and Applications for Developmental Toxicology. Birth Defects Research and Prevention Annual Meeting, Vancouver, CANADA, June 25 - 29, 2022. https://doi.org/10.23645/epacomptox.20749144

Zurlinden, T., K. Saili, N. Rush, P. Kothiya, R. Judson, K. Houck, E. Hunter, N. Baker, J. Palmer, R. Thomas, AND T. Knudsen. Profiling the ToxCast Library With a Pluripotent Human (H9) Stem Cell Line-Based Biomarker Assay for Developmental Toxicity. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 174(2):189-209, (2020). https://doi.org/10.1093/toxsci/kfaa014

Knudsen, T. B., A. M. Richard, P. G. Kothiya, R. S. Judson, K. A. Houck, K. C. Crofton, R. S. Thomas, S. Little, E. S. Hunter, N. C. Baker, C. K. M. Leung, J. Palmer, A. Smith, M. Colwell, P. West, R. Burrier, AND L. Egnash. Evaluation of 1066 ToxCast Chemicals in a human stem cell assay for developmental toxicity (SOT). Presented at Society of Toxicology, San Diego, CA, March 21 - 26, 2015. https://doi.org/10.23645/epacomptox.5178703

Narotsky, M., G. Klinefelter, J. Goldman, D. Best, Anthony McDonald, L. Strader, J. Suarez, A. Murr, I. Thillainadarajah, E. Sidney Hunter, S. Richardson, T. Speth, R. Miltner, J. Pressman, L. Teuschler, G. Rice, V. C. Moser, R. Luebke, AND Jane Ellen Simmons. Comprehensive Assessment of a Chlorinated Drinking Water Concentrate in a Rat Multigenerational Reproductive Toxicity Study##. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 47(18):10653-59, (2013).

KNUDSEN, T. B., N. SIPES, N. KLEINSTREUER, M. ROUNTREE, N. C. BAKER, R. M. SPENCER, K. J. CHANDLER, S. J. PADILLA, T. TAL, AND E. S. HUNTER. Computational toxicology and in silico modeling of embryogenesis . Presented at 40th Meeting of the European Teratology Society, ETS-EUSAAT Symposium, Johannes Kepler University, Linz, AUSTRIA, September 02 - 05, 2012.

NAROTSKY, M. G., J. G. PRESSMAN, R. J. MILTNER, T. F. SPETH, L. K. TEUSCHLER, G. E. RICE, S. D. RICHARDSON, D. S. BEST, T. A. MCDONALD, E. S. HUNTER, AND J. E. SIMMONS. Developmental Toxicity Evaluations of Whole Mixtures of Disinfection By-products using Concentrated Drinking Water in Rats: Gestational and Lactational Effects of Sulfate and Sodium. BIRTH DEFECTS RESEARCH PART B: DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 95(3):202-212, (2012).

NAROTSKY, M. G., J. G. Pressman, R. J. Miltner, T. F. Speth, L. K. Teuschler, S. D. RICHARDSON, D. S. BEST, T. A. MCDONALD, E. S. HUNTER, AND J. E. SIMMONS. Developmental Toxicity Evaluations of Whole Mixtures of Disinfection By-products using Concentrated Drinking Water in Rats: Gestational and Lactational Effects of Sulfate and Sodium*. BIRTH DEFECTS RESEARCH PART B: DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 95(3):202-12, (2012).

BARRIER, M., K. J. CHANDLER, S. C. JEFFAY, M. R. HOOPES, T. B. KNUDSEN, AND E. S. HUNTER. Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity (ACDC) Assay: Book Chapter. 2012 Edition, Chapter 11, Craig Harris; Jason M. Hansen (ed.), Developmental Toxicology; Methods and Protocols; Series: Methods in Molecular Biology, Springer Protocols. Humana Press Incorporated, Totowa, NJ, 889:181-196, (2012).

BARRIER, M., K. J. CHANDLER, S. C. JEFFAY, M. Hoopes, T. Knudson, AND E. S. HUNTER. Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity (ACDC) assay-Book Chapter*. Chapter 11, J. Hansen & C. Harris (ed.), Developmental Toxicity: Series: Methods in Molecular Biology. Humana Press Incorporated, Totowa, NJ, 889:181-195, (2012).

CHANDLER, K. J., E. S. HUNTER, M. R. HOOPES, S. C. JEFFAY, H. P. NICHOLS, N. KLEINSTREUER, AND T. B. KNUDSEN. REDOX DISRUPTING POTENTIAL OF TOXCAST CHEMICALS RANKED BY ACTIVITY IN MOUSE EMBRYONIC STEM CELLS. Presented at The Society of Toxicology (SOT) 51st Annual Meeting and ToxExpo 2012, Moscone Convention Center, San Francisco, CA, March 11 - 15, 2012.

CHANDLER, K. J., E. S. HUNTER, M. L. HOOPES, S. C. JEFFAY, H. P. NICHOLS, N. KLEINSTREUER, AND T. Knudsen. Redox Disrupting Potential of ToxCast™Chemicals Ranked by Activity in Mouse Embryonic Stem Cells. Presented at Society of Toxicology (SOT) Annual Meeting, San Francisco, CA, March 11 - 15, 2012.

CHANDLER, K. J., E. S. HUNTER, S. C. JEFFAY, H. P. NICHOLS, N. KLEINSTREUER, N. SIPES, AND T. Knudson. A Redox Sensitive Pathway in the Mouse ES Cell Assay Modeled From ToxCast HTS Data. Presented at Society of Teratology Annual Meeting, San Diego, CA, June 25 - 29, 2011.

TEUSCHLER, L. K., L. S. Aume, G. E. RICE, J. E. SIMMONS, J. G. PRESSMAN, M. G. NAROTSKY, T. F. SPETH, R. J. MILTNER, E. S. HUNTER, A. McDonald, J. Craft, P. I. Feder, A. Fristachi, S. Parvez, AND S. D. Richardson. A Statistical Approach for Judging Stability of Whole Mixture Chemical Composition over Time for Highly Complex Disinfection By-Product Mixtures from EPA's Four Lab Study. Presented at Society for Risk Analysis 2011 Annual Meeting, Charleston, SC, December 04 - 07, 2011.

Nichols, H., M. BARRIER, S. C. JEFFAY, S. CHANDLER, S. SIMMONS, AND E. S. HUNTER. Assessment of a 42 metal salts chemical library in mouse embryonic stem cells. Presented at Teratology Society Annual Meeting, San Diego, CA, June 25 - 29, 2011.

Hoopes, M., N. Klleinstreuer, K. Chandler, T. Knudsen, AND E. S. HUNTER. Effects of 5HPP-33,an antiangiogenic thalidomide analog, in mouse whole embryo culture. Presented at Teratology Society Meeting, San Diego, CA, June 23 - 29, 2011.

Jeffay, S., M. Barrier, H. Nichols, K. Chandler, A. V. Singh, T. Chandler, T. Knudson, AND E. S. HUNTER. Effects of the EVCAM chemical validation library on differentiation using marker gene expression in lmouse embryonic stem cells. Presented at Teratology Society Annual meeting, San Diego, CA, June 25 - 29, 2011.

CHANDLER, K. J., M. BARRIER, S. C. JEFFAY, H. P. NICHOLS, N. KLEINSTREUER, A. Singh, D. REIF, N. SIPES, R. JUDSON, D. J. DIX, R. J. KAVLOCK, E. S. HUNTER, AND T. Knudsen. Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay. PLOS ONE . Public Library of Science, San Francisco, CA, 6(6):e1840, (2011).

CHANDLER, K. J., E. S. HUNTER, S. C. JEFFAY, H. P. NICHOLS, M. Hoopes, M. BARRIER, N. SIPES, N. KLEINSTREUER, A. Singh, AND T. Knudson. High-throughput Screening of ToxCast™ Phase I Chemicals in a Mouse Embryonic Stem Cell (mESC) Assay Reveals Disruption of Potential Toxicity Pathways. Presented at Society of Toxicology (SOT) annual meeting, Washington, DC, March 06 - 10, 2011.

BARRIER, M., S. C. JEFFAY, H. P. NICHOLS, K. J. CHANDLER, M. Hoopes, K. Slentz-Kesler, AND E. S. HUNTER. Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity (ACDC) assay. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 31(4):383-391, (2011).

NAROTSKY, M. G., D. S. BEST, A. Mc Donald, E. A. Godin, E. S. HUNTER, AND J. E. SIMMONS. Pregnancy loss and eye malformations in offspring of F344 rats following gestational exposure to mixtures of regulated trihalomethanes and haloacetic acids. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 31(1):59-65, (2011).

NAROTSKY, M. G., J. M. GOLDMAN, D. S. BEST, A. E. MURR, G. R. KLINEFELTER, L. F. STRADER, J. D. Saurez, J. G. PRESSMAN, R. J. MILTNER, T. F. SPETH, L. K. TEUSCHLER, G. E. RICE, S. D. RICHARDSON, T. A. MCDONALD, E. S. HUNTER, AND J. E. SIMMONS. Assessment of Reproductive and Developmental Toxicity of Mixtures of Regulated Drinking Water Chlorination By-Products in a Multigenerational Rat Bioassay. Presented at Teratology Society Annual meeting, Louisville, KY, June 26 - 30, 2010.

PRESSMAN, J. G., S. D. RICHARDSON, T. F. SPETH, R. J. MILTNER, M. G. NAROTSKY, E. S. HUNTER, G. E. RICE, L. K. TEUSCHLER, T. A. MCDONALD, Shahid Parvez, S. W. Krasner, H. S. Weinberg, A. B. McKague, C. J. PARRETT, N. Bodin, R. Chinn, C. T. Lee, AND J. E. SIMMONS. Concentration, Chlorination, and Chemical Analysis of Drinking Water for Disinfection Byproduct Mixtures Health Effects Research: U.S. EPA’s Four Lab Study. ENVIRONMENTAL SCIENCE AND TECHNOLOGY. American Chemical Society, Washington, DC, 44(19):7184-7192, (2010).